Abstract: Compositions and methods for treating a glomerular disorder. Compositions and methods comprise a cytochrome P450 inhibitor. Preferred inhibitors inhibit a cytochrome P450 2B family member. Compositions and methods reduce proteinuria associated with a glomerular disorder, such as, minimal change nephrotic syndrome.

Abstract: Compositions and methods for chemotherapy are disclosed. The compositions and methods disclose herein are effective inhibitors of chemotherapy-induced nephrotoxicity, yet unexpectedly do not inhibit the antineoplastic activity of the chemotherapeutic compound. The chemotherapeutic compositions and methods of the invention comprise an inhibitor of catalytic iron. In a preferred embodiment, the inhibitor is a cytochrome P450 inhibitor and the chemotherapeutic compound is cisplatin.