Patents by Inventor Rachel Lubong SABADO

Rachel Lubong SABADO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF INDUCING NEOEPITOPE-SPECIFIC T CELLS WITH A PD-1 AXIS BINDING ANTAGONIST AND AN RNA VACCINE
    Publication number: 20220378910
    Abstract: The present disclosure provides methods for inducing neoepitope-specific CD8+ T cells in an individual or for inducing trafficking of neoepitope-specific CD8+ T cells to a tumor in an individual using an RNA vaccine or using an RNA vaccine in combination with a PD-1 axis binding antagonist. Also provided herein are PD-1 axis binding antagonists and RNA vaccines that include one or more polynucleotides encoding one or more neoepitopes resulting from cancer-specific somatic mutations present in a tumor specimen obtained from the individual for use in methods of inducing neoepitope-specific CD8+ T cells in an individual or for inducing trafficking of neoepitope-specific CD8+ T cells to a tumor in an individual.
    Type: Application
    Filed: June 30, 2022
    Publication date: December 1, 2022
    Applicants: Genentech, Inc., BioNTech SE, Hoffmann-La Roche Inc.
    Inventors: Lars MUELLER, Rachel Lubong SABADO, Mahesh YADAV, Jingbin ZHANG, Ugur SAHIN