Abstract: The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR systems, components, and methods for targeted modification of nucleic acids. Each system includes one or more protein components and one or more nucleic acid components that together target nucleic acids.

Abstract: An exterior shell for an armored cab having a longitudinal axis and a transverse axis is provided. The exterior shell has a right side panel extending parallel to the longitudinal axis, a left side panel extending parallel to the longitudinal axis, and a rear panel extending parallel to the transverse axis. A cab lower surface extends between the right side panel and the left side panel. The cab lower surface has a center tunnel extending along the longitudinal axis with an exterior curvature having a variable radius as the center tunnel extends along the transverse axis of the exterior shell. The center tunnel is configured to act as a pressure vessel in the event of an explosion beneath the armored cab.

Abstract: The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR systems, components, and methods for targeted modification of nucleic acids. Each system includes one or more protein components and one or more nucleic acid components that together target nucleic acids.

Abstract: The present invention relates to nucleases or nucleic acids encoding the nucleases, RNA guides or nucleic acids encoding the RNA guides, processes for characterizing the nucleases and/or RNA guides, compositions comprising the nucleases and/or RNA guides, and kits and/or methods for preparing and/or using the nucleases and/or RNA guides.

Abstract: The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR systems, components, and methods for targeted modification of nucleic acids such as DNA. Each system includes one or more protein components and one or more nucleic acid components that together target nucleic acids.

Abstract: Dual-lumen catheters for actively mixing two or more fluid components such that they react to form a more viscous pre-polymer formulation at or near the distal tip of the catheter are describe herein. The mixing dynamics within the dual-lumen catheter may be varied depending on the relative viscosity of each individual fluid component, as well as the viscosity of the resulting pre-polymer formulation.