Abstract: A biopsy device includes a body, a needle, a hollow cutter, and a tissue sample holder. The needle extends distally from the body and includes a lateral aperture. The cutter is movable relative to the needle to sever a tissue sample and defines a cutter lumen. The tissue sample holder includes a manifold and an outer cover. The manifold includes a plurality of passages and an indexing portion. Each passage of the plurality of passages is configured to selectively index relative to a proximal end of the hollow cutter. The outer cover includes a resilient member. The resilient member is configured to engage with the indexing portion of the manifold to selectively index a passage of the plurality of passages with the distal end of the hollow cutter.