Abstract: GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein A, Q, R1, R2, R3a, R3b, R4, R5, R6 and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

Abstract: GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein A, Q, R1, R2, R3a, R3b, R4, R5, R6 and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

Abstract: An efficient receiver system (80) adapted for use with a pulsed radar system. The receiver system (80) includes a first circuit (82) for receiving a first signal and providing a second signal in response thereto. A second circuit (96) compares the second signal to a predetermined sequence (98) and provides a compare signal in response thereto. A third circuit (104) stores information pertaining to the second signal in response to the compare signal. A fourth circuit (92) generates receiver system instructions based on the stored information. In a specific embodiment, the second signal is a digital signal and the sequence is a digital sequence. The pulsed radar system includes a circuit for receiving and collecting data during a first dwell and for processing the data during a subsequent dwell. An inter-dwell time interval exists between the first dwell and the second dwell. The first, second, third, and/or fourth circuits (82, 96, 104, and/or 92) operate during the inter-dwell period.