Patents by Inventor Rachel Rosenthal

Rachel Rosenthal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Analysis of HLA alleles in tumours and the uses thereof
    Patent number: 11634773
    Abstract: The present invention relates to a method for determining whether an HLA allele is lost in a tumour in a subject, wherein said method comprises the step of determining the specific copy number of said HLA allele in said tumour. The invention also relates to a method for treating cancer in a subject, comprising targeting a neoantigen which is predicted to be presented by an HLA molecule encoded by an HLA allele which has been determined not to have been lost in a tumour in said subject.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: April 25, 2023
    Assignees: THE FRANCIS CRICK INSTITUTE LIMITED, UNIVERSITY COLLEGE LONDON, CANCER RESEARCH TECHNOLOGY LIMITED
    Inventors: Charles Swanton, Nicholas McGranahan, Rachel Rosenthal
  • “Immune checkpoint intervention” in cancer
    Patent number: 11098121
    Abstract: The present invention relates to methods for identifying a subject with cancer who is suitable for treatment with an immune checkpoint intervention, and to methods of treatment of such subjects. The invention further relates to a method for predicting or determining the prognosis of a subject with cancer.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: August 24, 2021
    Assignee: CANCER RESEARCH TECHNOLOGY LIMITED
    Inventors: Nicholas McGranahan, Rachel Rosenthal, Charles Swanton, Karl Peggs, Sergio Quezada
  • ANALYSIS OF HLA ALLELES IN TUMOURS AND THE USES THEREOF
    Publication number: 20210147934
    Abstract: The present invention relates to a method for determining whether an HLA allele is lost in a tumour in a subject, wherein said method comprises the step of determining the specific copy number of said HLA allele in said tumour. The invention also relates to a method for treating cancer in a subject, comprising targeting a neoantigen which is predicted to be presented by an HLA molecule encoded by an HLA allele which has been determined not to have been lost in a tumour in said subject.
    Type: Application
    Filed: July 13, 2018
    Publication date: May 20, 2021
    Inventors: Charles Swanton, Nicholas McGranahan, Rachel Rosenthal
  • NEO-ANTIGEN SPECIFIC T CELLS
    Publication number: 20200000904
    Abstract: The present invention relates to a method for identifying a truncal neo-antigen in a tumour from a subject which comprises the steps of: i) determining mutations present in a sample isolated from the tumour; and ii) identifying a truncal mutation which is a mutation present in essentially all tumour cells; and iii) identifying a truncal neo-antigen, which is an antigen encoded by a sequence which comprises the truncal mutation.
    Type: Application
    Filed: September 9, 2019
    Publication date: January 2, 2020
    Inventors: Nicholas McGranahan, Rachel Rosenthal, Charles Swanton, Karl Peggs, Sergio Quezada
  • Method for Treating Cancer
    Publication number: 20200000903
    Abstract: The present invention relates to a method for identifying a truncal neo-antigen in a tumour from a subject which comprises the steps of: i) determining mutations present in a sample isolated from the tumour; and ii) identifying a truncal mutation which is a mutation present in essentially all tumour cells; and iii) identifying a truncal neo-antigen, which is an antigen encoded by a sequence which comprises the truncal mutation.
    Type: Application
    Filed: September 9, 2019
    Publication date: January 2, 2020
    Inventors: Nicholas McGranahan, Rachel Rosenthal, Charles Swanton, Karl Peggs, Sergio Quezada
  • "IMMUNE CHECKPOINT INTERVENTION" IN CANCER
    Publication number: 20180251553
    Abstract: The present invention relates to methods for identifying a subject with cancer who is suitable for treatment with an immune checkpoint intervention, and to methods of treatment of such subjects. The invention further relates to a method for predicting or determining the prognosis of a subject with cancer.
    Type: Application
    Filed: September 12, 2016
    Publication date: September 6, 2018
    Applicant: CANCER RESEARCH TECHNOLOGY LIMITED
    Inventors: Nicholas McGranahan, Rachel Rosenthal, Charles Swanton, Karl Peggs, Sergio Quezada
  • METHOD FOR TREATING CANCER
    Publication number: 20180064793
    Abstract: The present invention relates to a method for identifying a truncal neo-antigen in a tumour from a subject which comprises the steps of: i) determining mutations present in a sample isolated from the tumour; and ii) identifying a truncal mutation which is a mutation present in essentially all tumour cells; and iii) identifying a truncal neo-antigen, which is an antigen encoded by a sequence which comprises the truncal mutation.
    Type: Application
    Filed: April 27, 2016
    Publication date: March 8, 2018
    Inventors: Nicholas Mcgranahan, Rachel Rosenthal, Charles Swanton, Karl Peggs, Sergio Quezada