Abstract: In the present invention, a right leg drive RLD monitoring system is employed on a medical computing system/computer, such as an ECG, HEMO and/or EP monitoring, mapping and/or recording system, that includes a number of RLD circuits to be utilized for different procedures or monitoring states to be performed using the system. The RLD monitoring system operates to actively monitor and/or record the feedback voltage to the RLD isolated from the patient. Using the measured feedback voltage data, the RLD monitoring system can identify and determine if the RLD circuit in use is approaching saturation, has reached saturation and the duration the RLD circuit was in saturation. The RLD monitoring system can concurrently and/or subsequently select and/or provide selection information regarding an optimal RLD circuit to be utilized to most effectively perform the desired function of the RLD in the procedure being performed using the monitoring, mapping and/or recording system.

Abstract: A Josephson junction (JJ) device is disclosed that includes a first superconductor structure having a bottom superconductor arm portion and a second superconductor structure having a top superconductor arm portion disposed substantially orthogonal to the bottom superconductor arm portion and overlapping the bottom superconductor arm portion in a JJ operation region. The JJ device further includes a dielectric material layer acting as a tunnel barrier disposed between the bottom superconductor arm portion and the top superconductor arm portion in the JJ operation region to form an operating JJ.

Abstract: A system for resource targeted scheduling for a PON network.

Abstract: Described herein are non-natural olivetolic acid cyclases (OAC) variants capable of forming a 2,4-dihydroxy-6-alkylbenzoic acid from a 3,5,7-trioxoacyl-CoA or a 3,5,7-trioxocarboxylate substrate at a greater rate than a wild type or control OAC. The non-natural OAC (and OLS) can be expressed in an engineered cell having a pathway to form cannabinoids, which include CBGA, its analogs and derivatives. CBGA can be used for the preparation of cannabigerol (CBG), which can be used in therapeutic compositions.

Abstract: A Josephson junction (JJ) device is provided. The JJ device comprises an operating JJ, a first hydrogen-trapping JJ having a first end coupled to a first end of the operating JJ and a second end coupled to a first superconductor wire, and a second hydrogen-trapping JJ having a first end coupled to a second end of the operating JJ and a second end coupled to a second superconductor wire. The first hydrogen-trapping JJ and the second hydrogen-trapping JJ mitigates hydrogen diffusion into the operating JJ.

Abstract: Described herein are fusion proteins including methanol dehydrogenase (MeDH) and at least one other polypeptide such as 3-hexulose-6-phosphate dehydrogenase (HPS) or 6-phospho-3-hexuloisomerase (PHI), such as DHAS synthase or fructose-6-Phosphate aldolase or such as DHA synthase or DHA kinase. In a localized manner, the fusion protein can promote the conversion of methanol to formaldehyde and then to a ketose phosphate such as hexulose 6-phosphate or then to DHA and G3P. When expressed in cells, the fusion proteins can promote methanol uptake and rapid conversion to the ketose phosphate or to the DHA and D3P, which in turn can be used in a pathway for the production of a desired bioproduct. Beneficially, the rapid conversion to the ketose phosphate or to the DHA and G3P can avoid the undesirable accumulation of formaldehyde in the cell.

Abstract: Described herein are fusion proteins including methanol dehydrogenase (MeDH) and at least one other polypeptide such as 3-hexulose-6-phosphate dehydrogenase (HPS) or 6-phospho-3-hexuloisomerase (PHI), such as DHAS synthase or fructose-6-Phosphate aldolase or such as DHA synthase or DHA kinase. In a localized manner, the fusion protein can promote the conversion of methanol to formaldehyde and then to a ketose phosphate such as hexulose 6-phosphate or then to DHA and G3P. When expressed in cells, the fusion proteins can promote methanol uptake and rapid conversion to the ketose phosphate or to the DHA and D3P, which in turn can be used in a pathway for the production of a desired bioproduct. Beneficially, the rapid conversion to the ketose phosphate or to the DHA and G3P can avoid the undesirable accumulation of formaldehyde in the cell.

Abstract: A climate-control system includes a first compressor, a second compressor, a first heat exchanger, a second heat exchanger, and a third heat exchanger. The first compressor includes a first inlet and a first outlet. The second compressor is in fluid communication with the first compressor and includes a second inlet (e.g., a suction inlet), a third inlet (e.g., a vapor-injection inlet), a second compression mechanism, and a second outlet. The second and third inlets are fluidly coupled with the second compression mechanism. The second compression mechanism receives working fluid from the first compressor through the third inlet and discharges working fluid through the second outlet of the second compressor. The first and second compressors are in fluid communication with the first, second, and third heat exchangers.

Abstract: A climate-control system includes a working fluid circuit and a storage tank. The working fluid circuit has a first compressor, a first heat exchanger, a second heat exchanger, a flash tank, and a third heat exchanger. The first heat exchanger receives working fluid discharged from the first compressor. The flash tank is disposed downstream the first heat exchanger and includes an inlet and first and second outlets. The first outlet provides working fluid to the third heat exchanger disposed between the flash tank and the first compressor. The second outlet provides working fluid to the first compressor. The storage tank contains phase-change material that is thermally coupled with the second heat exchanger of the working fluid circuit.

Abstract: A climate-control system includes a first working-fluid circuit, a second working-fluid circuit and a first heat exchanger. The first working-fluid circuit includes a first compressor, a second heat exchanger and a first pump. The second heat exchanger is in fluid communication with the first compressor. The first pump receives a first working fluid from the second heat exchanger and circulates the first working fluid through the first working-fluid circuit. The second working-fluid circuit is fluidly isolated from the first working-fluid circuit and includes a second pump and a fourth heat exchanger. The second pump is in fluid communication with the fourth heat exchanger. The first heat exchanger is thermally coupled with the first working-fluid circuit and the second working-fluid circuit.

Abstract: A climate-control system includes a first compressor and a second compressor. The first compressor includes a first inlet and a first outlet. The second compressor is in fluid communication with the first compressor and includes second and third inlets, a second compression mechanism and a second outlet. The second and third inlets are fluidly coupled to the second compression mechanism. The second compression mechanism receives working fluid from the first compressor through the third inlet and discharges working fluid through the second outlet of the second compressor.

Abstract: A climate-control system includes a first working-fluid circuit, a second working-fluid circuit and a first heat exchanger. The first working-fluid circuit includes a first compressor, a second heat exchanger and a first pump. The second heat exchanger is in fluid communication with the first compressor. The first pump receives a first working fluid from the second heat exchanger and circulates the first working fluid through the first working-fluid circuit. The second working-fluid circuit is fluidly isolated from the first working-fluid circuit and includes a second pump and a fourth heat exchanger. The second pump is in fluid communication with the fourth heat exchanger. The first heat exchanger is thermally coupled with the first working-fluid circuit and the second working-fluid circuit.

Abstract: This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a fatty acid or fatty acid derived product, wherein the modified microorganism produces fatty acyl-CoA intermediates via a malonyl-CoA dependent but malonyl-ACP independent mechanism.

Abstract: A climate-control system includes a working fluid circuit and a storage tank. The working fluid circuit has a first compressor, a first heat exchanger, a second heat exchanger, a flash tank, and a third heat exchanger. The first heat exchanger receives working fluid discharged from the first compressor. The flash tank is disposed downstream the first heat exchanger and includes an inlet and first and second outlets. The first outlet provides working fluid to the third heat exchanger disposed between the flash tank and the first compressor. The second outlet provides working fluid to the first compressor. The storage tank contains phase-change material that is thermally coupled with the second heat exchanger of the working fluid circuit.

Abstract: Described herein are fusion proteins including methanol dehydrogenase (MeDH) and at least one other polypeptide such as 3-hexulose-6-phosphate dehydrogenase (HPS) or 6-phospho-3-hexuloisomerase (PHI), such as DHAS synthase or fructose-6-Phosphate aldolase or such as DHA synthase or DHA kinase. In a localized manner, the fusion protein can promote the conversion of methanol to formaldehyde and then to a ketose phosphate such as hexulose 6-phosphate or then to DHA and G3P. When expressed in cells, the fusion proteins can promote methanol uptake and rapid conversion to the ketose phosphate or to the DHA and D3P, which in turn can be used in a pathway for the production of a desired bioproduct. Beneficially, the rapid conversion to the ketose phosphate or to the DHA and G3P can avoid the undesirable accumulation of formaldehyde in the cell.

Abstract: Embodiments herein concern systems, compositions, methods and uses for in vivo selection of optimum target proteins of use in designing genomically-engineered cells or organisms. Some embodiments relate to compositions and methods for generating barcoded constructs of use in systems and methods described.

Abstract: This invention relates generally to the discovery of pyrazole compounds selective for the neurotensin receptor 2 (NTR2) and uses thereof.

Abstract: Embodiments herein concern systems, compositions, methods and uses for in vivo selection of optimum target proteins of use in designing genomically-engineered cells or organisms. Some embodiments relate to compositions and methods for generating barcoded constructs of use in systems and methods described.

Abstract: An earth-boring tool includes a bit body, a plurality of first cutting elements, and a plurality of second cutting elements. Each of the first cutting elements includes a discontinuous phase dispersed within a continuous matrix phase. The discontinuous phase includes a plurality of particles of superabrasive material. Each of the second cutting elements includes a polycrystalline diamond compact or tungsten carbide. A method of forming an earth-boring tool includes disposing a plurality of first cutting elements on a bit body and disposing a second plurality of second cutting elements on the bit body. Another method of foaming an earth-boring tool includes forming a body having a plurality of first cutting elements and a plurality of cutting element pockets and securing each of a plurality of second cutting elements within each of the cutting element pockets.