Patents by Inventor Rachel E. Haurwitz

Rachel E. Haurwitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS OF NUCLEIC ACID-TARGETING NUCLEIC ACIDS
    Publication number: 20220282244
    Abstract: This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof. Genome engineering can refer to altering the genome by deleting, inserting, mutating, or substituting specific nucleic acid sequences. The altering can be gene or location specific. Genome engineering can use nucleases to cut a nucleic acid thereby generating a site for the alteration. Engineering of non-genomic nucleic acid is also contemplated.
    Type: Application
    Filed: August 20, 2021
    Publication date: September 8, 2022
    Inventors: Andrew Paul MAY, Rachel E. Haurwitz, Jennifer A. Doudna, James M. Berger, Matthew Merrill Carter, Paul Daniel Donohoue
  • Compositions and methods of nucleic acid-targeting nucleic acids
    Patent number: 11312953
    Abstract: This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: April 26, 2022
    Assignee: Caribou Biosciences, Inc.
    Inventors: Andrew Paul May, Rachel E. Haurwitz, Jennifer A. Doudna, James M. Berger, Matthew Merrill Carter, Paul Daniel Donohoue
  • Methods of modifying a target nucleic acid with an Argonaute
    Patent number: 10125375
    Abstract: This disclosure provides for compositions and methods for the use of designed nucleic acid-targeting nucleic acids, Argonautes, and complexes thereof.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: November 13, 2018
    Assignee: Caribou Biosciences, Inc.
    Inventors: John Van Der Oost, Daniël Christianus Swarts, Andrew Paul May, Rachel E. Haurwitz
  • Compositions and methods of nucleic acid-targeting nucleic acids
    Patent number: 10125361
    Abstract: This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: November 13, 2018
    Assignee: Caribou Biosciences, Inc.
    Inventors: Andrew Paul May, Rachel E. Haurwitz, Jennifer A. Doudna, James M. Berger, Matthew Merrill Carter, Paul Daniel Donohoue
  • Compositions and Methods of Nucleic Acid-Targeting Nucleic Acids
    Publication number: 20180237770
    Abstract: This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof. Genome engineering can refer to altering the genome by deleting, inserting, mutating, or substituting specific nucleic acid sequences. The altering can be gene or location specific. Genome engineering can use nucleases to cut a nucleic acid thereby generating a site for the alteration. Engineering of non-genomic nucleic acid is also contemplated.
    Type: Application
    Filed: February 23, 2018
    Publication date: August 23, 2018
    Inventors: Andrew Paul May, Rachel E. Haurwitz, Jennifer A. Doudna, James M. Berger, Matthew Merrill Carter, Paul Daniel Donohoue
  • METHODS OF MODIFYING A TARGET NUCLEIC ACID WITH AN ARGONAUTE
    Publication number: 20180171359
    Abstract: This disclosure provides for compositions and methods for the use of designed nucleic acid-targeting nucleic acids, Argonautes, and complexes thereof.
    Type: Application
    Filed: December 21, 2017
    Publication date: June 21, 2018
    Inventors: John Van Der Oost, Daniël Christianus Swarts, Andrew Paul May, Rachel E. Haurwitz
  • METHODS FOR INCREASING CAS9-MEDIATED ENGINEERING EFFICIENCY
    Publication number: 20180171360
    Abstract: Methods for use with Type II CRISPR-Cas9 systems for increasing Cas9-mediated genome engineering efficiency are disclosed. The methods can be used to decrease the number of off-target nucleic acid double-stranded breaks and/or to enhance homology-directed repair of a cleaved target nucleic acid.
    Type: Application
    Filed: February 2, 2018
    Publication date: June 21, 2018
    Inventors: Peter Sean Cameron, Rachel E. Haurwitz, Andrew P. May, Christopher H. Nye, Megan van Overbeek
  • Methods for increasing CAS9-mediated engineering efficiency
    Patent number: 9970030
    Abstract: Methods for use with Type II CRISPR-Cas9 systems for increasing Cas9-mediated genome engineering efficiency are disclosed. The methods can be used to decrease the number of off-target nucleic acid double-stranded breaks and/or to enhance homology-directed repair of a cleaved target nucleic acid.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: May 15, 2018
    Assignee: Caribou Biosciences, Inc.
    Inventors: Peter Sean Cameron, Rachel E. Haurwitz, Andrew P. May, Christopher H. Nye, Megan van Overbeek
  • Compositions and methods of nucleic acid-targeting nucleic acids
    Patent number: 9909122
    Abstract: This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: March 6, 2018
    Assignee: Caribou Biosciences, Inc.
    Inventors: Andrew Paul May, Rachel E. Haurwitz, Jennifer A. Doudna, James M. Berger, Matthew Merrill Carter, Paul Donohoue
  • Methods of modifying a target nucleic acid with an argonaute
    Patent number: 9902973
    Abstract: This disclosure provides for compositions and methods for the use of designed nucleic acid-targeting nucleic acids, Argonautes, and complexes thereof.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: February 27, 2018
    Assignee: Caribou Biosciences, Inc.
    Inventors: John Van Der Oost, Daniël Christianus Swarts, Andrew Paul May, Rachel E. Haurwitz
  • Compositions And Methods Of Nucleic Acid-Targeting Nucleic Acids
    Publication number: 20170327820
    Abstract: This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof.
    Type: Application
    Filed: July 26, 2017
    Publication date: November 16, 2017
    Inventors: Andrew Paul May, Rachel E. Haurwitz, Jennifer A. Doudna, James M. Berger, Matthew Merrill Carter, Paul Daniel Donohoue
  • Compositions and methods of nucleic acid-targeting nucleic acids
    Patent number: 9809814
    Abstract: This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: November 7, 2017
    Assignee: Caribou Biosciences, Inc.
    Inventors: Andrew Paul May, Rachel E. Haurwitz, Jennifer A. Doudna, James M. Berger, Matthew Merrill Carter, Paul Daniel Donohoue
  • Compositions and methods of nucleic acid-targeting nucleic acids
    Patent number: 9803194
    Abstract: This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: October 31, 2017
    Assignee: Caribou Biosciences, Inc.
    Inventors: Andrew Paul May, Rachel E. Haurwitz, Jennifer A. Doudna, James M. Berger, Matthew Merrill Carter, Paul Daniel Donohoue
  • Methods and compositions for controlling gene expression by RNA processing
    Patent number: 9745610
    Abstract: The present disclosure provides nucleic acids encoding an RNA recognition sequence positioned proximal to an insertion site for the insertion of a sequence of interest; and host cells genetically modified with the nucleic acids. The present disclosure also provides methods of modifying the activity of a target RNA, and kits and compositions for carrying out the methods.
    Type: Grant
    Filed: April 9, 2014
    Date of Patent: August 29, 2017
    Assignee: The Regents of the University of California
    Inventors: Jennifer A. Doudna, Lei S. Qi, Rachel E. Haurwitz, Adam P. Arkin
  • Compositions and methods of nucleic acid-targeting nucleic acids
    Patent number: 9725714
    Abstract: This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: August 8, 2017
    Assignee: Caribou Biosciences, Inc.
    Inventors: Andrew Paul May, Rachel E. Haurwitz, Jennifer A. Doudna, James M. Berger, Matthew Merrill Carter, Paul Daniel Donohoue
  • Endoribonuclease compositions and methods of use thereof
    Patent number: 9708646
    Abstract: The present disclosure provides variant Csy4 endoribonucleases, nucleic acids encoding the variant Csy4 endoribonucleases, and host cells genetically modified with the nucleic acids. The variant Csy4 endoribonucleases find use in a variety of applications, which are also provided. The present disclosure also provides methods of detecting a specific sequence in a target polyribonucleotide; and methods of regulating production of a target RNA in a eukaryotic cell.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: July 18, 2017
    Assignee: The Regents of the University of California
    Inventors: Rachel E. Haurwitz, Jennifer A. Doudna, Blake Wiedenheft, Martin Jinek
  • ENDORIBONUCLEASE COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20170166958
    Abstract: The present disclosure provides variant Csy4 endoribonucleases, nucleic acids encoding the variant Csy4 endoribonucleases, and host cells genetically modified with the nucleic acids. The variant Csy4 endoribonucleases find use in a variety of applications, which are also provided. The present disclosure also provides methods of detecting a specific sequence in a target polyribonucleotide; and methods of regulating production of a target RNA in a eukaryotic cell.
    Type: Application
    Filed: February 10, 2017
    Publication date: June 15, 2017
    Inventors: Rachel E. Haurwitz, Jennifer A. Doudna, Blake Wiedenheft, Martin Jinek
  • RNA Modification to Engineer Cas9 Activity
    Publication number: 20170114334
    Abstract: The disclosure provides for compositions, methods and kits, for reducing off-target effects of genome engineering.
    Type: Application
    Filed: December 26, 2016
    Publication date: April 27, 2017
    Inventors: Andrew Paul May, Paul Daniel Donohoue, Christopher Nye, Euan Slorach, Rachel E. Haurwitz
  • Endoribonuclease compositions and methods of use thereof
    Patent number: 9605246
    Abstract: The present disclosure provides variant Csy4 endoribonucleases, nucleic acids encoding the variant Csy4 endoribonucleases, and host cells genetically modified with the nucleic acids. The variant Csy4 endoribonucleases find use in a variety of applications, which are also provided. The present disclosure also provides methods of detecting a specific sequence in a target polyribonucleotide; and methods of regulating production of a target RNA in a eukaryotic cell.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: March 28, 2017
    Assignee: The Regents of the University of California
    Inventors: Rachel E. Haurwitz, Jennifer A. Doudna, Blake Wiedenheft, Martin Jinek
  • Compositions And Methods Of Nucleic Acid-Targeting Nucleic Acids
    Publication number: 20170051276
    Abstract: This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof.
    Type: Application
    Filed: November 4, 2016
    Publication date: February 23, 2017
    Inventors: Andrew Paul May, Rachel E. Haurwitz, Jennifer A. Doudna, James M. Berger, Matthew Merrill Carter, Paul Daniel Donohoue