Abstract: A system and method are for analyzing fluorescence of fluorophors in an eye using a non-negative matrix factorization (NMF) method. The NMF method may be initialized with Gaussian mixture model fits and may optionally be constrained to provide identical abundance images for data obtained in response to two or more excitation wavelengths.

Abstract: A system and method for in vivo detection and quantification of drusen present in the retina via administering an excitation signal to the retina of the eye and detecting an electromagnetic emissions spectrum from the retina in response to the excitation signal. The electromagnetic emissions spectrum may be used to identify a plurality of component emissions spectra, each component emissions spectrum corresponding to fluorescence from a component of the retina, one of the component emissions spectra corresponding to a target emissions spectrum.

Abstract: A system and method for in vivo detection and quantification of drusen present in the retina via administering an excitation signal to the retina of the eye and detecting an electromagnetic emissions spectrum from the retina in response to the excitation signal. The electromagnetic emissions spectrum may be used to identify a plurality of component emissions spectra, each component emissions spectrum corresponding to fluorescence from a component of the retina, one of the component emissions spectra corresponding to a target emissions spectrum.

Abstract: A system and method are for analyzing fluorescence of fluorophors in an eye using a non-negative matrix factorization (NMF) method. The NMF method may be initialized with Gaussian mixture model fits and may optionally be constrained to provide identical abundance images for data obtained in response to two or more excitation wavelengths.

Abstract: Exemplary embodiments of the present disclosure can provide a retinal camera. The exemplary camera can include a body, at least one optical sensor which is (i) provided on the body, and (ii) configured to receive light directly from a lens of an eye, and a processing arrangement configured to generate an image based on the light received directly from the lens of the eye.

Abstract: This invention provides a method of leveling an image of a non-uniform background. The method uses all or a portion of the image data from the original image and mathematical algorithms to construct a model image that reflects the non-uniform background of the original image and subtract the model image from the original image to generate an image with a more uniform background. This invention also provides computer software for performing the methods of the invention.