Patents by Inventor R. Stephen Brown
R. Stephen Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11498853Abstract: A method and system for reversibly converting water between an initial ionic strength and an increased ionic strength, using a switchable additive, is described. The disclosed method and system can be used, for example, in distillation-free removal of water from solvents, solutes, or solutions. Following extraction of a solute from a medium by dissolving it in water, the solute can then be isolated from the aqueous solution or “salted-out” by converting the water to a solution having an increased ionic strength. The solute then separates from the increased ionic strength solution as a separate phase. Once the solute is, for example, decanted off, the increased ionic strength aqueous solution can be converted back to water having its original ionic strength and reused. Switching from lower to higher ionic strength is readily achieved using low energy methods such as bubbling with CO2, CS2 or COS.Type: GrantFiled: February 19, 2019Date of Patent: November 15, 2022Inventors: Philip G. Jessop, Sean M. Mercer, R. Stephen Brown, Tobias Robert
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Publication number: 20190315637Abstract: A method and system for reversibly converting water between an initial ionic strength and an increased ionic strength, using a switchable additive, is described. The disclosed method and system can be used, for example, in distillation-free removal of water from solvents, solutes, or solutions. Following extraction of a solute from a medium by dissolving it in water, the solute can then be isolated from the aqueous solution or “salted-out” by converting the water to a solution having an increased ionic strength. The solute then separates from the increased ionic strength solution as a separate phase. Once the solute is, for example, decanted off, the increased ionic strength aqueous solution can be converted back to water having its original ionic strength and reused. Switching from lower to higher ionic strength is readily achieved using low energy methods such as bubbling with CO2, CS2 or COS.Type: ApplicationFiled: February 19, 2019Publication date: October 17, 2019Inventors: Philip G. Jessop, Sean M. Mercer, R. Stephen Brown, Tobias Robert
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Patent number: 10377647Abstract: Methods and systems for use of switchable water, which is capable of reversibly switching between an initial ionic strength and an increased ionic strength, is described. The disclosed methods and systems can be used, for example, in distillation-free removal of water from solvents, solutes, or solutions, desalination, clay settling, viscosity switching, etc. Switching from lower to higher ionic strength is readily achieved using low energy methods such as bubbling with C02, CS2 or COS or treatment with Bronsted acids. Switching from higher to lower ionic strength is readily achieved using low energy methods such as bubbling with air, inert gas, heating, agitating, introducing a vacuum or partial vacuum, or any combination or thereof.Type: GrantFiled: December 15, 2011Date of Patent: August 13, 2019Assignees: Queen's University at Kingson, Greencentre CanadaInventors: Philip G. Jessop, Sean M. Mercer, Tobias Robert, R. Stephen Brown, Timothy James Clark, Brian Ernest Mariampillai, Rui Resendes, Dominik Wechsler
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Patent number: 9097672Abstract: A system for detecting presence of an organism having an enzyme in a sample, comprising: a cartridge for containing the sample and a substrate such that the enzyme can react with the substrate to produce a biological molecule; a partitioning element mounted in a recess in a base of the cartridge, the partitioning element allowing partitioning of the biological molecule thereinto; a light source for irradiating the biological molecule partitioned into the partitioning element; and, a detector for detecting fluorescence of the biological molecule partitioned into the partitioning element, the detected fluorescence being indicative of presence of the organism in the sample; wherein the light source is in a raised cartridge mount of the system that mates with the recess in the base of the cartridge.Type: GrantFiled: June 17, 2011Date of Patent: August 4, 2015Assignees: QUEENS'S UNIVERSITY AT KINGSTON, PATHOGEN DETECTION SYSTEMS, INC.Inventors: R. Stephen Brown, Eric Marcotte, Doug Wilton, Peter Gallant, David Dolphin, Lee Underwood
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Patent number: 9056703Abstract: A container, comprising: a body; and, a closure; wherein the closure has a lid hinged to a ring mounted on the body, the lid moveable from an open position to a closed position; wherein the lid has a tab hinged thereto for: inserting into and engaging a slot formed in the ring as the lid is moved to the closed position from the open position to thereby lock the lid in the closed position; or, receiving and engaging a pin head of a pin mounted on the ring in a hole formed in the tab to thereby hold the lid in the closed position, the pin configured to detach from the ring when the tab and lid are returned to the opened position.Type: GrantFiled: June 17, 2011Date of Patent: June 16, 2015Assignees: QUEEN'S UNIVERSITY AT KINGSTON, PATHOGEN DETECTION SYSTEMS, INC.Inventors: R. Stephen Brown, Eric Marcotte, Doug Wilton, Peter Gallant, David Robinson, Les Stokes, Peter Holdcroft, Matthew Miles, Simon Wilkinson, Lee Underwood
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Publication number: 20140295403Abstract: This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples.Type: ApplicationFiled: November 18, 2013Publication date: October 2, 2014Applicant: QUEEN'S UNIVERSITY AT KINGSTONInventors: R. Stephen BROWN, Samir P. TABASH, Igor S. KOZIN, Eric J.P. MARCOTTE, Arthur N. LEY, Kevin R. HALL, Moe HUSSAIN, Peter V. HODSON, Sr., Parveen AKHTAR, Raymond J. BOWERS, Robin A. WYNNE-EDWARDS, John G. ST. MARSEILLE
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Publication number: 20140076810Abstract: Methods and systems for use of switchable water, which is capable of reversibly switching between an initial ionic strength and an increased ionic strength, is described. The disclosed methods and systems can be used, for example, in distillation-free removal of water from solvents, solutes, or solutions, desalination, clay settling, viscosity switching, etc. Switching from lower to higher ionic strength is readily achieved using low energy methods such as bubbling with C02, CS2 or COS or treatment with Bronsted acids. Switching from higher to lower ionic strength is readily achieved using low energy methods such as bubbling with air, inert gas, heating, agitating, introducing a vacuum or partial vacuum, or any combination or thereof.Type: ApplicationFiled: December 15, 2011Publication date: March 20, 2014Applicants: Greencentre Canaga, Queens's UniversityInventors: Philip G. Jessop, Sean M. Mercer, Tobias Robert, R. Stephen Brown, Timothy James Clark, Brian Ernest Mariampillai, Rui Resendes, Dominik Wechsler
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Patent number: 8632966Abstract: This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples.Type: GrantFiled: January 10, 2013Date of Patent: January 21, 2014Assignee: Queen's University at KingstonInventors: R. Stephen Brown, Samir P. Tabash, Igor S. Kozin, Eric J. P. Marcotte, Arthur N. Ley, Kevin R. Hall, Moe Hussain, Peter V. Hodson, Raymond J. Bowers, Robin A. Wynne-Edwards, John G. St. Marseille
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Publication number: 20130217040Abstract: A system for detecting presence of an organism having an enzyme in a sample, comprising: a cartridge for containing the sample and a substrate such that the enzyme can react with the substrate to produce a biological molecule; a partitioning element mounted in a recess in a base of the cartridge, the partitioning element allowing partitioning of the biological molecule thereinto; a light source for irradiating the biological molecule partitioned into the partitioning element; and, a detector for detecting fluorescence of the biological molecule partitioned into the partitioning element, the detected fluorescence being indicative of presence of the organism in the sample; wherein the light source is in a raised cartridge mount of the system that mates with the recess in the base of the cartridge.Type: ApplicationFiled: June 17, 2011Publication date: August 22, 2013Applicants: QUEEN'S UNIVERSITY AT KINGSTON, PATHOGEN DETECTION SYSTEMS, INC.Inventors: R. Stephen Brown, Eric Marcotte, Doug Wilton, Peter Gallant, David Dolphin, Lee Underwood
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Publication number: 20130177937Abstract: A container, comprising: a body; and, a closure; wherein the closure has a lid hinged to a ring mounted on the body, the lid moveable from an open position to a closed position; wherein the lid has a tab hinged thereto for: inserting into and engaging a slot formed in the ring as the lid is moved to the closed position from the open position to thereby lock the lid in the closed position; or, receiving and engaging a pin head of a pin mounted on the ring in a hole formed in the tab to thereby hold the lid in the closed position, the pin configured to detach from the ring when the tab and lid are returned to the opened position.Type: ApplicationFiled: June 17, 2011Publication date: July 11, 2013Applicant: PATHOGEN DETECTION SYSTEMS, INC.Inventors: R. Stephen Brown, Eric Marcotte, Doug Wilton, Peter Gallant, David Robinson, Les Stokes, Peter Holdcroft, Matthew Miles, Simon Wilkinson, Lee Underwood
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Publication number: 20130105377Abstract: A method and system for reversibly converting water between an initial ionic strength and an increased ionic strength, using a switchable additive, is described. The disclosed method and system can be used, for example, in distillation-free removal of water from solvents, solutes, or solutions. Following extraction of a solute from a medium by dissolving it in water, the solute can then be isolated from the aqueous solution or “salted-out” by converting the water to a solution having an increased ionic strength. The solute then separates from the increased ionic strength solution as a separate phase. Once the solute is, for example, decanted off, the increased ionic strength aqueous solution can be converted back to water having its original ionic strength and reused. Switching from lower to higher ionic strength is readily achieved using low energy methods such as bubbling with CO2, CS2 or COS.Type: ApplicationFiled: February 10, 2011Publication date: May 2, 2013Applicant: Queen's University at KingstonInventors: Philip G. Jessop, Sean M. Mercer, R. Stephen Brown, Tobias Robert
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Patent number: 8377686Abstract: This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples.Type: GrantFiled: June 16, 2008Date of Patent: February 19, 2013Inventors: R. Stephen Brown, Samir P. Tabash, Igor S. Kozin, Eric J. P. Marcotte, Arthur N. Ley, Kevin R. Hall, Moe Hussain, Peter V. Hodson, Raymond J. Bowers, Robin A. Wynne-Edwards, John G. St. Marseille
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Patent number: 7776611Abstract: The invention relates to a method for sensing the presence of at least one analyte in a medium, comprising disposing in the medium a functionalized composite material such that the at least one analyte is absorbed by the functionalized composite material, the functionalized composite material having at least one optical property that is modulated by absorption of the at least one analyte; and measuring modulation of the at least one optical property of the functionalized composite material; wherein modulation of the at least one optical property of the functionalized composite material is indicative of the presence of the analyte in the medium. The invention also relates to an optical sensor for sensing the presence of at least one analyte in a medium, and a functionalized composite material having at least one optical property that is modulated upon absorption of one or more analyte.Type: GrantFiled: December 8, 2006Date of Patent: August 17, 2010Assignee: Queen's University at KingstonInventors: Cathleen M. Crudden, Hans-Peter Loock, Steven E. Dickson, Jenny Du, Larbi M. S. Benhabib, R. Stephen Brown
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Publication number: 20090117600Abstract: This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples.Type: ApplicationFiled: June 16, 2008Publication date: May 7, 2009Applicant: QUEEN'S UNIVERSITY AT KINGSTONInventors: R. Stephen Brown, Samir P. Tabash, Igor S. Kozin, Eric J.P. Marcotte, Arthur N. Ley, Kevin R. Hall, Moe Hussain, Peter V. Hodson, Raymond J. Bowers, Robin A. Wynne-Edwards, Parveen Akhtar, John G. St. Marseille
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Patent number: 7402426Abstract: This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples.Type: GrantFiled: September 22, 2003Date of Patent: July 22, 2008Assignee: Queen's University at KingstonInventors: R. Stephen Brown, Samir P. Tabash, Igor S. Kozin, Eric J. P. Marcotte, Arthur N. Ley, Kevin R. Hall, Moe Hussain, Peter V. Hodson, Parveen Akhtar, Raymond J. Bowers, Robin A. Wynne-Edwards, John G. St. Marseille
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Patent number: D645221Type: GrantFiled: June 18, 2010Date of Patent: September 13, 2011Assignees: Queen's University, Pathogen Detection Systems, Inc.Inventors: R. Stephen Brown, Eric Marcotte, Michelle Douma, Michael Miron, Doug Wilton, Peter Gallant, David Dolphin, Lee Underwood, David (Geoffrey) Robinson, Les Stokes, Peter Holdcroft, Matthew Miles
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Patent number: D645772Type: GrantFiled: June 18, 2010Date of Patent: September 27, 2011Assignees: Queen's University, Pathogen Detection Systems, Inc.Inventors: R. Stephen Brown, Eric Marcotte, Doug Wilton, Peter Gallant, David Dolphin, Michael Miron, Lee Underwood, David (Geoffrey) Robinson, Les Stokes, Peter Holdcroft, Matthew Brown
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Patent number: D656287Type: GrantFiled: June 18, 2010Date of Patent: March 20, 2012Assignees: Queen's University, Pathogen Detection Systems, Inc.Inventors: R. Stephen Brown, Eric Marcotte, Michelle Douma, Michael Miron, Doug Wilton, Peter Gallant, David Dolphin, Lee Underwood, David (Geoffrey) Robinson, Les Stokes, Peter Holdcroft, Matthew Miles
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Patent number: D661701Type: GrantFiled: June 18, 2010Date of Patent: June 12, 2012Assignee: Pathogen Detection Systems, Inc.Inventors: R. Stephen Brown, Eric Marcotte, Doug Wilton, Peter Gallant, David Dolphin, Tom Radcliffe, Michael Miron, Lee Underwood, Les Stokes, Peter Holdcroft, Simon Wilkinson
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Patent number: D670471Type: GrantFiled: June 18, 2010Date of Patent: November 6, 2012Assignees: Queen's University, Pathogen Detection Systems, Inc.Inventors: R. Stephen Brown, Eric Marcotte, Michelle Douma, Doug Wilton, Michael Miron