Patents by Inventor R. Stephen Brown

R. Stephen Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11498853
    Abstract: A method and system for reversibly converting water between an initial ionic strength and an increased ionic strength, using a switchable additive, is described. The disclosed method and system can be used, for example, in distillation-free removal of water from solvents, solutes, or solutions. Following extraction of a solute from a medium by dissolving it in water, the solute can then be isolated from the aqueous solution or “salted-out” by converting the water to a solution having an increased ionic strength. The solute then separates from the increased ionic strength solution as a separate phase. Once the solute is, for example, decanted off, the increased ionic strength aqueous solution can be converted back to water having its original ionic strength and reused. Switching from lower to higher ionic strength is readily achieved using low energy methods such as bubbling with CO2, CS2 or COS.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: November 15, 2022
    Inventors: Philip G. Jessop, Sean M. Mercer, R. Stephen Brown, Tobias Robert
  • Publication number: 20190315637
    Abstract: A method and system for reversibly converting water between an initial ionic strength and an increased ionic strength, using a switchable additive, is described. The disclosed method and system can be used, for example, in distillation-free removal of water from solvents, solutes, or solutions. Following extraction of a solute from a medium by dissolving it in water, the solute can then be isolated from the aqueous solution or “salted-out” by converting the water to a solution having an increased ionic strength. The solute then separates from the increased ionic strength solution as a separate phase. Once the solute is, for example, decanted off, the increased ionic strength aqueous solution can be converted back to water having its original ionic strength and reused. Switching from lower to higher ionic strength is readily achieved using low energy methods such as bubbling with CO2, CS2 or COS.
    Type: Application
    Filed: February 19, 2019
    Publication date: October 17, 2019
    Inventors: Philip G. Jessop, Sean M. Mercer, R. Stephen Brown, Tobias Robert
  • Patent number: 10377647
    Abstract: Methods and systems for use of switchable water, which is capable of reversibly switching between an initial ionic strength and an increased ionic strength, is described. The disclosed methods and systems can be used, for example, in distillation-free removal of water from solvents, solutes, or solutions, desalination, clay settling, viscosity switching, etc. Switching from lower to higher ionic strength is readily achieved using low energy methods such as bubbling with C02, CS2 or COS or treatment with Bronsted acids. Switching from higher to lower ionic strength is readily achieved using low energy methods such as bubbling with air, inert gas, heating, agitating, introducing a vacuum or partial vacuum, or any combination or thereof.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: August 13, 2019
    Assignees: Queen's University at Kingson, Greencentre Canada
    Inventors: Philip G. Jessop, Sean M. Mercer, Tobias Robert, R. Stephen Brown, Timothy James Clark, Brian Ernest Mariampillai, Rui Resendes, Dominik Wechsler
  • Patent number: 9097672
    Abstract: A system for detecting presence of an organism having an enzyme in a sample, comprising: a cartridge for containing the sample and a substrate such that the enzyme can react with the substrate to produce a biological molecule; a partitioning element mounted in a recess in a base of the cartridge, the partitioning element allowing partitioning of the biological molecule thereinto; a light source for irradiating the biological molecule partitioned into the partitioning element; and, a detector for detecting fluorescence of the biological molecule partitioned into the partitioning element, the detected fluorescence being indicative of presence of the organism in the sample; wherein the light source is in a raised cartridge mount of the system that mates with the recess in the base of the cartridge.
    Type: Grant
    Filed: June 17, 2011
    Date of Patent: August 4, 2015
    Assignees: QUEENS'S UNIVERSITY AT KINGSTON, PATHOGEN DETECTION SYSTEMS, INC.
    Inventors: R. Stephen Brown, Eric Marcotte, Doug Wilton, Peter Gallant, David Dolphin, Lee Underwood
  • Patent number: 9056703
    Abstract: A container, comprising: a body; and, a closure; wherein the closure has a lid hinged to a ring mounted on the body, the lid moveable from an open position to a closed position; wherein the lid has a tab hinged thereto for: inserting into and engaging a slot formed in the ring as the lid is moved to the closed position from the open position to thereby lock the lid in the closed position; or, receiving and engaging a pin head of a pin mounted on the ring in a hole formed in the tab to thereby hold the lid in the closed position, the pin configured to detach from the ring when the tab and lid are returned to the opened position.
    Type: Grant
    Filed: June 17, 2011
    Date of Patent: June 16, 2015
    Assignees: QUEEN'S UNIVERSITY AT KINGSTON, PATHOGEN DETECTION SYSTEMS, INC.
    Inventors: R. Stephen Brown, Eric Marcotte, Doug Wilton, Peter Gallant, David Robinson, Les Stokes, Peter Holdcroft, Matthew Miles, Simon Wilkinson, Lee Underwood
  • Publication number: 20140295403
    Abstract: This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples.
    Type: Application
    Filed: November 18, 2013
    Publication date: October 2, 2014
    Applicant: QUEEN'S UNIVERSITY AT KINGSTON
    Inventors: R. Stephen BROWN, Samir P. TABASH, Igor S. KOZIN, Eric J.P. MARCOTTE, Arthur N. LEY, Kevin R. HALL, Moe HUSSAIN, Peter V. HODSON, Sr., Parveen AKHTAR, Raymond J. BOWERS, Robin A. WYNNE-EDWARDS, John G. ST. MARSEILLE
  • Publication number: 20140076810
    Abstract: Methods and systems for use of switchable water, which is capable of reversibly switching between an initial ionic strength and an increased ionic strength, is described. The disclosed methods and systems can be used, for example, in distillation-free removal of water from solvents, solutes, or solutions, desalination, clay settling, viscosity switching, etc. Switching from lower to higher ionic strength is readily achieved using low energy methods such as bubbling with C02, CS2 or COS or treatment with Bronsted acids. Switching from higher to lower ionic strength is readily achieved using low energy methods such as bubbling with air, inert gas, heating, agitating, introducing a vacuum or partial vacuum, or any combination or thereof.
    Type: Application
    Filed: December 15, 2011
    Publication date: March 20, 2014
    Applicants: Greencentre Canaga, Queens's University
    Inventors: Philip G. Jessop, Sean M. Mercer, Tobias Robert, R. Stephen Brown, Timothy James Clark, Brian Ernest Mariampillai, Rui Resendes, Dominik Wechsler
  • Patent number: 8632966
    Abstract: This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: January 21, 2014
    Assignee: Queen's University at Kingston
    Inventors: R. Stephen Brown, Samir P. Tabash, Igor S. Kozin, Eric J. P. Marcotte, Arthur N. Ley, Kevin R. Hall, Moe Hussain, Peter V. Hodson, Raymond J. Bowers, Robin A. Wynne-Edwards, John G. St. Marseille
  • Publication number: 20130217040
    Abstract: A system for detecting presence of an organism having an enzyme in a sample, comprising: a cartridge for containing the sample and a substrate such that the enzyme can react with the substrate to produce a biological molecule; a partitioning element mounted in a recess in a base of the cartridge, the partitioning element allowing partitioning of the biological molecule thereinto; a light source for irradiating the biological molecule partitioned into the partitioning element; and, a detector for detecting fluorescence of the biological molecule partitioned into the partitioning element, the detected fluorescence being indicative of presence of the organism in the sample; wherein the light source is in a raised cartridge mount of the system that mates with the recess in the base of the cartridge.
    Type: Application
    Filed: June 17, 2011
    Publication date: August 22, 2013
    Applicants: QUEEN'S UNIVERSITY AT KINGSTON, PATHOGEN DETECTION SYSTEMS, INC.
    Inventors: R. Stephen Brown, Eric Marcotte, Doug Wilton, Peter Gallant, David Dolphin, Lee Underwood
  • Publication number: 20130177937
    Abstract: A container, comprising: a body; and, a closure; wherein the closure has a lid hinged to a ring mounted on the body, the lid moveable from an open position to a closed position; wherein the lid has a tab hinged thereto for: inserting into and engaging a slot formed in the ring as the lid is moved to the closed position from the open position to thereby lock the lid in the closed position; or, receiving and engaging a pin head of a pin mounted on the ring in a hole formed in the tab to thereby hold the lid in the closed position, the pin configured to detach from the ring when the tab and lid are returned to the opened position.
    Type: Application
    Filed: June 17, 2011
    Publication date: July 11, 2013
    Applicant: PATHOGEN DETECTION SYSTEMS, INC.
    Inventors: R. Stephen Brown, Eric Marcotte, Doug Wilton, Peter Gallant, David Robinson, Les Stokes, Peter Holdcroft, Matthew Miles, Simon Wilkinson, Lee Underwood
  • Publication number: 20130105377
    Abstract: A method and system for reversibly converting water between an initial ionic strength and an increased ionic strength, using a switchable additive, is described. The disclosed method and system can be used, for example, in distillation-free removal of water from solvents, solutes, or solutions. Following extraction of a solute from a medium by dissolving it in water, the solute can then be isolated from the aqueous solution or “salted-out” by converting the water to a solution having an increased ionic strength. The solute then separates from the increased ionic strength solution as a separate phase. Once the solute is, for example, decanted off, the increased ionic strength aqueous solution can be converted back to water having its original ionic strength and reused. Switching from lower to higher ionic strength is readily achieved using low energy methods such as bubbling with CO2, CS2 or COS.
    Type: Application
    Filed: February 10, 2011
    Publication date: May 2, 2013
    Applicant: Queen's University at Kingston
    Inventors: Philip G. Jessop, Sean M. Mercer, R. Stephen Brown, Tobias Robert
  • Patent number: 8377686
    Abstract: This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples.
    Type: Grant
    Filed: June 16, 2008
    Date of Patent: February 19, 2013
    Inventors: R. Stephen Brown, Samir P. Tabash, Igor S. Kozin, Eric J. P. Marcotte, Arthur N. Ley, Kevin R. Hall, Moe Hussain, Peter V. Hodson, Raymond J. Bowers, Robin A. Wynne-Edwards, John G. St. Marseille
  • Patent number: 7776611
    Abstract: The invention relates to a method for sensing the presence of at least one analyte in a medium, comprising disposing in the medium a functionalized composite material such that the at least one analyte is absorbed by the functionalized composite material, the functionalized composite material having at least one optical property that is modulated by absorption of the at least one analyte; and measuring modulation of the at least one optical property of the functionalized composite material; wherein modulation of the at least one optical property of the functionalized composite material is indicative of the presence of the analyte in the medium. The invention also relates to an optical sensor for sensing the presence of at least one analyte in a medium, and a functionalized composite material having at least one optical property that is modulated upon absorption of one or more analyte.
    Type: Grant
    Filed: December 8, 2006
    Date of Patent: August 17, 2010
    Assignee: Queen's University at Kingston
    Inventors: Cathleen M. Crudden, Hans-Peter Loock, Steven E. Dickson, Jenny Du, Larbi M. S. Benhabib, R. Stephen Brown
  • Publication number: 20090117600
    Abstract: This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples.
    Type: Application
    Filed: June 16, 2008
    Publication date: May 7, 2009
    Applicant: QUEEN'S UNIVERSITY AT KINGSTON
    Inventors: R. Stephen Brown, Samir P. Tabash, Igor S. Kozin, Eric J.P. Marcotte, Arthur N. Ley, Kevin R. Hall, Moe Hussain, Peter V. Hodson, Raymond J. Bowers, Robin A. Wynne-Edwards, Parveen Akhtar, John G. St. Marseille
  • Patent number: 7402426
    Abstract: This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples.
    Type: Grant
    Filed: September 22, 2003
    Date of Patent: July 22, 2008
    Assignee: Queen's University at Kingston
    Inventors: R. Stephen Brown, Samir P. Tabash, Igor S. Kozin, Eric J. P. Marcotte, Arthur N. Ley, Kevin R. Hall, Moe Hussain, Peter V. Hodson, Parveen Akhtar, Raymond J. Bowers, Robin A. Wynne-Edwards, John G. St. Marseille
  • Patent number: D645221
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: September 13, 2011
    Assignees: Queen's University, Pathogen Detection Systems, Inc.
    Inventors: R. Stephen Brown, Eric Marcotte, Michelle Douma, Michael Miron, Doug Wilton, Peter Gallant, David Dolphin, Lee Underwood, David (Geoffrey) Robinson, Les Stokes, Peter Holdcroft, Matthew Miles
  • Patent number: D645772
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: September 27, 2011
    Assignees: Queen's University, Pathogen Detection Systems, Inc.
    Inventors: R. Stephen Brown, Eric Marcotte, Doug Wilton, Peter Gallant, David Dolphin, Michael Miron, Lee Underwood, David (Geoffrey) Robinson, Les Stokes, Peter Holdcroft, Matthew Brown
  • Patent number: D656287
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: March 20, 2012
    Assignees: Queen's University, Pathogen Detection Systems, Inc.
    Inventors: R. Stephen Brown, Eric Marcotte, Michelle Douma, Michael Miron, Doug Wilton, Peter Gallant, David Dolphin, Lee Underwood, David (Geoffrey) Robinson, Les Stokes, Peter Holdcroft, Matthew Miles
  • Patent number: D661701
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: June 12, 2012
    Assignee: Pathogen Detection Systems, Inc.
    Inventors: R. Stephen Brown, Eric Marcotte, Doug Wilton, Peter Gallant, David Dolphin, Tom Radcliffe, Michael Miron, Lee Underwood, Les Stokes, Peter Holdcroft, Simon Wilkinson
  • Patent number: D670471
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: November 6, 2012
    Assignees: Queen's University, Pathogen Detection Systems, Inc.
    Inventors: R. Stephen Brown, Eric Marcotte, Michelle Douma, Doug Wilton, Michael Miron