Patents by Inventor Rachel Sattler

Rachel Sattler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NON-HUMAN ANIMALS COMPRISING A HUMANIZED ALBUMIN LOCUS
    Publication number: 20230232797
    Abstract: Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized albumin (ALB) locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized albumin locus express a human albumin protein or a chimeric albumin protein, fragments of which are from human albumin. Methods are provided for using such non-human animals comprising a humanized albumin locus to assess in vivo efficacy of human-albumin-targeting reagents such as nuclease agents designed to target human albumin.
    Type: Application
    Filed: February 27, 2023
    Publication date: July 27, 2023
    Applicant: Regeneron Pharmaceuticals, Inc.
    Inventors: Qing Fang, Chia-Jen Siao, Dan Chalothorn, KehDih Lai, Leah Sabin, Rachel Sattler, Brian Zambrowicz, Lori Morton
  • Genetically modified mouse that expresses human albumin
    Patent number: 11622547
    Abstract: Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized albumin (ALB) locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized albumin locus express a human albumin protein or a chimeric albumin protein, fragments of which are from human albumin. Methods are provided for using such non-human animals comprising a humanized albumin locus to assess in vivo efficacy of human-albumin-targeting reagents such as nuclease agents designed to target human albumin.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: April 11, 2023
    Assignee: Regeneran Pharmaceuticals, Inc.
    Inventors: Qing Fang, Chia-Jen Siao, Dan Chalothorn, KehDih Lai, Leah Sabin, Rachel Sattler, Brian Zambrowicz, Lori Morton
  • COMPOSITIONS AND METHODS FOR TRANSGENE EXPRESSION FROM AN ALBUMIN LOCUS
    Publication number: 20220354967
    Abstract: The present disclosure is directed to methods and compositions useful for inserting and expressing a heterologous (exogenous) gene within a genomic locus, such as a safe harbor site, of a host cell.
    Type: Application
    Filed: April 16, 2021
    Publication date: November 10, 2022
    Inventors: Jonathan Douglas Finn, Hon-Ren Huang, Moitri Roy, KehDih Lai, Rachel Sattler, Christos Kyratsous, Cheng Wang
  • NON-HUMAN ANIMALS COMPRISING A HUMANIZED ALBUMIN LOCUS
    Publication number: 20200383304
    Abstract: Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized albumin (ALB) locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized albumin locus express a human albumin protein or a chimeric albumin protein, fragments of which are from human albumin. Methods are provided for using such non-human animals comprising a humanized albumin locus to assess in vivo efficacy of human-albumin-targeting reagents such as nuclease agents designed to target human albumin.
    Type: Application
    Filed: June 5, 2020
    Publication date: December 10, 2020
    Inventors: QING FANG, CHIA-JEN SIAO, DAN CHALOTHORN, KEHDIH LAI, LEAH SABIN, RACHEL SATTLER, BRIAN ZAMBROWICZ, LORI MORTON
  • COMPOSITIONS AND METHODS FOR EXPRESSING FACTOR IX
    Publication number: 20200289628
    Abstract: Compositions and methods for expressing Factor IX in a host cell or a population of host cells are provided. Also provided are engineered host cells expressing Factor IX.
    Type: Application
    Filed: October 18, 2019
    Publication date: September 17, 2020
    Inventors: John Finn, Hon-Ren Huang, Moitri Roy, KehDih Lai, Rachel Sattler, Christos Kyratsous, Cheng Wang
  • COMPOSITIONS AND METHODS FOR TRANSGENE EXPRESSION FROM AN ALBUMIN LOCUS
    Publication number: 20200270617
    Abstract: Methods for editing, e.g., introducing a heterologous transgene, within the human albumin gene (e.g., at intron 1) are provided.
    Type: Application
    Filed: October 18, 2019
    Publication date: August 27, 2020
    Inventors: John Finn, Hon-Ren Huang, Moitri Roy, KehDih Lai, Rachel Sattler, Christos Kyratsous, Cheng Wang