Abstract: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

Abstract: A beam delivery system is provided that includes a beam delivery photonic integrated circuit. The beam delivery photonic integrated circuit includes one or more optical inputs; a plurality of waveguide outputs; and a plurality of beam paths. Each beam path connects one of the plurality of waveguide outputs to at least one of the optical inputs. The plurality of waveguide outputs are configured to emit a plurality of parallel beams. The beam delivery photonic integrated circuit is on a chip. The beam delivery system further includes a telecentric optical relay assembly. The telecentric optical relay assembly is configured to receive the plurality of parallel beams provided by the waveguide outputs and focus each received beam on a corresponding one of a plurality of positions of an atomic object confinement apparatus in a telecentric manner.

Abstract: An example medical device includes a device housing configured to be implantable within a patient, the device housing including an internal surface in contact with a voltaic cell of the battery, and a battery external to the device housing and comprising a battery housing configured to be hermetically sealed. The battery is configured to provide electrical power to an electrical component housed within the device housing, and the battery housing is configured to be attached to the device housing. The battery housing includes an internal surface in contact with a voltaic cell of the battery, and an external surface in contact with the biocompatible electrical insulator. an external surface in contact with the biocompatible electrical insulator.

Abstract: The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.

Abstract: A superconductor junction includes a normal metal layer having a first side and a second side, an insulating layer overlying the second side of the normal metal layer, and a first superconductor layer formed of a first superconductor material that overlies a side of the insulating layer opposite the side that overlies the normal metal layer. The superconductor junction further includes a second superconductor layer formed of a second superconductor material with a first side overlying a side of the first superconductor material opposite the side that overlies the insulating layer. The second superconductor material has a higher diffusion coefficient than the first superconductor material and/or the second superconductor material has a lower recombination coefficient than the first superconductor metal layer. A normal metal layer quasiparticle trap is coupled to a second side of the second superconductor layer.

Abstract: An implantable medical device configured to provide for an intracardiac function, the implantable medical device comprises a body, a sensor arrangement arranged on the body and configured to receive cardiac sense signals, and a processing circuitry operatively connected to the sensor arrangement. The processing circuitry is configured to process cardiac sense signals received using the sensor arrangement to detect a signal deflection potentially indicative of an atrial event caused by atrial activity to obtain an atrial detection, to detect a signal deflection indicative of a ventricular event caused by ventricular activity succeeding said atrial detection, to determine an atrial-ventricular interval representing a time between the atrial detection and the ventricular event, and to identify the atrial detection as valid or invalid based on the atrial-ventricular interval.

Abstract: An implantable medical device configured to provide for an intracardiac function comprises a body, a sensor arrangement arranged on the body and configured to receive a cardiac sense signal, and a processing circuitry operatively connected to the sensor arrangement. The processing circuitry is configured to process the cardiac sense signal received using the sensor arrangement to detect, in a cardiac cycle, a first atrial event candidate based on a comparison of the cardiac sense signal with a sense threshold, to determine a modified sense threshold, to monitor, by comparing the cardiac sense signal to said modified sense threshold following the detection of the first atrial event candidate, whether in the same cardiac cycle a second atrial event candidate is detected.

Abstract: Multilayer films and adhesive tapes that include such films, wherein the multilayer films include plasticized polyvinyl chloride and optionally one or more fillers.

Abstract: A method of manufacturing a semiconductor device is provided. The method includes forming a first trench partially through a first substrate from a first side of the first substrate. The method also includes widening a bottom portion of the first trench to form a lateral footing area of the first trench. The method includes forming a first metallization in the first trench; forming a second trench through a second substrate from a second side of the second substrate to expose at least a portion of first metallization in an area corresponding to the lateral footing area of the first trench, the second side being opposite to the first side. The method also includes forming a second metallization in the second trench in contact with the first metallization.

Abstract: A biosensor inserter includes a push member with a push element, a contact member including a latch, a transmitter carrier supporting a transmitter and sensor assembly, and a pivot member having a latch end, the pivot member supporting an insertion device during biosensor insertion. In operation, the push member is telescoped axially by the user relative to the contact member, which is provided in contact with a user's skin. This pushes the push element against the pivot member and translates the transmitter carrier during insertion of the biosensor. During a first portion of a stroke of the insertion device, insertion of the biosensor is accomplished, and the pivot member is prevented from pivoting. In a second portion of the stroke, after latch end moves past the latch, the pivot member is allowed to pivot and the insertion device is retracted. Other system and method embodiments are provided.

Abstract: Methods for treating joint diseases, disorders, and conditions, such as osteoarthritis, with a composition containing a therapeutically effective amount of tissue inhibitors of matrix metalloproteinases (TIMPs) are provided. The composition can contain TIMPs as part of amniotic fluid, or the TIMPs can be isolated from another source or recombinantly produced. The methods are particularly useful for treating osteoarthritis associated with degradation of articular cartilage by proteases. Also provided are methods of lubricating a joint, such as an osteoarthritic joint.

Abstract: Visco-supplement compositions derived from a transcellular fluid, such as human amniotic fluid, human aqueous humor fluid, or human vitreous fluid are described. Also described are methods for treating inflammatory conditions of the musculoskeletal system, such as joint inflammation, and methods of lubricating a joint using the described visco-supplement compositions.

Abstract: A device configured to receive a request for processing a digital document that identifies a target data structure. The device is further configured to obtain the digital document and to process the digital document to identify objects within the digital document. The device is further configured to input the digital document into a machine learning model that is configured to output contextual metadata for the digital document based on the digital document. The contextual metadata describes attributes of the identified objects within the digital document. The device is further configured to populate a first subset of entries in the target data structure with identifiers for the objects identified within the digital document and to populate a second subset of entries in the target data structure with the contextual metadata. The device is further configured to send the populated target data structure to the network device.

Abstract: Techniques are disclosed relating to biometric authentication, e.g., facial recognition. In some embodiments, a device is configured to verify that image data from a camera unit exhibits a pseudo-random sequence of image capture modes and/or a probing pattern of illumination points (e.g., from lasers in a depth capture mode) before authenticating a user based on recognizing a face in the image data. In some embodiments, a secure circuit may control verification of the sequence and/or the probing pattern. In some embodiments, the secure circuit may verify frame numbers, signatures, and/or nonce values for captured image information. In some embodiments, a device may implement one or more lockout procedures in response to biometric authentication failures. The disclosed techniques may reduce or eliminate the effectiveness of spoofing and/or replay attacks, in some embodiments.

Abstract: A device configured to receive a request for processing a digital document that identifies a target data structure. The device is further configured to obtain the digital document and to process the digital document to identify objects within the digital document. The device is further configured to input the digital document into a machine learning model that is configured to output contextual metadata for the digital document based on the digital document. The contextual metadata describes attributes of the identified objects within the digital document. The device is further configured to populate a first subset of entries in the target data structure with identifiers for the objects identified within the digital document and to populate a second subset of entries in the target data structure with the contextual metadata. The device is further configured to send the populated target data structure to the network device.

Abstract: An apparatus for transferring virtual resources comprises a processor associated with a server. The processor is configured to conduct an interaction between a first user and an entity to transfer a physical object and a non-fungible token (NFT) to the first user, wherein the NFT is associated with the physical object. The processor is further configured to receive the NFT for storage in a first digital folder and to receive a request to establish an interaction session between a first avatar in a virtual environment and a second avatar associated with a second user. The processor is further configured to authorize the interaction session in response to authenticating the NFT and to conduct the interaction. The interaction includes initiating a transfer of the physical object from the first user to the second user and transmitting the NFT to a second digital folder associated with the second user.

Abstract: An apparatus for transferring virtual resources comprises a processor associated with a server. The processor is configured to receive a request from a second user device associated with a second user to establish an interaction session between a first avatar associated with a first user in a virtual environment and a second avatar associated with the second user in the virtual environment. The processor is further configured to authenticate a non-fungible token (NFT) based on data stored in the NFT, wherein the data stored in the NFT is associated with a physical object. The processor is further configured to authorize the interaction session between the first avatar and the second avatar in response to authenticating the NFT and to conduct an interaction between the first avatar and the second avatar to transfer the NFT to a second digital folder associated with the second user.

Abstract: An apparatus for geotagging users for authentication comprises a processor associated with a server. The processor is configured to generate a first geotag based on residence information associated with a first user and to transmit the first geotag to a first user device for assignment to a first avatar associated with the first user in a virtual environment. The processor is further configured to receive an interaction request to authorize an interaction between the first avatar and a second avatar associated with a second user. The processor is further configured to compare a first historical log to a second historical log to determine that the first avatar is associated with the first user. In response to determining that the first avatar is associated with the first user, the processor is further configured to conduct a first step in authorizing the interaction between the first avatar and the second avatar.

Abstract: A system for producing and transmitting encrypted data from data encoded on a storage medium comprises an apparatus configured to receive the storage medium and an encryption chip communicatively coupled to the apparatus. The apparatus comprises a processor, a memory, and a network interface. The processor is configured to receive data encoded into the storage medium, and to decode the received data as the storage medium is at least partially inserted into the apparatus. The processor is further configured to transmit the received data to the memory for storage. The encryption chip comprises an encryption processor configured to access the received data stored in the memory of the apparatus and encrypt the received data with an algorithm to produce the encrypted data. The processor then transmits the encrypted data to an external server communicatively connected to a communication network.

Abstract: An information security system that includes a data control engine configured to receive a data file and to segment the data file into a set of data blocks that each contain a portion of data from the data file. The data control engine is further configured to associate the set of data blocks with a reference tag and to store an association between the set of data blocks and the reference tag. The data control engine is further configured to identify an access key for encrypting each data block, to encrypt each data block with a corresponding access key, and to store an association between each data block and each corresponding access key. The data control engine is further configured to store each data block in a memory and to store location information identifying the location of each data block in the memory.