Patents by Inventor Rachel Jane Errington
Rachel Jane Errington has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11447638Abstract: The present invention provides di-substituted acetalanthraquinone-based compounds of the Formulae (l)-(IV) that are useful for cellular staining and for light-based detection of biological material, e.g. fluorescence-based detection of biological material. These compounds may be used in hydrolysed or non-hydrolysed form. Also provided is a fluorescent complex that comprises a nucleic acid and an acetalanthraquinone-based compound of the invention; and a method of staining a biological sample comprising cells or other biological material containing nucleic acid, which method comprises contacting the biological sample with an acetalanthraquinone-based compound of the invention. In the Formulae (l)-(IV), A and B are each independently of formula —RaCH2CH(ORb)2; or one of A and B is of formula —RaCH2CH(ORb)2 and the other one is of formula: —NRb2.Type: GrantFiled: June 9, 2017Date of Patent: September 20, 2022Assignee: BIOSTATUS LIMITEDInventors: Paul James Smith, Rachel Jane Errington, Laurence Hylton Patterson, Klaus Pors, Laura Cosentino
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Patent number: 11401234Abstract: An anthraquinone compound of formula I (such as the compounds of formulae II to X) and processes for making the same are provided. Pharmaceutical compositions for use in the treatment of cancer, optionally in combination with an agent capable of reducing the level of oxygenation of a tumour, are also provided. Additionally, an option for combination with chemotherapeutic and radiotherapeutic modalities to enhance overall tumour cell kill is provided. Methods for the detection of cellular hypoxia, both in vivo and in vitro, are additionally provided.Type: GrantFiled: August 19, 2019Date of Patent: August 2, 2022Assignee: ONCOTHERICS VENTURES LIMITEDInventors: Stefan Ogrodzinski, Paul Smith, Stephanie McKeown, Laurence Patterson, Rachel Jane Errington
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Publication number: 20200270200Abstract: An anthraquinone compound of formula I (such as the compounds of formulae II to X) and processes for making the same are provided. Pharmaceutical compositions for use in the treatment of cancer, optionally in combination with an agent capable of reducing the level of oxygenation of a tumour, are also provided. Additionally, an option for combination with chemotherapeutic and radiotherapeutic modalities to enhance overall tumour cell kill is provided. Methods for the detection of cellular hypoxia, both in vivo and in vitro, are additionally provided.Type: ApplicationFiled: August 19, 2019Publication date: August 27, 2020Inventors: Stefan OGRODZINSKI, Paul SMITH, Stephanie MCKEOWN, Laurence PATTERSON, Rachel Jane ERRINGTON
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Patent number: 10385009Abstract: An anthraquinone compound of formula I (such as the compounds of formulae II to X) and processes for making the same are provided. Pharmaceutical compositions for use in the treatment of cancer, optionally in combination with an agent capable of reducing the level of oxygenation of a tumor, are also provided. Additionally, an option for combination with chemotherapeutic and radiotherapeutic modalities to enhance overall tumor cell kill is provided. Methods for the detection of cellular hypoxia, both in vivo and in vitro, are additionally provided.Type: GrantFiled: August 7, 2013Date of Patent: August 20, 2019Assignee: BIOSTATUS LIMITEDInventors: Stefan Ogrodzinski, Paul Smith, Stephanie McKeown, Laurence Patterson, Rachel Jane Errington
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Publication number: 20190249011Abstract: The present invention provides di-substituted acetalanthraquinone-based compounds of the Formulae (l)-(IV) that are useful for cellular staining and for light-based detection of biological material, e.g. fluorescence-based detection of biological material. These compounds may be used in hydrolysed or non-hydrolysed form. Also provided is a fluorescent complex that comprises a nucleic acid and an acetalanthraquinone-based compound of the invention; and a method of staining a biological sample comprising cells or other biological material containing nucleic acid, which method comprises contacting the biological sample with an acetalanthraquinone-based compound of the invention. In the Formulae (l)-(IV), A and B are each independently of formula —RaCH2CH(ORb)2; or one of A and B is of formula —RaCH2CH(ORb)2 and the other one is of formula: —NRb2.Type: ApplicationFiled: June 9, 2017Publication date: August 15, 2019Inventors: Paul James Smith, Rachel Jane Errington, Laurence Hylton Patterson, Klaus Pors, Laura Cosentino
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Patent number: 9759715Abstract: The present invention provides the use of a composition comprising a block polymer as a support matrix in the manipulation, processing or analysis of particles, such as cells and fluorescent beads. In a preferred embodiment, the composition exhibits gel-sol thermoreversibility, micelle formation under gelling conditions, optically compatible, controllable surfactant properties, molecular sieving properties and biocompatibility. Further aspects of the invention provide (a) a support matrix composition comprising a block polymer, fluorescent beads and/or a dye for use in the manipulation, processing or analysis of particles, (b) a multichamber plate coated in a support matrix composition and (c) kits for producing the same.Type: GrantFiled: March 29, 2010Date of Patent: September 12, 2017Assignee: Biostatus LimitedInventors: Paul Smith, Laurence Patterson, Rachel Jane Errington
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Patent number: 9546993Abstract: The invention provides a method for detecting objects in samples. The sample is held in the transmission path of light source to a detector, whereby light from the light source interacts with objects in the sample. The patterns of light incident on the detector subsequent to its interaction with the objects are directly used to determine the presence of objects in the sample.Type: GrantFiled: November 13, 2015Date of Patent: January 17, 2017Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Borivoj Vojnovic, Paul R. Barber, Iestyn Pope, Paul James Smith, Rachel Jane Errington
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Publication number: 20160153959Abstract: The invention provides a method for detecting objects in samples. The sample is held in the transmission path of light source to a detector, whereby light from the light source interacts with objects in the sample. The patterns of light incident on the detector subsequent to its interaction with the objects are directly used to determine the presence of objects in the sample.Type: ApplicationFiled: November 13, 2015Publication date: June 2, 2016Inventors: Borivoj VOJNOVIC, Paul R. BARBER, Iestyn POPE, Paul James SMITH, Rachel Jane ERRINGTON
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Patent number: 9212985Abstract: The invention provides apparatus and methods for detecting objects in samples. The sample is held in the transmission path of light from a light source to a detector, whereby light from the light source interacts with objects in the sample. The patterns of light incident on the detector subsequent to its interaction with the objects are directly used to determine the presence of objects in the sample.Type: GrantFiled: January 22, 2008Date of Patent: December 15, 2015Assignee: ISIS INNOVATION LIMITEDInventors: Borivoj Vojnovic, Paul Richard Barber, Iestyn Pope, Paul James Smith, Rachel Jane Errington
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Publication number: 20150307441Abstract: An anthraquinone compound of formula I (such as the compounds of formulae II to X) and processes for making the same are provided. Pharmaceutical compositions for use in the treatment of cancer, optionally in combination with an agent capable of reducing the level of oxygenation of a tumour, are also provided. Additionally, an option for combination with chemotherapeutic and radiotherapeutic modalities to enhance overall tumour cell kill is provided. Methods for the detection of cellular hypoxia, both in vivo and in vitro, are additionally provided.Type: ApplicationFiled: August 7, 2013Publication date: October 29, 2015Applicant: Biostatus LimitedInventors: Stefan Ogrodzinski, Paul Smith, Stephanie McKeown, Laurence Patterson, Rachel Jane Errington
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Publication number: 20120219470Abstract: The present invention provides the use of a composition comprising a block polymer as a support matrix in the manipulation, processing or analysis of particles, such as cells and fluorescent beads. In a preferred embodiment, the composition exhibits gel-sol thermoreversibility, micelle formation under gelling conditions, optically compatible, controllable surfactant properties, molecular sieving properties and biocompatibility. Further aspects of the invention provide (a) a support matrix composition comprising a block polymer, fluorescent beads and/or a dye for use in the manipulation, processing or analysis of particles, (b) a multichamber plate coated in a support matrix composition and (c) kits for producing the same.Type: ApplicationFiled: March 29, 2010Publication date: August 30, 2012Inventors: Paul Smith, Laurence Patterson, Rachel Jane Errington
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Publication number: 20110136165Abstract: The invention provides apparatus and methods for detecting objects in samples. The sample is held in the transmission path of light from a light source to a detector, whereby light from the light source interacts with objects in the sample. The patterns of light incident on the detector subsequent to its interaction with the objects are directly used to determine the presence of objects in the sample.Type: ApplicationFiled: January 22, 2008Publication date: June 9, 2011Inventors: Borivoj Vojnovic, Paul Richard Barber, Iestyn Pope, Paul James Smith, Rachel Jane Errington
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Patent number: 7723085Abstract: The present invention provides the use of a composition comprising a block polymer as a support matrix in the manipulation, processing or analysis of particles, such as cells and fluorescent beads. In a preferred embodiment, the composition exhibits gel-sol thermoreversibility, micelle formation under gelling conditions, optically compatible, controllable surfactant properties, molecular sieving properties and biocompatibility. Further aspects of the invention provide (a) a support matrix composition comprising a block polymer, fluorescent beads and/or a dye for use in the manipulation, processing or analysis of particles, (b) a multichamber plate coated in a support matrix composition and (c) kits for producing the same.Type: GrantFiled: July 1, 2005Date of Patent: May 25, 2010Assignee: Biostatus LimitedInventors: Paul Smith, Laurence Patterson, Rachel Jane Errington
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Publication number: 20080182287Abstract: The present invention provides the use of a composition comprising a block polymer as a support matrix in the manipulation, processing or analysis of particles, such as cells and fluorescent beads. In a preferred embodiment, the composition exhibits gel-sol thermoreversibility, micelle formation under gelling conditions, optically compatible, controllable surfactant properties, molecular sieving properties and biocompatibility. Further aspects of the invention provide (a) a support matrix composition comprising a block polymer, fluorescent beads and/or a dye for use in the manipulation, processing or analysis of particles, (b) a multichamber plate coated in a support matrix composition and (c) kits for producing the same.Type: ApplicationFiled: July 1, 2005Publication date: July 31, 2008Applicant: BIOSTATUS LIMITEDInventors: Paul Smith, Laurence Patterson, Rachel Jane Errington