Abstract: This invention relates to a broad-spectrum antimicrobial marine biologic composition for bloodstream infections, derived from smeLAL and optional hemolymph of sustainable aquaculture horseshoe crabs. The formulation serves as an injectable treatment with broad-spectrum antimicrobial activity and an array of therapeutic mechanisms. In one embodiment, subject to clinical studies and characterization of cross-species immunogenicity, the composition may act as a breakthrough antimicrobial—or as a last-resort therapy for critically ill sepsis patients. In an alternative embodiment, the biologically derived antimicrobial agent represents a viable primary therapy with advantages over synthetic antibiotics, including a rapid therapeutic window. Given unmatched efficacy, an adjuvant smeLAL immunoglobulin therapy may be warranted to allow routine use if needed to address cross-species immunogenicity.

Abstract: The present invention represents a breakthrough in addressing the global healthcare challenge of microbial infectious disease diagnosis and management. The invention employs a sustainable, modified, and enhanced protein lysate derived from horseshoe crab aquaculture that allows for rapid, sensitive, and accurate pathogen detection, typing, and determination of antimicrobial susceptibility using biological specimens regardless of opacity, e.g., whole blood. The primary embodiment is highly sensitive to clinically relevant pathogens in complex biological specimens, making it a promising tool for screening, diagnosis and treatment of bloodborne and other microbial infections. The sustainable, modified, and enhanced LAL (smeLAL) substrate and reaction chemistries can provide a cost-effective solution for detecting such pathogens using small volumes of routine hospital and laboratory specimens.

Abstract: The present invention relates to a bioactive or real-time and pathogen killing material comprised of a carbon nanostructure (preferably a fullerene but including other functionalized carbon-based nanostructures) that possess potent broad-spectrum antimicrobial properties. The present invention relates to the utilization of functionalized carbon nanostructures as a bioactive antimicrobial substance that is incorporated into a material, including a textile, fabric, solution, salve, or cream. The preferred embodiment of the present invention is fullerene derivatives that are chemically functionalized on the cage with a halogen element. The present invention pertains to a material that is suitable for barrier garments, accessory garments (shoe covers, masks, facial visors, etc.), textiles (bed sheets, blankets, towels, personal clothing, gowns, surgical drapes, curtains, drapes, pads, etc.), filtration matrices (for use in hemodialysis, hemofiltration, etc.