Patents by Inventor Rachel Jamison PERRY

Rachel Jamison PERRY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2,4-dinitrophenol formulations and methods using same
    Patent number: 11883369
    Abstract: The present invention includes a low dose and sustained release formulation of a mitochondrial uncoupling agent The compositions of the invention are useful for preventing or treating a disease or disorder, such as non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, insulin resistance and/or diabetes, in a subject in need thereof.
    Type: Grant
    Filed: May 16, 2022
    Date of Patent: January 30, 2024
    Assignee: YALE UNIVERSITY
    Inventors: Gerald I. Shulman, Rachel Jamison Perry
  • Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)
    Patent number: 11484608
    Abstract: The present provides a Positional Isotopomer NMR Tracer Analysis (PINTA) method that can be used to noninvasively assess rates of hepatic mitochondrial oxidation (VCS) and/or pyruvate carboxylase (VPC) flux in a subject. In certain embodiments, the methods utilize a combined NMR/gas chromatography-mass spectrometry analysis of plasma following infusion of [3-13C]lactate and glucose tracer. The method of the invention provides investigators with a tool to non-invasively examine the role of altered hepatic mitochondrial metabolism and study the effects of therapeutic interventions for the treatment of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and type 2 diabetes (T2D).
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: November 1, 2022
    Assignee: YALE UNIVERSITY
    Inventors: Gerald I. Shulman, Rachel Jamison Perry, Gary Cline, Douglas Rothman, Kitt Petersen
  • Novel 2,4-Dinitrophenol Formulations and Methods Using Same
    Publication number: 20220339121
    Abstract: The present invention includes a low dose and sustained release formulation of a mitochondrial uncoupling agent The compositions of the invention are useful for preventing or treating a disease or disorder, such as non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, insulin resistance and/or diabetes, in a subject in need thereof.
    Type: Application
    Filed: May 16, 2022
    Publication date: October 27, 2022
    Inventors: Gerald I. SHULMAN, Rachel Jamison PERRY
  • 2,4-dinitrophenol formulations and methods using same
    Patent number: 11433033
    Abstract: The present invention includes a low dose and sustained release formulation of a mitochondrial uncoupling agent The compositions of the invention are useful for preventing or treating a disease or disorder, such as non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, insulin resistance and/or diabetes, in a subject in need thereof.
    Type: Grant
    Filed: July 22, 2020
    Date of Patent: September 6, 2022
    Assignee: YALE UNIVERSITY
    Inventors: Gerald I. Shulman, Rachel Jamison Perry
  • Novel 2,4-Dinitrophenol Formulations and Methods Using Same
    Publication number: 20200352879
    Abstract: The present invention includes a low dose and sustained release formulation of a mitochondrial uncoupling agent The compositions of the invention are useful for preventing or treating a disease or disorder, such as non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, insulin resistance and/or diabetes, in a subject in need thereof.
    Type: Application
    Filed: July 22, 2020
    Publication date: November 12, 2020
    Inventors: Gerald I. SHULMAN, Rachel Jamison PERRY
  • 2,4-dinitrophenol formulations and methods using same
    Patent number: 10786466
    Abstract: The present invention includes a low dose and sustained release formulation of 2,4-dinitrophenol (DNP). The compositions of the invention are useful for preventing or treating a disease or disorder, such as non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, insulin resistance and/or diabetes, in a subject in need thereof.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: September 29, 2020
    Assignee: Yale University
    Inventors: Gerald I. Shulman, Rachel Jamison Perry
  • Non-Invasive Assessment of Hepatic Mitochondrial Metabolism by Positional Isotopomer NMR Tracer Analysis (PINTA)
    Publication number: 20200246490
    Abstract: The present provides a Positional Isotopomer NMR Tracer Analysis (PINTA) method that can be used to noninvasively assess rates of hepatic mitochondrial oxidation (VCS) and/or pyruvate carboxylase (VPC) flux in a subject. In certain embodiments, the methods utilize a combined NMR/gas chromatography-mass spectrometry analysis of plasma following infusion of [3-13C]lactate and glucose tracer. The method of the invention provides investigators with a tool to non-invasively examine the role of altered hepatic mitochondrial metabolism and study the effects of therapeutic interventions for the treatment of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and type 2 diabetes (T2D).
    Type: Application
    Filed: October 5, 2018
    Publication date: August 6, 2020
    Inventors: Gerald I. Shulman, Rachel Jamison Perry, Gary Cline, Douglas Rothman, Kitt Petersen
  • Novel 2,4-Dinitrophenol Formulations and Methods Using Same
    Publication number: 20160199310
    Abstract: The present invention includes a low dose and sustained release formulation of 2,4-dinitrophenol (DNP). The compositions of the invention are useful for preventing or treating a disease or disorder, such as non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, insulin resistance and/or diabetes, in a subject in need thereof.
    Type: Application
    Filed: August 29, 2014
    Publication date: July 14, 2016
    Inventors: Gerald I. SHULMAN, Rachel Jamison PERRY