Patents by Inventor Radek Jorda

Radek Jorda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidines for treatment of lymphoma
    Patent number: 11186583
    Abstract: 5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidine derivatives of formula I that are effective inhibitors of kinases and exhibit strong antiproliferative and proapoptotic properties on lymphoma cells. Derivatives in the treatment of blood hyperproliferative diseases, such as Non-Hodgkin lymphomas are also disclosed.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: November 30, 2021
    Assignees: UNIVERZITA PALACKEHO V OLOMOUCI, USTAV EXPERIMENTALNI BOTANIKY AV CR, V.V.I.
    Inventors: Libor Havlicek, Antonin Sturc, Eva Reznickova, Radek Jorda, Vladimir Krystof, Miroslav Strnad
  • 2,6-disubstituted-9-cyclopentyl-9H-purines, use thereof as medicaments, and pharmaceutical compositions
    Patent number: 11028087
    Abstract: The present invention relates to novel 2,6-disubstituted-9-cyclopentyl-9H-purines of general formula I, capable of inhibiting the activity of kinases such as FLT3, CDKs and PDGFRs in cancer and other related proliferative diseases. The invention further includes pharmaceutical compositions containing the 2,6-disubstituted-9-cyclopentyl-9H-purines. Compounds of the present invention can be used as active ingredients of a pharmaceutical compositions for treating acute myeloid leukemia (AML).
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: June 8, 2021
    Assignee: UNIVERZITA PALACKEHO V OLOMOUCI
    Inventors: Tomas Gucky, Eva Reznickova, Radek Jorda, Vladimir Krystof, Miroslav Strnad, Tereza Radosova Muchova, Vladimir Divoky
  • 5-ALKYLTHIO-7-[(4-ARYLBENZYL)AMINO]-1(2)H-PYRAZOLO[4,3-D]PYRIMIDINES FOR TREATMENT OF LYMPHOMA
    Publication number: 20200361943
    Abstract: 5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidine derivatives of formula I that are effective inhibitors of kinases and exhibit strong antiproliferative and proapoptotic properties on lymphoma cells. Derivatives in the treatment of blood hyperproliferative diseases, such as Non-Hodgkin lymphomas are also disclosed.
    Type: Application
    Filed: February 1, 2019
    Publication date: November 19, 2020
    Applicants: UNIVERZITA PALACKEHO V OLOMOUCI, USTAV EXPERIMENTALNI BOTANIKY AV CR, V.V.I.
    Inventors: Libor HAVLICEK, Antonin STURC, Eva REZNICKOVA, Radek JORDA, Vladimir KRYSTOF, Miroslav STRNAD
  • 2,6-DISUBSTITUTED-9-CYCLOPENTYL-9H-PURINES, USE THEREOF AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS
    Publication number: 20200087306
    Abstract: The present invention relates to novel 2,6-disubstituted-9-cyclopentyl-9H-purines of general formula I, capable of inhibiting the activity of kinases such as FLT3, CDKs and PDGFRs in cancer and other related proliferative diseases. The invention further includes pharmaceutical compositions containing the 2,6-disubstituted-9-cyclopentyl-9H-purines. Compounds of the present invention can be used as active ingredients of a pharmaceutical compositions for treating acute myeloid leukemia (AML).
    Type: Application
    Filed: March 19, 2018
    Publication date: March 19, 2020
    Applicant: UNIVERZITA PALACKEHO V OLOMOUCI
    Inventors: TOMAS GUCKY, Eva REZNICKOVA, Radek JORDA, Vladimir KRYSTOF, Miroslav STRNAD, Tereza RADOSOVA MUCHOVA, Vladimir DIVOKY
  • 5-substituted 7- [4-(2-pyridyl)phenylmethylamino] -3-isopropylpyrazolo4,3-D]pyrimidine derivatives, use thereof as medicaments, and pharmaceutical compositions
    Patent number: 9957273
    Abstract: 5-substituted-7-[4-(2-pyridyl)phenylmethylamino]-3-isopropylpyrazolo[4,3-d]pyrimidines are potent inhibitors of protein kinases, especially cyclin-dependent kinases such as CDK2 and CDK5, and display antileukemic, pro-apoptotic, antiangiogenic and anticancer activities. The invention also relates to processes for their preparation, to pharmaceutical compositions and to their use as medicaments, particularly in the treatment of disorders involving cell proliferation, apoptosis, angiogenesis and inflammation, such as leukemia and metastatic solid cancer.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: May 1, 2018
    Assignee: USTAV EXPERIMENTALNI BOTANIKY AV CR, V.V.I.
    Inventors: Libor Havlicek, Antonin Sturc, Vladimir Krystof, Radek Jorda, Tomas Pospisil, Stefan Zahler, Angelika Vollmar, Miroslav Strnad
  • 5-SUBSTITUTED 7-[4-(2-PYRIDYL)PHENYLMETHYLAMINO]-3-ISOPROPYLPYRAZOLO4,3-D]PYRIMIDINE DERIVATIVES, USE THEREOF AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS
    Publication number: 20180072736
    Abstract: 5-substituted-7-[4-(2-pyridyl)phenylmethylamino]-3-isopropylpyrazolo[4,3-d]pyrimidines are potent inhibitors of protein kinases, especially cyclin-dependent kinases such as CDK2 and CDK5, and display antileukemic, pro-apoptotic, antiangiogenic and anticancer activities. The invention also relates to processes for their preparation, to pharmaceutical compositions and to their use as medicaments, particularly in the treatment of disorders involving cell proliferation, apoptosis, angiogenesis and inflammation, such as leukemia and metastatic solid cancer.
    Type: Application
    Filed: October 2, 2015
    Publication date: March 15, 2018
    Applicant: USTAV EXPERIMENTALNI BOTANIKY AV CR, V.V.I.
    Inventors: Libor HAVLICEK, Antonin STURC, Vladimir KRYSTOF, Radek JORDA, Tomas POSPISIL, Stefan ZAHLER, Angelika VOLLMAR, Miroslav STRNAD
  • 2-SUBSTITUTED-6-BIARYLMETHYLAMINO-9-CYCLOPENTYL-9H-PURINE DERIVATIVES, USE THEREOF AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS
    Publication number: 20150368248
    Abstract: This invention relates to novel 2-substituted-6-biarylmethylamino-9-cyclopentyl-9H-purine derivatives, showing activity as specific inhibitors of growth and angiogenesis of hepatocellular carcinoma. The invention further includes pharmaceutical compositions containing the 2-substituted-6-biarylmethylamino-9-cyclopentylpurines.
    Type: Application
    Filed: February 5, 2014
    Publication date: December 24, 2015
    Applicants: BIOPATTERNS S.R.O., UNIVERZITA PALACKEHO V OLOMOUCI
    Inventors: Tomas GUCKY, Radek JORDA, Marek ZATLOUKAL, Vladimir KRYSTOF, Lucie RAROVA, Eva REZNICKOVA, Wolfgang MIKULITS, Miroslav STRNAD
  • Substituted 6-(2-hydroxybenzylamino)purine derivatives, their use as medicaments and compositions containing these derivatives
    Patent number: 8492391
    Abstract: The invention relates to substituted 6-(2-hydroxybenzylamino)purines of general formula I, to their activity as cyclin-dependent kinases 2, 5, 7 and 9 inhibitors and to their use as medicaments, particularly in the treatment of disorders involving cell proliferation or inflammation. The invention further includes pharmaceutical compositions containing the substituted 6-(2-hydroxybenzylamino)purines.
    Type: Grant
    Filed: June 2, 2010
    Date of Patent: July 23, 2013
    Assignees: Univerzita Palackeho V Olomouci, Biopatterns, S.R.O.
    Inventors: Marek Zatloukal, Vladimir Krystof, Libor Havlicek, Igor Popa, Karel Dolezal, Miroslav Strnad, Radek Jorda
  • Substituted 6-(2-hydroxybenzylamino)purine Derivatives, Their Use as Medicaments and Compositions Containing These Derivatives
    Publication number: 20120070512
    Abstract: The invention relates to substituted 6-(2-hydroxybenzylamino)purines of general formula I, to their activity as cyclin-dependent kinases 2, 5, 7 and 9 inhibitors and to their use as medicaments, particularly in the treatment of disorders involving cell proliferation or inflammation. The invention further includes pharmaceutical compositions containing the substituted 6-(2-hydroxybenzylamino)purines.
    Type: Application
    Filed: June 2, 2010
    Publication date: March 22, 2012
    Inventors: Marek Zatloukal, Vladimir Krystof, Libor Havlicek, Igor Popa, Karel Dolezal, Miroslav Strnad, Radek Jorda