Abstract: We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in gliblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.

Abstract: Systems and methods facilitate sensing and tallying defecation events of subjects, such as participants in clinical trials for treatments for treating digestive diseases, such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and chronic constipation. Systems and methods may also be used by individual patients for sensing and tallying defecation events, and resulting data may be reviewed by a healthcare provider when evaluating patient gastrointestinal health and/or treatments.

Abstract: An attachment assembly for an air-moving appliance includes a diffuser attachment and a hair engagement cover. The diffuser attachment includes an inlet end configured to removably attach to the air-moving appliance. The inlet end includes an inlet for airflow to enter the diffuser attachment and the outlet end includes a diffuser surface defining discharge openings for airflow in part to expel from the diffuser attachment. The diffuser surface is curved relative to an exterior of the diffuser attachment. The hair engagement cover includes prongs arranged to extend outward from the diffuser surface when the hair engagement cover is attached to the outlet end. The attachment assembly has a first configuration in which the hair engagement cover is not attached to the diffuser surface of the diffuser attachment, and a second configuration in which the hair engagement cover is attached to the outlet end of the diffuser attachment.

Abstract: A microwell array specifically designed for culturing organoids is provided along with a system to enable automated imaging, identification, and isolation of individual organoids. The microwells of the microarray include a releasable cellraft that enables the automated release and transfer of selected organoids present on the cellrafts to a separate collection plate. Organoids grown on the microarray can be reliably tracked, imaged, and phenotypically analyzed by the instrument system in brightfield and fluorescence as they grow over time, then released and transferred fully intact for use in downstream applications. The use of the system is demonstrated using mouse hepatic and pancreatic organoids for single-organoid imaging, clonal organoid generation, parent organoid subcloning, and single-organoid RNA extraction for downstream gene expression or transcriptomic analysis.

Abstract: Disclosed herein is a pretreatment composition comprising a Group IVB metal in an amount of 200 ppm to 5.000 ppm based on total weight of the pretreatment composition, total fluoride in an amount of 1.000 ppm to 25.000 ppm based on total weight of the pretreatment composition and an electropositive metal. Also disclosed herein is a pretreatment composition comprising a Group IVB metal in an amount greater than 500 ppm based on total weight of the pretreatment composition and free fluoride in an amount of 50 ppm to 750 ppm based on total weight of the pretreatment composition, wherein the pretreatment composition has a pHI greater than 4. Also disclosed herein are systems and methods for treating a substrate. Also disclosed herein are treated substrates.

Abstract: Embodiments of the disclosure relate generally to formulations, methods, kits, and dosage forms for improved stability comprising at least two active ingredients, AMD3100, or similar stem cell mobilizer, and Tacrolimus, or FK506 derivative or analog, and one or more excipients. The formulations may be administered as a single dose subcutaneous injection. The formulations may be useful in treating various diseases, disorders or injuries.

Abstract: Isoporous block copolymers of cross-linked structures, and methods of preparing, which are resistant to harsh solvent conditions from organic, acidic or basic materials are disclosed.

Abstract: A microwell array specifically designed for culturing organoids is provided along with a system to enable automated imaging, identification, and isolation of individual organoids. The microwells of the microarray include a releasable cellraft that enables the automated release and transfer of selected organoids present on the cellrafts to a separate collection plate. Organoids grown on the microarray can be reliably tracked, imaged, and phenotypically analyzed by the instrument system in brightfield and fluorescence as they grow over time, then released and transferred fully intact for use in downstream applications. The use of the system is demonstrated using mouse hepatic and pancreatic organoids for single-organoid imaging, clonal organoid generation, parent organoid subcloning, and single-organoid RNA extraction for downstream gene expression or transcriptomic analysis.

Abstract: The disclosure relates to novel soybean plants, plant parts, and nucleotide sequences in soybean plants comprising a mutated FT1a and other genes, along with methods of using and making the same.

Abstract: An apparatus includes a crossbar to which a plurality of accessories using different mechanical interfaces may be attached and detached. The crossbar is instrumented and provides information, such as a weight change due to addition to, or removal of, items from an accessory on the crossbar. An extensible bracket attaches the crossbar to a supporting structure, decreasing mechanical strain on the crossbar due to minor misalignment of the supporting structure. Accessories such as wire hooks, shelves, bins, and so forth may be supported by the crossbar. A tether device, locking cam device, or clip device may be used to prevent lateral movement of components such as the accessories or the entire crossbar relative to its supporting structure. A baffle may be affixed to the crossbar to constrain airflow for operation in a temperature-controlled case.

Abstract: A medical appliance or prosthesis may comprise one or more layers of rotational spun nanofibers, including rotational spun polymers. The rotational spun material may comprise layers including layers of polytetrafluoroethylene (PTFE). Rotational spun nanofiber mats of certain porosities may permit tissue ingrowth into or attachment to the prosthesis. Additionally, one or more cuffs may be configured to allow tissue ingrowth to anchor the prosthesis.

Abstract: A composition comprises: a base oil; an additive; and a drug. The additive has segments which are conjugated, e.g. covalently linked, together. A first segment facilitates solubility in the base oil, whereas a second segment facilitates drug solubility and/or modifies drug release or other behaviour. The first segment may for example comprise a poly(dimethylsiloxane)-containing moiety. The second segment may for example resemble a drug molecule. The composition may for example be used as a tamponade or as a component for a tamponade administered to the eye.

Abstract: A charging station includes a charging head and a plurality of electrical connectors. The charging head is slidable along a track and rotatable along an axis. The plurality of electrical connectors is secured to the charging head and is disposed radially about the axis. Each of the electrical connectors have a different profile and are configured to engage an electrical port of an electric vehicle having a matching profile to charge the battery of the electric vehicle. The charging head is configured to slide along the track and rotate along the axis to align each of the electrical connectors with a corresponding electrical port. Each of the electrical connectors is configured to advance from and retract to the charging head to engage and disengage the corresponding electrical port.

Abstract: A composition comprises: a base oil; an additive comprising a copolymer comprising hydrophobic and hydrophilic units; and a drug. The copolymer may for example have a comb structure in which the hydrophobic units and hydrophilic units are pendant chains on a backbone of the copolymer. The hydrophobic units and hydrophilic units may for example comprise polydimethylsiloxane moieties and ethylene glycol residues respectively. The composition may for example be used as a tamponade or as a component for a tamponade administered to the eye. The invention is useful for solubilising and/or releasing drugs.

Abstract: A vehicle includes a body and a charging pad. The body defines first and second wheel wells on opposing lateral sides of the body. The body defines a cavity along a bottom surface of the body between the wheel wells and a rear end of the vehicle. The charging pad is disposed within the cavity such that the charging pad spans a distance between the first and second wheel wells. The charging pad has a secondary coil disposed therein. The secondary coil is configured to receive electrical power from a primary coil of a charging station via induction to recharge a vehicle battery.

Abstract: A charging station includes a charging head and a plurality of electrical connectors. The charging head is slidable along a track and rotatable along an axis. The plurality of electrical connectors is secured to the charging head and is disposed radially about the axis. Each of the electrical connectors have a different profile and are configured to engage an electrical port of an electric vehicle having a matching profile to charge the battery of the electric vehicle. The charging head is configured to slide along the track and rotate along the axis to align each of the electrical connectors with a corresponding electrical port. Each of the electrical connectors is configured to advance from and retract to the charging head to engage and disengage the corresponding electrical port.

Abstract: A vehicle includes a body and a charging pad. The body defines first and second wheel wells on opposing lateral sides of the body. The body defines a cavity along a bottom surface of the body between the wheel wells and a rear end of the vehicle. The charging pad is disposed within the cavity such that the charging pad spans a distance between the first and second wheel wells. The charging pad has a secondary coil disposed therein. The secondary coil is configured to receive electrical power from a primary coil of a charging station via induction to recharge a vehicle battery.

Abstract: An adapter plug for a charging port of an electric vehicle includes a housing, a first electrical connector, and a second electrical connector. The housing has circuitry disposed therein. The first electrical connector is integral to the housing, faces a first direction, and has a first profile. The first profile is configured to mate with the charging port and connect the circuitry to the charging port. The second electrical connector is integral to the housing, faces a second direction opposing the first direction, and has a second profile. The second profile matches the charging port. The second profiled is configured to mate with a connector head of a charging station and connect the circuitry to the connector head.

Abstract: A system and a computer-implemented method are disclosed. The method comprises the steps of: receiving, from a golfer mobile device, a request to conduct a round of golf, the request comprising round information and identification of a validator mobile device, receiving, from the validator mobile device, confirmation of validator status, receiving, from the golfer mobile device, score data and location data of the golfer mobile device. The method further comprises receiving, from the validator mobile device, location data of the validator mobile device, determining whether the received score data is valid by comparing the location data of the golfer mobile device to the location data of the validator mobile device, and determining and recording a score based on the score data for the golfer if the received score data is determined to be valid.

Abstract: A composition comprises: a base oil; an additive; and a drug. The additive has segments which are conjugated, e.g. covalently linked, together. A first segment facilitates solubility in the base oil, whereas a second segment facilitates drug solubility and/or modifies drug release or other behaviour. The first segment may for example comprise a poly(dimethylsiloxane)-containing moiety. The second segment may for example resemble a drug molecule. The composition may for example be used as a tamponade or as a component for a tamponade administered to the eye.