Abstract: A jewelry viewing stand including a stand, an imaging device, and an adjustable base is provided. The imaging device is configured to image a piece of jewelry and the stand is configured to hold and position the imaging device. The adjustable base is attached to the stand and positioned beneath the imaging device. The adjustable device is configured to move a piece of jewelry vertically toward and away from the imaging device while the stand maintains the imaging device in a stable, stationary position.

Abstract: A method for coupling a first medical device component to a second medical device component comprising altering the first medical device component from a natural state to an altered state, by reducing a cross-sectional dimension of the first medical device, fitting a first portion of the first medical device component in the altered state into a first opening of the second medical device component, wherein the first medical device component includes second portions not within the first opening of the second medical device component, and allowing the second portions of the first medical device component to revert back to the natural state.

Abstract: Hard-tissue implants are provided that include a bulk implant, a face, pillars, slots, and at least one support member. The pillars are for contacting a hard tissue. The slots are to be occupied by the hard tissue. The at least one support member is for contacting the hard tissue. The hard-tissue implant has a Young's modulus of elasticity of at least 3 GPa, and has a ratio of the sum of (i) the volumes of the slots to (ii) the sum of the volumes of the pillars and the volumes of the slots of 0.40:1 to 0.90:1. Methods of making and using hard-tissue implants are also provided.

Abstract: Hard-tissue implants are provided that include a bulk implant, a face, pillars, slots, and at least one support member. The pillars are for contacting a hard tissue. The slots are to be occupied by the hard tissue. The at least one support member is for contacting the hard tissue. The hard-tissue implant has a Young's modulus of elasticity of at least 3 GPa, and has a ratio of the sum of (i) the volumes of the slots to (ii) the sum of the volumes of the pillars and the volumes of the slots of 0.40:1 to 0.90:1. Methods of making and using hard-tissue implants are also provided.

Abstract: In some embodiments, an electronic device present navigation routes from various perspectives. In some embodiments, an electronic device modifies display of representations of (e.g., physical) objects in the vicinity of a navigation route while presenting navigation directions. In some embodiments, an electronic device modifies display of portions of a navigation route that are occluded by representations of (e.g., physical) objects in a map. In some embodiments, an electronic device presents representations of (e.g., physical) objects in maps. In some embodiments, an electronic device presents representations of (e.g., physical) objects in maps in response to requests to search for (e.g., physical) objects.

Abstract: Spinal interbody cages are provided that include a bulk interbody cage, a top face, a bottom face, pillars, and slots. The pillars are for contacting vertebral bodies. The slots are to be occupied by bone of the vertebral bodies and/or by bone of a bone graft. The spinal interbody cage has a Young's modulus of elasticity of at least 3 GPa, and has a ratio of the sum of (i) the volumes of the slots to (ii) the sum of the volumes of the pillars and the volumes of the slots of 0.40:1 to 0.90:1.

Abstract: Spinal interbody cages are provided that include a bulk interbody cage, a top face, a bottom face, a top mesh structure, a bottom mesh structure, pillars, and slots. The top and bottom faces are exterior surfaces of the bulk interbody cage having a top central opening and a bottom central opening, respectively. The top and bottom mesh structures extend from the bulk interbody cage across the top central opening and the bottom central opening, respectively. The pillars are for contacting vertebral bodies. The slots are to be occupied by bone of the vertebral bodies and/or by bone of a bone graft. The spinal interbody cage has a Young's modulus of elasticity of at least 3 GPa, and has a ratio of the sum of (i) the volumes of the slots to (ii) the sum of the volumes of the pillars and the volumes of the slots of 0.40:1 to 0.90:1.

Abstract: Hard-tissue implants are provided that include a bulk implant, a face, pillars, slots, and at least one support member. The pillars are for contacting a hard tissue. The slots are to be occupied by the hard tissue. The at least one support member is for contacting the hard tissue. The hard-tissue implant has a Young's modulus of elasticity of at least 3 GPa, and has a ratio of the sum of (i) the volumes of the slots to (ii) the sum of the volumes of the pillars and the volumes of the slots of 0.40:1 to 0.90:1. Methods of making and using hard-tissue implants are also provided.

Abstract: Hard-tissue implants are provided that include a bulk implant, a face, pillars, slots, and at least one support member. The pillars are for contacting a hard tissue. The slots are to be occupied by the hard tissue. The at least one support member is for contacting the hard tissue. The hard-tissue implant has a Young's modulus of elasticity of at least 3 GPa, and has a ratio of the sum of (i) the volumes of the slots to (ii) the sum of the volumes of the pillars and the volumes of the slots of 0.40:1 to 0.90:1. Methods of making and using hard-tissue implants are also provided.

Abstract: Spinal interbody cages are provided that include a bulk interbody cage, a top face, a bottom face, a top mesh structure, a bottom mesh structure, pillars, and slots. The top and bottom faces are exterior surfaces of the bulk interbody cage having a top central opening and a bottom central opening, respectively. The top and bottom mesh structures extend from the bulk interbody cage across the top central opening and the bottom central opening, respectively. The pillars are for contacting vertebral bodies. The slots are to be occupied by bone of the vertebral bodies and/or by bone of a bone graft. The spinal interbody cage has a Young's modulus of elasticity of at least 3 GPa, and has a ratio of the sum of (i) the volumes of the slots to (ii) the sum of the volumes of the pillars and the volumes of the slots of 0.40:1 to 0.90:1.

Abstract: Hard-tissue implants are provided that include a bulk implant, a face, pillars, slots, and at least one support member. The pillars are for contacting a hard tissue. The slots are to be occupied by the hard tissue. The at least one support member is for contacting the hard tissue. The hard-tissue implant has a Young's modulus of elasticity of at least 3 GPa, and has a ratio of the sum of (i) the volumes of the slots to (ii) the sum of the volumes of the pillars and the volumes of the slots of 0.40:1 to 0.90:1. Methods of making and using hard-tissue implants are also provided.

Abstract: Orthopedic screws are provided that include a tip, a head, and a shaft extending between the tip and the head. The shaft comprises a shaft core and at least one thread. The thread is disposed helically along the shaft, extends radially from the shaft, and has a plurality of grooves oriented transversely with respect to the thread. The plurality of grooves define a series of thread segments and thread slots along the thread. The shaft core is solid from the tip to the head. Cannulated orthopedic screws also are provided that include a shaft core that is hollow from the tip to the head and that defines a lumen extending from a tip opening to a head opening. Methods of use of the orthopedic screws and the cannulated orthopedic screws also are provided.

Abstract: Spinal interbody cages are provided that include a bulk interbody cage, a top face, a bottom face, pillars, and slots. The pillars are for contacting vertebral bodies. The slots are to be occupied by bone of the vertebral bodies and/or by bone of a bone graft. The spinal interbody cage has a Young's modulus of elasticity of at least 3 GPa, and has a ratio of the sum of (i) the volumes of the slots to (ii) the sum of the volumes of the pillars and the volumes of the slots of 0.40:1 to 0.90:1.

Abstract: A 3D printer may precisely control deposition of diffusible chemical signals in different spatial regions of a solid polymer structure, in such a way that the concentration and spatial distribution of each diffusible chemical signal in each spatial region of the structure is independently controlled. A hydrogel containing genetically engineered, living organisms may be applied to a surface of the solid polymer structure. The living organisms may be single-celled organisms, such as bacteria. The diffusible chemical signals may diffuse out of the solid polymer structure and into the hydrogel, and may control gene expression of genetically engineered cells in different spatial locations in the hydrogel. Thus, gene expression of genetically-engineered cells in a hydrogel may be controlled on a region-by-region basis, by precisely controlling the position and concentration of diffusible chemical signals that are initially embedded in a solid structure adjacent to the hydrogel.

Abstract: The present disclosure relates generally to methods for the increased processing of tissue for the generation of cardiac stem cells, wherein the stem cells are suitable for use in cardiac stem cell therapy. In particular, several embodiments relate to the processing of allogeneic donor cardiac tissue for the generation of multiple patient doses of cardiac stem cells.

Abstract: The present disclosure relates generally to methods for the increased processing of tissue for the generation of cardiac stem cells, wherein the stem cells are suitable for use in cardiac stem cell therapy. In particular, several embodiments relate to the processing of allogeneic donor cardiac tissue for the generation of multiple patient doses of cardiac stem cells.

Abstract: The present disclosure relates generally to methods for the increased processing of tissue for the generation of cardiac stem cells, wherein the stem cells are suitable for use in cardiac stem cell therapy. In particular, several embodiments relate to the processing of allogeneic donor cardiac tissue for the generation of multiple patient doses of cardiac stem cells.

Abstract: The invention encompasses methods for generating stable exosome formulations and encompasses stable exosome formulations. The exosome formulations encompass stable liquid exosome formulations and stable lyophilized exosome formulations. In some embodiments, the exosome formulations can be generated by ultrafiltration and diafiltration. The exosome formulations can be suitable for administration to a human.

Abstract: The invention encompasses methods for generating stable exosome formulations and encompasses stable exosome formulations. The exosome formulations encompass stable liquid exosome formulations and stable lyophilized exosome formulations. In some embodiments, the exosome formulations can be generated by ultrafiltration and diafiltration. The exosome formulations can be suitable for administration to a human.

Abstract: The invention encompasses methods for generating exosomes comprising culturing cells in less than 20% oxygen for at least 2 days and harvesting exosomes from the cells. The invention further encompasses exosome preparations generated from cells cultured in less than 20% oxygen for at least 2 days.