Patents by Inventor Radha Munagala

Radha Munagala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Exosome-Mediated Transfection for Delivery of Nucleic Acids
    Publication number: 20220347109
    Abstract: The present development is a transfection reagent prepared by ionic interaction of colostrum powder-derived exosomes and a polycation. The resulting exosome-polycation matrix, or EPM, is entrapped with biologic materials, such as siRNA, mRNA, antisense oligo or plasmid DNA or a plasmid DNA expression construct.
    Type: Application
    Filed: January 27, 2020
    Publication date: November 3, 2022
    Inventors: RAMESH C. GUPTA, RADHA MUNAGALA, JEYAPRAKASH JEYABALAN, RENA MARGARET WALLEN, WENDY A. SPENCER, FARRUKH AQIL
  • Milk-Derived Microvesicle Compositions and Related Methods
    Publication number: 20190374467
    Abstract: A composition is provided that comprises a therapeutic agent encapsulated by a milk-derived microvesicle. The compositions can include therapeutic agents such as phytochemical agents or chemotherapeutic agents, while the milk-derived microvesicle can be derived from raw milk or colostrum. Further provided are methods for isolating a microvesicle that includes the steps of obtaining an amount of milk, and subjecting the milk to a series of sequential centrifugations configured to yield greater than about 300 mg of microvesicle protein per 100 ml of milk. Methods of modifying an immune response and treating a cancer in which a milk-derived microvesicle composition is administered are also provided.
    Type: Application
    Filed: August 5, 2019
    Publication date: December 12, 2019
    Inventors: Ramesh C. Gupta, Radha Munagala, Farrukh Aqil, Jeyaprakash Jeyabalan
  • Milk-derived microvesicle compositions and related methods
    Patent number: 10420723
    Abstract: A composition is provided that comprises a therapeutic agent encapsulated by a milk-derived microvesicle. The compositions can include therapeutic agents such as phytochemical agents or chemotherapeutic agents, while the milk-derived microvesicle can be derived from raw milk or colostrum. Further provided are methods for isolating a microvesicle that includes the steps of obtaining an amount of milk, and subjecting the milk to a series of sequential centrifugations configured to yield greater than about 300 mg of microvesicle protein per 100 ml of milk. Methods of modifying an immune response and treating a cancer in which a milk-derived microvesicle composition is administered are also provided.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: September 24, 2019
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Ramesh C. Gupta, Radha Munagala, Farrukh Aqil, Jeyaprakash Jeyabalan
  • Milk-Derived Microvesicle Compositions and Related Methods
    Publication number: 20180185285
    Abstract: A composition is provided that comprises a therapeutic agent encapsulated by a milk-derived microvesicle. The compositions can include therapeutic agents such as phytochemical agents or chemotherapeutic agents, while the milk-derived microvesicle can be derived from raw milk or colostrum. Further provided are methods for isolating a microvesicle that includes the steps of obtaining an amount of milk, and subjecting the milk to a series of sequential centrifugations configured to yield greater than about 300 mg of microvesicle protein per 100 ml of milk. Methods of modifying an immune response and treating a cancer in which a milk-derived microvesicle composition is administered are also provided.
    Type: Application
    Filed: March 2, 2018
    Publication date: July 5, 2018
    Inventors: Ramesh C. Gupta, Radha Munagala, Farrukh Aqil, Jeyaprakash Jeyabalan
  • Milk-derived microvesicle compositions and related methods
    Patent number: 9943482
    Abstract: A composition is provided that comprises a therapeutic agent encapsulated by a milk-derived microvesicle. The compositions can include therapeutic agents such as phytochemical agents or chemotherapeutic agents, while the milk-derived microvesicle can be derived from raw milk or colostrum. Further provided are methods for isolating a microvesicle that includes the steps of obtaining an amount of milk, and subjecting the milk to a series of sequential centrifugations configured to yield greater than about 300 mg of microvesicle protein per 100 ml of milk. Methods of modifying an immune response and treating a cancer in which a milk-derived microvesicle composition is administered are also provided.
    Type: Grant
    Filed: February 26, 2014
    Date of Patent: April 17, 2018
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Ramesh C. Gupta, Radha Munagala, Farrukh Aqil, Jeyaprakash Jeyabalan
  • MILK-DERIVED MICROVESICLE COMPOSITIONS AND RELATED METHODS
    Publication number: 20160000710
    Abstract: A composition is provided that comprises a therapeutic agent encapsulated by a milk-derived microvesicle. The compositions can include therapeutic agents such as phytochemical agents or chemotherapeutic agents, while the milk-derived microvesicle can be derived from raw milk or colostrum. Further provided are methods for isolating a microvesicle that includes the steps of obtaining an amount of milk, and subjecting the milk to a series of sequential centrifugations configured to yield greater than about 300 mg of microvesicle protein per 100 ml of milk. Methods of modifying an immune response and treating a cancer in which a milk-derived microvesicle composition is administered are also provided.
    Type: Application
    Filed: February 26, 2014
    Publication date: January 7, 2016
    Inventors: Ramesh C. Gupta, Radha Munagala, Farrukh Aqil, Jeyaprakash Jeyabalan