Abstract: A radiating-sensitive composition and negative-working imageable element includes a free radically polymerizable component, an initiator composition capable of generating radicals sufficient to initiate polymerization of the free radically polymerizable component upon exposure to imaging radiation, a radiation absorbing compound, and particles of a poly(urethane-acrylic) hybrid that are distributed throughout the composition forming an imageable layer in the element. Imaging can be accomplished at a wide range of wavelengths from about 150 to about 1500 nm, and development can be accomplished using an organic solvent-based developer, warm water, plate cleaner, or on-press using a combination of a lithographic printing ink and a fountain solution.

Abstract: A radiation-sensitive composition includes an initiator composition, a radiation absorbing compound, and a particulate primary polymeric binder that has a backbone comprising multiple urethane moieties and further comprises side chains comprising free radically polymerizable groups attached to the backbone. This primary polymeric binder can be used in place of or in addition to a conventional free radically polymerizable component. This composition can be used to provide negative-working imageable elements that can be imaged and developed to provide lithographic printing plates.

Abstract: A radiation-sensitive composition and negative-working imageable element includes a free radically polymerizable component, an initiator composition capable of generating radicals sufficient to initiate polymerization of the free radically polymerizable component upon exposure to imaging radiation, a radiation absorbing compound, and particles of a poly(urethane-acrylic) hybrid that are distributed throughout the composition forming an imageable layer in the element. Imaging can be accomplished at a wide range of wavelengths from about 150 to about 1500 nm, and development can be accomplished using an organic solvent-based developer, warm water, plate cleaner, or on-press using a combination of a lithographic printing ink and a fountain solution.

Abstract: Negative-working imageable elements can be imaged and then developed using a lower pH organic-based single-phase developer that is less toxic and corrosive and that can be more readily disposed of after use. This developer has a pH less than 12 and comprises a) an amphoteric surfactant comprising a nitrogen-containing heterocycle, b) an amphoteric surfactant having two or more nitrogen atoms, or c) an amphoteric surfactant of a) and an amphoteric surfactant of b).

Abstract: A radiation-sensitive composition includes a radically polymerizable component and an initiator composition capable of generating radicals sufficient to initiate polymerization of the radically polymerizable component upon exposure to imaging radiation. This composition also includes a radiation absorbing compound, a polymeric binder having poly(alkylene glycol) side chains, and a nonionic phosphate acrylate that has a molecular weight of at least 250. This composition can be used to prepare a negative-working imageable element that is sensitive to suitable imaging radiation and can be imaged at relatively low energy, developed either on-press or off-press, and then used for printing without a post-exposure baking step.

Abstract: A device includes a light emitting semiconductor device bonded to an optical element. In some embodiments, the optical element may be elongated or shaped to direct a portion of light emitted by the active region in a direction substantially perpendicular to a central axis of the semiconductor light emitting device and the optical element. In some embodiments, the semiconductor light emitting device and optical element are positioned in a reflector or adjacent to a light guide. The optical element may be bonded to the first semiconductor light emitting device by a bond at an interface disposed between the optical element and the semiconductor light emitting device. In some embodiments, the bond is substantially free of organic-based adhesives.

Abstract: The present invention provides an imageable member having an imageable layer including a heat-sensitive ionomer characterized by a net positive or negative charge, and a photothermal conversion material. The photothermal conversion material includes carbonaceous particles having thereon both an organic moiety including an ionic substituent having like charge as the ionomer, and a group represented by the formula —X-[NIon]p-Rterminal; wherein X represents an aromatic group or an alkyl group, NIon represents a non-ionic, non-ionizable group, Rterminal represents hydrogen, an aromatic group, an alkoxy group, or an alkyl group, and p is an integer from 1 to about 500. The heat-sensitive ionomer and modified carbonaceous particles can be formulated in water or water-miscible solvents without agglomeration.

Abstract: A container assembly includes a container bounding a chamber and having a floor. A well is mounted on the floor of the container. The well bounds a compartment that extends below the floor of the container and communicates with the chamber of the container. An anchor has a side wall with a first port opening formed at a first end and a second port opening formed on the side wall or at a second end of the anchor. A fluid passageway extends between the first port opening and the second port opening. At least a portion of the anchor is secured within the compartment of the well such that at least a portion of the second port opening is disposed within the compartment. A dip tube is fluid coupled with the first port opening of the anchor.

Abstract: The present invention provides an imageable element including a lithographic substrate and an imageable layer disposed on the substrate. The imageable layer includes a radically polymerizable component, an initiator system, and a polymeric binder. The imageable element further includes a tetraarylborate salt. The presence of the tetraarylborate salt may provide improved imaging speed and may enhance press life due to better adhesion between the imageable layer and the substrate. The tetraarylborate salt may be present in the imageable layer, an interlayer, or a separate layer between the substrate and the imageable layer. The imageable element may be imaged and mounted on-press without a separate development step.

Abstract: The present invention relates to compounds and methods for synthesizing compounds wherein the compounds exhibit extended circulating half-life in the blood. The increase in circulating half-life is achieved by conjugating polypeptides to binding groups that exhibit high affinity for human serum albumin.

Abstract: A fingernail pick that is removably attachable to a user's fingernail having a primary string contacting portion, an anchor portion which is shaped to fit comfortably and unobtrusively on top of the fingernail, and a mounting portion. The fingernail pick is held in place either by an adhesive, friction between a slot and a cantilevered portion of fingernail, or by a combination of the two. The fingernail pick may be formed in various sizes and shapes or available in custom sizes and shapes for particular users.

Abstract: A negative-working radiation-sensitive composition includes a polymeric binder comprising a polymer backbone and having attached thereto a carbazole derivative represented by the following Structure (I): wherein Y is a direct bond or a linking group, and R1 to R8 are independently hydrogen, or an alkyl, alkenyl, aryl, halo, cyano, alkoxy, acyl, acyloxy, or carboxylate groups, or any adjacent R1 through R8 groups can together form a carbocyclic or heterocyclic group or a fused aromatic ring. The composition can be sensitive to radiation having a maximum wavelength of from about 150 to about 1500 nm, and can be used to prepare negative-working imageable elements that be imaged and developed as lithographic printing plates.

Abstract: Apparatus and methods for conditioning and pre-tensioning soft tissue grafts during joint repair surgery, such as during repair of the anterior cruciate ligament (ACL). The inventive apparatus is advantageously adapted and configured so as to enable a surgeon to independently apply a desired tensile load to individual graft strands or graft bundles of a multi-strand tissue graft. The inventive methods enable each graft strand or bundle to be properly tensioned so as to both “condition” the graft to prevent subsequent stretching, relaxation or elongation following surgery, which can destabilize the joint, and to pre-tension each graft strand or bundle to a predetermined amount so that each contributes to the strength and stability of the joint, thus resulting in a stronger and more durable joint. The tensioning device is advantageously equipped with structure for attachment to a patient's limb during the conditioning and pre-tensioning procedure.

Abstract: The topical administration of statins for the treatment of bone disorders is disclosed.

Abstract: Imageable elements that contain silicate-coated polymer particles in the imageable layer, stacks of these elements, and methods for forming images using these elements are disclosed. The elements do not stick to each other when stacked without interleaving paper, and only one imageable element is lifted at a time when the imageable elements are handled by automatic processing equipment. Blanket piling is not observed when silicate-coated particles are present in the imageable layer.

Abstract: A method for constructing a mirror blank, including arranging hollow glass balls, on a front face sheet, and in close proximity to each other to permit fusing upon expansion; restricting the expansion of the hollow glass balls with a bounding structure during expansion of the hollow glass balls to force the hollow glass balls into a densely packed array of cells; applying heat to soften the hollow glass balls and increase the pressure within the hollow glass balls as the hollow glass balls fuse with each other during expansion, forming cells, wherein as a result of fusing, the hollow glass balls contact the front face sheet as a result of the increased pressure within the hollow glass balls; annealing and cooling the mirror blank to below annealing temperature associated with the hollow glass balls; and venting the cells.

Abstract: The complement system plays an important role in providing resistance to infections and in the pathogenesis of tissue injury. Yet an inappropriate activation of complement can result in a variety of disorders. The present invention provides C1s catalytic site-directed moieties, C1s exosite binding moieties, and bivalent polypeptide inhibitors comprising such moieties, which can be used to treat conditions characterized by inappropriate complement activation.

Abstract: A device includes a light emitting semiconductor device bonded to an optical element. In some embodiments, the optical element may be elongated or shaped to direct a portion of light emitted by the active region in a direction substantially perpendicular to a central axis of the semiconductor light emitting device and the optical element. In some embodiments, the semiconductor light emitting device and optical element are positioned in a reflector or adjacent to a light guide. The optical element may be bonded to the first semiconductor light emitting device by a bond at an interface disposed between the optical element and the semiconductor light emitting device. In some embodiments, the bond is substantially free of organic-based adhesives.

Abstract: A rail bracket mounting system, including a bracket that is attached to a post. The bracket is formed to support the notching of a rail. The end of a rail is then nested into the bracket, and is supported by the bracket. The rail is then secured to the bracket by fasteners such as screws, and a cover may then be placed over the bracket, housing the securing fasteners. The rail may be hollow or solid. A hollow rail may be reinforced along its entire length by the insertion of one or more reinforcing members through a hollow portion of the rail.

Abstract: A method for drilling a borehole employing a drilling fluid including an additive comprising a glucose derivative with pH lowering acid, buffers and surface active agents. The drilling fluid additive preferably exhibits the following properties: activity of approximately 30%–45% in water solution; pH of about 4.5 to 5.5; a light amber to clear liquid appearance and a density of approximately 1.200 grams per cubic centimeter.