Patents by Inventor Rachel M. Ostroff
Rachel M. Ostroff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220065872Abstract: The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of non-small cell lung cancer and general cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose non-small cell lung cancer or general cancer. In another aspect, methods are provided for diagnosing non-small cell lung cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, wherein the individual is classified as having lung cancer, or the likelihood of the individual having lung cancer is determined, based on the at least one biomarker value.Type: ApplicationFiled: September 21, 2021Publication date: March 3, 2022Applicant: SomaLogic, Inc.Inventors: Michael RIEL-MEHAN, Alex A. E. STEWART, Rachel M. OSTROFF, Stephen Alaric WILLIAMS, Edward N. Brody
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Patent number: 11041866Abstract: The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer generally and pancreatic cancer specifically. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to diagnose cancer generally or pancreatic cancer specifically. In another aspect, methods are provided for diagnosing pancreatic cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, wherein the individual is classified as having pancreatic cancer, or the likelihood of the individual having pancreatic cancer is determined, based on the at least one biomarker value.Type: GrantFiled: August 17, 2017Date of Patent: June 22, 2021Assignee: SomaLogic, Inc.Inventors: Stephen Alaric Williams, Michael Riel-Mehan, Rachel M. Ostroff
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Patent number: 10359425Abstract: The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of lung cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose lung cancer or permit the differential diagnosis of pulmonary nodules as benign or malignant. In another aspect, methods are provided for diagnosing lung cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, Col. 2, wherein the individual is classified as having lung cancer, or the likelihood of the individual having lung cancer is determined, based on the at least one biomarker value.Type: GrantFiled: September 9, 2009Date of Patent: July 23, 2019Assignee: SomaLogic, Inc.Inventors: Larry Gold, Marty Stanton, Edward N. Brody, Rachel M. Ostroff, Dominic Zichi, Alex A. E. Stewart
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Publication number: 20180045739Abstract: The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer generally and pancreatic cancer specifically. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to diagnose cancer generally or pancreatic cancer specifically. In another aspect, methods are provided for diagnosing pancreatic cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, wherein the individual is classified as having pancreatic cancer, or the likelihood of the individual having pancreatic cancer is determined, based on the at least one biomarker value.Type: ApplicationFiled: August 17, 2017Publication date: February 15, 2018Inventors: Stephen Alaric Williams, Michael Riel-Mehan, Rachel M. Ostroff
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Patent number: 9423403Abstract: Methods, compositions, and kits for predicting whether a subject with chronic obstructive pulmonary disease (COPD) or at risk of developing COPD is likely to have progressive COPD are provided. Methods, compositions, and kits for predicting whether lung function is likely to decline in a subject with COPD or at risk for developing COPD are also provided.Type: GrantFiled: June 30, 2015Date of Patent: August 23, 2016Assignee: SomaLogic, Inc.Inventors: Malti P. Nikrad, Stuart G. Field, Stephen Alaric Williams, Alex A. E. Stewart, Rachel M. Ostroff, Rosalynn Dianne Gill
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Publication number: 20150377903Abstract: Methods, compositions, and kits for predicting whether a subject with chronic obstructive pulmonary disease (COPD) or at risk of developing COPD is likely to have progressive COPD are provided. Methods, compositions, and kits for predicting whether lung function is likely to decline in a subject with COPD or at risk for developing COPD are also provided.Type: ApplicationFiled: June 30, 2015Publication date: December 31, 2015Inventors: Malti P. Nikrad, Stuart G. Field, Stephen Alaric Williams, Alex A.E. Stewart, Rachel M. Ostroff, Rosalynn Dianne Gill
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Patent number: 9103837Abstract: Methods, compositions, and kits for predicting whether a subject with chronic obstructive pulmonary disease (COPD) or at risk of developing COPD is likely to have progressive COPD are provided. Methods, compositions, and kits for predicting whether lung function is likely to decline in a subject with COPD or at risk for developing COPD are also provided.Type: GrantFiled: November 7, 2013Date of Patent: August 11, 2015Assignee: SOMALOGIC, INC.Inventors: Malti P. Nikrad, Stuart G. Field, Stephen Alaric Williams, Alex A. E. Stewart, Rachel M. Ostroff, Rosalynn Dianne Gill
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Publication number: 20150160225Abstract: The subject disclosure concerns methods for evaluation of renal cell carcinoma (RCC). Such methods include a method of determining of a diagnosis of the individual as having or not having RCC; determination of a prognosis of a future course of RCC; determination of disease burden; or determination of recurrence of RCC in an individual who had been apparently cured of RCC. The methods each involve the detection of the value of at least one biomarker of Table 1. The biomarker value is used, in some of the methods, to determine whether the individual does or does not demonstrate evidence of disease, and in another method, to determine the degree or a score indicative of the individual's extent of disease.Type: ApplicationFiled: December 10, 2014Publication date: June 11, 2015Inventors: Rachel M. Ostroff, Stephen Alaric Williams, Michael Riel-Mehan, Edward N. Brody, Alex A.E. Stewart, Shintaro Kato
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Publication number: 20140135302Abstract: Methods, compositions, and kits for predicting whether a subject with chronic obstructive pulmonary disease (COPD) or at risk of developing COPD is likely to have progressive COPD are provided. Methods, compositions, and kits for predicting whether lung function is likely to decline in a subject with COPD or at risk for developing COPD are also provided.Type: ApplicationFiled: November 7, 2013Publication date: May 15, 2014Applicant: SOMALOGIC, INC.Inventors: Malti P. Nikrad, Stuart G. Field, Stephen Alaric Williams, Alex A.E. Stewart, Rachel M. Ostroff, Rosalynn Dianne Gill
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Publication number: 20140073521Abstract: The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer. In one aspect, methods are provided for diagnosing mesothelioma where the methods include detecting, in a biological sample, at least one biomarker value corresponding to at least one biomarker selected from the biomarkers provided in Table 1, wherein an individual is classified as having mesothelioma, or the likelihood of an individual having mesothelioma is determined, based on the at least one biomarker value. In another aspect, methods are provided for diagnosing cancer generally where the methods include detecting, in a biological sample at least one biomarker value corresponding to at least one biomarker selected from the biomarkers provided in Table 17, wherein an individual is classified as having cancer generally, or the likelihood of an individual having cancer is determined, based on the at least one biomarker value.Type: ApplicationFiled: September 3, 2013Publication date: March 13, 2014Applicant: SomaLogic, Inc.Inventors: Rachel M. Ostroff, Alex A.E. Stewart, Stephen Alaric Williams, Edward N. Brody, Malti Nikrad, Michael Riel-Mehan
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Publication number: 20140073522Abstract: The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer generally and pancreatic cancer specifically. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to diagnose cancer generally or pancreatic cancer specifically. In another aspect, methods are provided for diagnosing pancreatic cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, wherein the individual is classified as having pancreatic cancer, or the likelihood of the individual having pancreatic cancer is determined, based on the at least one biomarker value.Type: ApplicationFiled: September 6, 2013Publication date: March 13, 2014Applicant: SomaLogic, Inc.Inventors: Stephen Alaric Williams, Michael Riel-Mehan, Rachel M. Ostroff
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Publication number: 20130065782Abstract: The subject disclosure concerns methods for evaluation of renal cell carcinoma (RCC). Such methods include a method of determining of a diagnosis of the individual as having or not having RCC; determination of a prognosis of a future course of RCC; determination of disease burden; or determination of recurrence of RCC in an individual who had been apparently cured of RCC. The methods each involve the detection of the value of at least one biomarker of Table 1. The biomarker value is used, in some of the methods, to determine whether the individual does or does not demonstrate evidence of disease, and in another method, to determine the degree or a score indicative of the individual's extent of disease.Type: ApplicationFiled: August 22, 2012Publication date: March 14, 2013Applicant: SOMALOGIC, INC.Inventors: Rachel M. Ostroff, Stephen Alaric Williams, Michael Riel-Mehan, Edward N. Brody, Alex A.E. Stewart, Shintaro Kato
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Publication number: 20120165217Abstract: The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to diagnose cancer. In another aspect, methods are provided for diagnosing cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 24, wherein the individual is classified as having cancer, or the likelihood of the individual having cancer is determined, based on the at least one biomarker value.Type: ApplicationFiled: April 3, 2010Publication date: June 28, 2012Applicant: SOMALOGIC, INC.Inventors: Larry Gold, Edward N. Brody, Rachel M. Ostroff, Dominic Zichi, Alex A.E. Stewart, Michael Riel-Mehan, Mark Messenbaugh, Randee S. Schwartz, Jeffery Walker, Stephen Alaric Williams, Malti Nikrad
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Publication number: 20120143805Abstract: The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to diagnose cancer. In another aspect, methods are provided for diagnosing cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 47, wherein the individual is classified as having cancer, or the likelihood of the individual having cancer is determined, based on the at least one biomarker value.Type: ApplicationFiled: March 5, 2010Publication date: June 7, 2012Applicant: SOMALOGIC, INC.Inventors: Larry Gold, Edward N. Brody, Rachel M. Ostroff, Dominic Zichi, Alex A.E. Stewart, Michael Riel-Mehan, Mark Messenbaugh, Randee S. Schwartz, Jeffery Walker, Stephen Alaric Williams, Malti Nikrad
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Publication number: 20120101002Abstract: The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of non-small cell lung cancer and general cancer. In one aspect, methods are provided for diagnosing non-small cell lung cancer, where the methods include detecting, in a sample, at least one biomarker value corresponding to at least one biomarker selected from the biomarkers provided in Table 1, wherein an individual is classified as having lung cancer, or the likelihood of having lung cancer is determined, based on the at least one biomarker value. In another aspect, methods are provided for diagnosing cancer, where the methods include detecting, in a sample, at least one biomarker value corresponding to at least one biomarker selected from the biomarkers provided in Table 19, wherein an individual is classified as having cancer, or the likelihood of having cancer is determined, based on the at least one biomarker value.Type: ApplicationFiled: October 24, 2011Publication date: April 26, 2012Applicant: SomaLogic, Inc.Inventors: Michael Riel-Mehan, Alex A.E. Stewart, Rachel M. Ostroff, Stephen Alaric Williams, Edward N. Brody
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Publication number: 20120077695Abstract: The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer. In one aspect, methods are provided for diagnosing mesothelioma where the methods include detecting, in a biological sample, at least one biomarker value corresponding to at least one biomarker selected from the biomarkers provided in Table 1, wherein an individual is classified as having mesothelioma, or the likelihood of an individual having mesothelioma is determined, based on the at least one biomarker value. In another aspect, methods are provided for diagnosing cancer generally where the methods include detecting, in a biological sample at least one biomarker value corresponding to at least one biomarker selected from the biomarkers provided in Table 17, wherein an individual is classified as having cancer generally, or the likelihood of an individual having cancer is determined, based on the at least one biomarker value.Type: ApplicationFiled: September 27, 2011Publication date: March 29, 2012Applicant: SOMALOGIC, INC.Inventors: Rachel M. Ostroff, Alex A.E. Stewart, Stephen Alaric Williams, Edward N. Brody, Malti Nikrad, Michael Riel-Mehan
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Publication number: 20120040861Abstract: The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer generally and pancreatic cancer specifically. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to diagnose cancer generally or pancreatic cancer specifically. In another aspect, methods are provided for diagnosing pancreatic cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, wherein the individual is classified as having pancreatic cancer, or the likelihood of the individual having pancreatic cancer is determined, based on the at least one biomarker value.Type: ApplicationFiled: August 12, 2011Publication date: February 16, 2012Applicant: SOMALOGIC, INC.Inventors: Stephen Alaric Williams, Michael Riel-Mehan, Rachel M. Ostroff
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Publication number: 20100086948Abstract: The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of ovarian cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose ovarian cancer or permit the differential diagnosis of a pelvic mass as benign or malignant. In another aspect, methods are provided for diagnosing ovarian cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, wherein the individual is classified as having ovarian cancer, or the likelihood of the individual having ovarian cancer is determined, based on the at least one biomarker value.Type: ApplicationFiled: October 6, 2009Publication date: April 8, 2010Applicant: SOMALOGIC, INC.Inventors: Larry Gold, Marty Stanton, Edward N. Brody, Rachel M. Ostroff, Dominic Zichi, Alex A.E. Stewart
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Publication number: 20100070191Abstract: The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of lung cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose lung cancer or permit the differential diagnosis of pulmonary nodules as benign or malignant. In another aspect, methods are provided for diagnosing lung cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, Col. 2, wherein the individual is classified as having lung cancer, or the likelihood of the individual having lung cancer is determined, based on the at least one biomarker value.Type: ApplicationFiled: September 9, 2009Publication date: March 18, 2010Applicant: SOMALOGIC, INC.Inventors: Larry Gold, Marty Stanton, Edward N. Brody, Rachel M. Ostroff, Dominic Zichi, Alex A.E. Stewart
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Patent number: 7153651Abstract: An optical assay device for the detection of an analyte of interest in a sample comprising a support containing channels, an optically functional layer positioned on the support such that the optically functional layer and the support allow for laminar flow of the sample through layers of the device, an attachment layer positioned on the optically functional layer, and an analyte specific receptive layer positioned on the attachment layer.Type: GrantFiled: October 15, 1997Date of Patent: December 26, 2006Assignee: Inverness Medical - Biostar, Inc.Inventors: Joel A. Drewes, Gregory R. Bogart, Jeffrey B. Etter, Jeffrey W. Steaffens, Rachel M. Ostroff, Mark Crosby