Patents by Inventor Radek Melnicky

Radek Melnicky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline forms of zinc trisodium pentetic acid
    Patent number: 9447120
    Abstract: The invention relates to the production of zinc trisodium pentetic acid (Zn-DTPA) and to new crystalline forms of said salt.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: September 20, 2016
    Assignee: Hameln Pharma Plus GmbH
    Inventors: Christian Schickaneder, Vendel Smahovský, Pavol Valachovic, Mathias Dewald, Pavel Hradil, Janka Králová, Radek Melnický, Petr Slézar, Ivan Kakalik
  • Method for preparing 4-[3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]-benzoic acid
    Patent number: 8129421
    Abstract: A method for preparing 4-[3,5-bis(2-hydroxyphenyl )-[1,2,4]triazol-1-yl]benzoic acid of formula (I) by reaction of 2-(2-hydroxyphenyl)benz[e][1,3]oxazin-4-one of formula (II) with 4-hydrazinobenzoic acid of formula (III) in an organic acid or in a mixture of an organic acid and an organic solvent.
    Type: Grant
    Filed: June 16, 2008
    Date of Patent: March 6, 2012
    Assignee: Farmak, A S
    Inventors: Radek Melnicky, Pavel Hradil, Lubomir Kvapil, Martin Grepl, Petr Slezar
  • Methods for the preparation of salts of 2-[2-(4-dibenzo[B,F][1,4]thiazepin-11-yl-1-piperazinyl)ethoxyl]ethanol (quetiapine) and for the purification thereof
    Patent number: 8034805
    Abstract: A method for the preparation of salts of 2-[2-(4-dibenzo[b,fj[1,4]thiazepin-11-yl-1 -piperazinyl)ethoxy]ethanol (quetiapine) from the quetiapine base and the respective acid, wherein the salt is precipitated from a mixture of solvents, the mixture being either a mixture of an aromatic hydrocarbon and a ketone or ester, or that of an aromatic hydrocarbon, water and a ketone or ester. The salts of quetiapine are purified by partial crystallization, wherein only a part of the salt of quetiapine is dissolved in a C1 to C6 alcohol used.
    Type: Grant
    Filed: August 31, 2006
    Date of Patent: October 11, 2011
    Assignee: Farmak, A.S.
    Inventors: Pavel Hradil, Lubomir Kvapil, Roman Gabriel, Martin Grepl, Jan Novotny, Petr Slezar, Radek Melnicky
  • METHOD FOR PREPARING 4-[3,5-BIS(2-HYDROXYPHENYL)-[1,2,4]TRIAZOL-1-YL]-BENZOIC ACID
    Publication number: 20110034702
    Abstract: A method for preparing 4-[3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]benzoic acid of formula (I) by reaction of 2-(2-hydroxyphenyl)benz[e][1,3]oxazin-4-one of formula (II) with 4-hydrazinobenzoic acid of formula (III) in an organic acid or in a mixture of an organic acid and an organic solvent.
    Type: Application
    Filed: June 16, 2008
    Publication date: February 10, 2011
    Inventors: Radek Melnicky, Pavel Hradil, Lubomir Kvapil, Martin Grepl, Petr Slezar
  • METHODS FOR THE PREPARATION OF SALTS OF 2-[2-(4-DIBENZO[B,F][1,4]THIAZEPIN-11-YL-1-PIPERAZINYL)ETHOXYL]ETHANOL (QUETIAPINE) AND FOR THE PURIFICATION THEREOF
    Publication number: 20090275747
    Abstract: A method for the preparation of salts of 2-[2-(4-dibenzo[b,fj[1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol (quetiapine) from the quetiapine base and the respective acid, wherein the salt is precipitated from a mixture of solvents, the mixture being either a mixture of an aromatic hydrocarbon and a ketone or ester, or that of an aromatic hydrocarbon, water and a ketone or ester. The salts of quetiapine are purified by partial crystallization, wherein only a part of the salt of quetiapine is dissolved in a C1 to C6 alcohol used.
    Type: Application
    Filed: August 31, 2006
    Publication date: November 5, 2009
    Inventors: Pavel Hradil, Lubomir Kvapil, Roman Gabriel, Martin Grepl, Jan Novotny, Petr Slezar, Radek Melnicky