Abstract: A compute device may include circuitry configured to obtain patient state data that may be indicative of a heart rate of the patient or a respiration rate of the patient. The circuitry may also be configured to obtain patient medication data indicative of a schedule for administration of pain medication to the patient. Further, the circuitry may be configured to determine whether a trend in the patient state data satisfies a predefined condition, determine whether the patient medication data indicates that the patient is due for administration of pain medication within a predefined time period, determine, in response to a determination that the trend in the patient state data satisfies the predefined condition and a determination that the patient is due for administration of pain medication within the predefined time period, that the patient is experiencing pain, and produce an alert signal that the patient is in pain.