Patents by Inventor Radek SPÍSEK

Radek SPÍSEK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PATIENT SELECTION FOR TREATMENT WITH DENDRITIC CELL VACCINATION
    Publication number: 20240131060
    Abstract: The invention relates to a dendritic cell (DC) vaccine for use in a method of treating cancer in a patient, wherein the patient is selected for treatment with said DC vaccine. The selection inter alia comprises determining in a tumor sample from the patient the amount of CD8+ T-cells and/or the tumor mutation burden (TMB) and comparing the determined amount to a predetermined threshold level. The selection allows identifying patients that particularly benefit from DC treatment.
    Type: Application
    Filed: February 11, 2022
    Publication date: April 25, 2024
    Inventors: Jitka PALICH FUCIKOVA, Radek SPISEK
  • IMMUNOTHERAPY FOR CANCER
    Publication number: 20210252120
    Abstract: Disclosed is a composition comprising an immunogenic composition for use in treatment of squamous cell carcinoma in combination with myeloid-derived suppressor cell-inhibiting agents as well as a corresponding method of treatment.
    Type: Application
    Filed: January 4, 2021
    Publication date: August 19, 2021
    Inventors: Irena ADKINS, Nada PODZIMKOVÁ, Ondrej PALATA, Radek SPISEK
  • DENDRITIC CELL VACCINATION SEQUENTIAL TO CHEMOTHERAPY
    Publication number: 20210060145
    Abstract: The present invention relates to the use of a dendritic cell vaccination sequential to chemotherapy, wherein the dendritic cell vaccine is administered to a patient after completion of chemotherapy with at least one chemotherapeutic agent.
    Type: Application
    Filed: January 25, 2019
    Publication date: March 4, 2021
    Inventors: Radek Spisek, Jirina Bartunkova
  • DENDRITIC CELL VACCINATION IN PARALLEL TO CHEMOTHERAPY
    Publication number: 20210060146
    Abstract: The present invention relates to a dendritic cell vaccine for use in the treatment of cancer, wherein the dendritic cell vaccine is administered to a patient in parallel to chemotherapy with at least one chemotherapeutic agent.
    Type: Application
    Filed: January 25, 2019
    Publication date: March 4, 2021
    Inventors: Radek Spisek, Jirina Bartunkova
  • CRYOPRESERVATION OF APOPTOTIC CANCER CELLS FOR USE IN IMMUNOTHERAPY AGAINST CANCER
    Publication number: 20200147191
    Abstract: Described herein is a reliable method for preparing a potent vaccine useful for immunotherapy comprising the step of cryopreserving a population of cells undergoing immunogenic cell death, and using such cells to activate dendritic cells for use in immunotherapy. In a specific embodiment, the method comprises cryopreserving cancer cells undergoing cell death, which can be used to prepare a pharmaceutical composition for immunotherapy against cancer.
    Type: Application
    Filed: December 30, 2019
    Publication date: May 14, 2020
    Inventors: Jitka Fucikova, Lenka Koci, Katerina Pokorna, Iva Truxova, Irena Moserova, Daniela Rozkova, Radek Spisek
  • Cryopreservation of apoptotic cancer cells for use in immunotherapy against cancer
    Patent number: 10561717
    Abstract: Described herein is a reliable method for preparing a potent vaccine useful for immunotherapy comprising the step of cryopreserving a population of cells undergoing immunogenic cell death, and using such cells to activate dendritic cells for use in immunotherapy. In a specific embodiment, the method comprises cryopreserving cancer cells undergoing cell death, which can be used to prepare a pharmaceutical composition for immunotherapy against cancer.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: February 18, 2020
    Assignee: SOTIO a.s.
    Inventors: Jitka Fucikova, Lenka Koci, Katerina Pokorna, Iva Truxova, Irena Moserova, Daniela Rozkova, Radek Spisek
  • MEANS AND METHODS FOR ACTIVE CELLULAR IMMUNOTHERAPY OF CANCER BY USING TUMOR CELLS KILLED BY HIGH HYDROSTATIC PRESSURE AND DENDRITIC CELLS
    Publication number: 20190216909
    Abstract: Disclosed are pharmaceutical compositions for inducing an immune response against tumor cells comprising tumor cells which are made apoptotic by treatment with high hydrostatic pressure and dendritic cells, and methods for producing such compositions.
    Type: Application
    Filed: March 26, 2019
    Publication date: July 18, 2019
    Inventors: Jirina BARTÛNKOVÁ, Radek SPÍSEK
  • IMMUNOTHERAPY FOR CANCER
    Publication number: 20190125850
    Abstract: Disclosed is a composition comprising an immunogenic composition for use in treatment of squamous cell carcinoma in combination with myeloid-derived suppressor cell-inhibiting agents as well as a corresponding method of treatment.
    Type: Application
    Filed: June 6, 2017
    Publication date: May 2, 2019
    Inventors: Irena ADKINS, Nada HRADILOVÁ, Ondrej PALATA, Radek SPISEK
  • CRYOPRESERVATION OF APOPTOTIC CANCER CELLS FOR USE IN IMMUNOTHERAPY AGAINST CANCER
    Publication number: 20190070278
    Abstract: Described herein is a reliable method for preparing a potent vaccine useful for immunotherapy comprising the step of cryopreserving a population of cells undergoing immunogenic cell death, and using such cells to activate dendritic cells for use in immunotherapy. In a specific embodiment, the method comprises cryopreserving cancer cells undergoing cell death, which can be used to prepare a pharmaceutical composition for immunotherapy against cancer.
    Type: Application
    Filed: November 2, 2018
    Publication date: March 7, 2019
    Inventors: Jitka Fucikova, Lenka Koci, Katerina Pokorna, Iva Truxova, Irena Moserova, Daniela Rozkova, Radek Spisek
  • TOLEROGENIC DENDRITIC CELLS, METHODS OF PRODUCING THE SAME, AND USES THEREOF
    Publication number: 20180360876
    Abstract: Described herein are methods for the preparation of stable semi-mature tolerogenic dendritic cells and compositions comprising such stable semi-mature tolerogenic dendritic cells. The stable semi-mature tolerogenic dendritic cells described herein and compositions thereof can be used for the establishment of immune tolerance when treating an autoimmune disease, graft rejection and/or graft-versus-host disease.
    Type: Application
    Filed: May 10, 2018
    Publication date: December 20, 2018
    Inventors: Lenka PALOVÁ JELÍNKOVÁ, Klára DÁÑOVÁ, Radek SPÍSEK
  • Cryopreservation of apoptotic cancer cells for use in immunotherapy against cancer
    Patent number: 10155033
    Abstract: Described herein is a reliable method for preparing a potent vaccine useful for immunotherapy comprising the step of cryopreserving a population of cells undergoing immunogenic cell death, and using such cells to activate dendritic cells for use in immunotherapy. In a specific embodiment, the method comprises cryopreserving cancer cells undergoing cell death, which can be used to prepare a pharmaceutical composition for immunotherapy against cancer.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: December 18, 2018
    Assignee: SOTIO A.S.
    Inventors: Jitka Fucikova, Lenka Koci, Katerina Pokorna, Iva Truxova, Irena Moserova, Daniela Rozkova, Radek Spisek
  • CRYOPRESERVATION OF APOPTOTIC CANCER CELLS FOR USE IN IMMUNOTHERAPY AGAINST CANCER
    Publication number: 20180125956
    Abstract: Described herein is a reliable method for preparing a potent vaccine useful for immunotherapy comprising the step of cryopreserving a population of cells undergoing immunogenic cell death, and using such cells to activate dendritic cells for use in immunotherapy. In a specific embodiment, the method comprises cryopreserving cancer cells undergoing cell death, which can be used to prepare a pharmaceutical composition for immunotherapy against cancer.
    Type: Application
    Filed: January 10, 2018
    Publication date: May 10, 2018
    Inventors: Jitka Fucikova, Lenka Koci, Katerina Pokorna, Iva Truxova, Irena Moserova, Daniela Rozkova, Radek Spisek
  • Cryopreservation of apoptotic cancer cells for use in immunotherapy against cancer
    Patent number: 9895430
    Abstract: Described herein is a reliable method for preparing a potent vaccine useful for immunotherapy comprising the step of cryopreserving a population of cells undergoing immunogenic cell death, and using such cells to activate dendritic cells for use in immunotherapy. In a specific embodiment, the method comprises cryopreserving cancer cells undergoing cell death, which can be used to prepare a pharmaceutical composition for immunotherapy against cancer.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: February 20, 2018
    Assignee: SOTIO A.S.
    Inventors: Jitka Fucikova, Lenka Koci, Katerina Pokorna, Iva Truxova, Irena Moserova, Daniela Rozkova, Radek Spisek
  • TOLEROGENIC DENDRITIC CELLS, METHODS OF PRODUCING THE SAME, AND USES THEREOF
    Publication number: 20170340669
    Abstract: Described herein are methods for the preparation of stable semi-mature tolerogenic dendritic cells and compositions comprising such stable semi-mature tolerogenic dendritic cells. The stable semi-mature tolerogenic dendritic cells described herein and compositions thereof can be used for the establishment of immune tolerance when treating an autoimmune disease, graft rejection and/or graft-versus-host disease.
    Type: Application
    Filed: October 22, 2015
    Publication date: November 30, 2017
    Inventors: Lenka PALOVÁ JELÍNKOVÁ, Klára DÁÑOVÁ, Radek SPÍSEK
  • CRYOPRESERVATION OF APOPTOTIC CANCER CELLS FOR USE IN IMMUNOTHERAPY AGAINST CANCER
    Publication number: 20170232086
    Abstract: Described herein is a reliable method for preparing a potent vaccine useful for immunotherapy comprising the step of cryopreserving a population of cells undergoing immunogenic cell death, and using such cells to activate dendritic cells for use in immunotherapy. In a specific embodiment, the method comprises cryopreserving cancer cells undergoing cell death, which can be used to prepare a pharmaceutical composition for immunotherapy against cancer.
    Type: Application
    Filed: December 22, 2016
    Publication date: August 17, 2017
    Inventors: Jitka Fucikova, Lenka Koci, Katerina Pokorna, Iva Truxova, Irena Moserova, Daniela Rozkova, Radek Spisek
  • Cryopreservation of apoptotic cancer cells for use in immunotherapy against cancer
    Patent number: 9562219
    Abstract: Described herein is a reliable method for preparing a potent vaccine useful for immunotherapy comprising the step of cryopreserving a population of cells undergoing immunogenic cell death, and using such cells to activate dendritic cells for use in immunotherapy. In a specific embodiment, the method comprises cryopreserving cancer cells undergoing cell death, which can be used to prepare a pharmaceutical composition for immunotherapy against cancer.
    Type: Grant
    Filed: December 27, 2013
    Date of Patent: February 7, 2017
    Assignee: SOTIO A.S.
    Inventors: Jitka Fucikova, Lenka Koci, Katerina Pokorna, Iva Truxova, Irena Moserova, Daniela Rozkova, Radek Spisek
  • IN VITRO METHOD FOR THE DIAGNOSIS AND SURVEILLANCE OF CANCER
    Publication number: 20150337384
    Abstract: The present invention relates to an in vitro method for the diagnosis and/or the monitoring and/or predicting the progress of a cancer disease, characterized in that in at least one sample the ratio of Tregs-cells to at least one other group of T cells comprising the group of Th17 cells, Th1 cells and/or Th2 cells is determined.
    Type: Application
    Filed: June 27, 2013
    Publication date: November 26, 2015
    Applicant: SOTIO a.s.
    Inventors: Jirina BARTUNKOVÁ, Radek SPÍSEK
  • CRYOPRESERVATION OF APOPTOTIC CANCER CELLS FOR USE IN IMMUNOTHERAPY AGAINST CANCER
    Publication number: 20150184130
    Abstract: Described herein is a reliable method for preparing a potent vaccine useful for immunotherapy comprising the step of cryopreserving a population of cells undergoing immunogenic cell death, and using such cells to activate dendritic cells for use in immunotherapy. In a specific embodiment, the method comprises cryopreserving cancer cells undergoing cell death, which can be used to prepare a pharmaceutical composition for immunotherapy against cancer.
    Type: Application
    Filed: December 27, 2013
    Publication date: July 2, 2015
    Applicant: SOTIO a.s.
    Inventors: Jitka Fucikova, Lenka Koci, Katerina Pokorna, Iva Truxova, Irena Moserova, Daniela Rozkova, Radek Spisek
  • MEANS AND METHODS FOR ACTIVE CELLULAR IMMUNOTHERAPY OF CANCER BY USING TUMOR CELLS KILLED BY HIGH HYDROSTATIC PRESSURE AND DENDRITIC CELLS
    Publication number: 20140086957
    Abstract: Disclosed are pharmaceutical compositions for inducing an immune response against tumor cells comprising tumor cells which are made apoptotic by treatment with high hydrostatic pressure and dendritic cells, and methods for producing such compositions.
    Type: Application
    Filed: July 4, 2012
    Publication date: March 27, 2014
    Applicant: SOTIO a.s.
    Inventors: Jirina Bartunková, Radek Spisek
  • Means And Methods For Active Cellular Immunotherapy Of Cancer By Using Tumor Cells Killed By High Hydrostatic Pressure and Dendritic Cells
    Publication number: 20130011438
    Abstract: Disclosed are pharmaceutical compositions for inducing an immune response against tumor cells comprising tumor cells which are made apoptotic by treatment with high hydrostatic pressure and dendritic cells, and methods for producing such compositions.
    Type: Application
    Filed: July 4, 2012
    Publication date: January 10, 2013
    Applicant: SOTIO a.s.
    Inventors: Jirina BARTUNKOVÁ, Radek SPÍSEK