Patents by Inventor Rachel R. P. Yang

Rachel R. P. Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hypophosphite deoxygenation reactions in the synthesis of erythromycin derivatives
    Patent number: 6040440
    Abstract: A process for the preparation of 4"-deoxyerythromycins, having the formula: ##STR1## wherein R is H or OH, R.sup.1 is H or loweralkyl, and R.sup.2 is H or CH.sub.3 by treatment of the starting material, 2'-O-acetyl-4"-imidazolylthiocarbamoyl-erythromycin, with a hypophosphite reagent, in a water-miscible protic solvent optionally comprising a phase transfer agent. In a preferred embodiment, the water-miscible solvent is an alcohol and the starting material is reacted with sodium hypophosphite, ACVA and tetra-n-butylammonium hydroxide.
    Type: Grant
    Filed: March 6, 1998
    Date of Patent: March 21, 2000
    Assignee: Abbott Laboratories
    Inventors: Alexandra E. Graham, Albert V. Thomas, Rachel R. P. Yang