Patents by Inventor Radhakrishnan P. Iyer

Radhakrishnan P. Iyer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190292215
    Abstract: Disclosed are compounds and compositions for the induction of expression of a pattern recognition receptor (e.g., STING) and methods of use thereof.
    Type: Application
    Filed: July 14, 2017
    Publication date: September 26, 2019
    Inventors: Radhakrishnan P. Iyer, Seetharamaiyer Padmanabhan, Dillon Cleary, Geeta Meher, Rayomand H. Gimi, Anjaneyulu Sheri, Shenghua Zhou, Sreerupa Challa
  • Publication number: 20190290673
    Abstract: This invention relates to methods useful in the treatment of a hepatitis infection.
    Type: Application
    Filed: October 24, 2017
    Publication date: September 26, 2019
    Inventors: Radhakrishnan P. Iyer, Rayomand H. Gimi
  • Publication number: 20190262372
    Abstract: Disclosed are compounds and compositions for the activation or induction of expression of a pattern recognition receptor (e.g., STING, RIG-I, MDA5), and methods of use thereof.
    Type: Application
    Filed: July 6, 2017
    Publication date: August 29, 2019
    Inventors: Radhakrishnan P. Iyer, Anjaneyulu Sheri, Seetharamaiyer Padmanabhan, Geeta Meher, Shenghua Zhou, Sreerupa Challa, Rayomand H. Gimi, Dillon Cleary
  • Patent number: 10391166
    Abstract: The invention provides a method of treating a microbial infection in a subject and a method of improving an immune system response in a subject against a disease, condition, infection, or virus thereof, by administering an effective amount of a nucleoside, short oligonucleotide compound or an analog thereof, or a pharmaceutically acceptable salt, racemate, enantiomer, diastereomer, geometric isomer, or tautomer thereof. In addition, the invention provides methods for treating or preventing a viral infection, bacterial infection, parasitic infection, or fungal infection in a subject (such as, a human). The compounds of the invention include, for example, di-, and trinucleotide compounds as provided herein. The compounds of the invention are useful for different therapeutic applications including, such as, prophylactics and therapeutics. The invention also provides design and synthesis of a compound that is useful for various therapeutic applications as mentioned herein.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: August 27, 2019
    Assignee: SPRING BREAK PHARMACEUTICALS, INC.
    Inventor: Radhakrishnan P. Iyer
  • Patent number: 10376533
    Abstract: The present invention provides compositions methods for treating susceptible viral infections, especially hepatitis C viral (HCV) infections as well as co infections of HCV with other viruses such as HBV and/or HIV. In one embodiment, the present invention provides compositions having the formula (I) and their use in treating viral infections: or a pharmaceutically acceptable salt, ester, stereoisomer, tautomers, solvate, prodrug, or combination thereof.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: August 13, 2019
    Assignee: Spring Bank Pharmaceuticals, Inc.
    Inventors: Radhakrishnan P. Iyer, Seetharamaiyer Padmanabhan
  • Patent number: 10344046
    Abstract: The present invention discloses compounds of formula (I): which exhibit antiviral properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of anti-HBV treatment. The invention also relates to methods of treating a HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: July 9, 2019
    Assignee: Spring Bank Pharmaceuticals, Inc.
    Inventors: Radhakrishnan P. Iyer, Seetharamaiyer Padmanabhan
  • Publication number: 20190070212
    Abstract: This invention relates to compounds and compositions for use in the treatment of microbial infections, e.g., HCV, HBV, and RSV.
    Type: Application
    Filed: March 10, 2017
    Publication date: March 7, 2019
    Inventor: Radhakrishnan P. Iyer
  • Publication number: 20190046552
    Abstract: In one aspect, the present invention features a method of treating a subject infected with the Hepatitis C virus, the method comprising administering to the subject a pharmaceutical composition comprising a compound of Formula (I) at a dosage of about 10 mg to about 1500 mg, wherein the compound is selected from Formula Ia, Formula Ib, and Formula Ic, or a prodrug or pharmaceutically acceptable salt thereof to thereby treat the subject. In another aspect, the present invention features a kit comprising a pharmaceutical composition comprising the compound of Formula (I). In some embodiments, the kit further comprises an additional agent or treatment.
    Type: Application
    Filed: April 7, 2016
    Publication date: February 14, 2019
    Inventor: Radhakrishnan P. Iyer
  • Publication number: 20180273574
    Abstract: The present invention discloses compounds of formula (I): which exhibit antiviral properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of anti-HBV treatment. The invention also relates to methods of treating a HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
    Type: Application
    Filed: March 15, 2018
    Publication date: September 27, 2018
    Inventors: Radhakrishnan P. Iyer, Seetharamaiyer Padmanabhan
  • Patent number: 10047114
    Abstract: The present invention discloses compounds of formula (I): which exhibit antiviral properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of anti-HBV treatment. The invention also relates to methods of treating a HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: August 14, 2018
    Assignee: Spring Bank Pharmaceuticals, Inc.
    Inventors: Radhakrishnan P. Iyer, Seetharamaiyer Padmanabhan
  • Publication number: 20180185404
    Abstract: This invention relates to compositions and methods for the treatment of infection such as RSV, influenza, adenovirus, or rhinovirus.
    Type: Application
    Filed: July 1, 2016
    Publication date: July 5, 2018
    Inventors: Radhakrishnan P. IYER, Seetharamaiyer PADMANABHAN
  • Publication number: 20180110796
    Abstract: This invention relates to methods useful in the treatment of a hepatitis infection.
    Type: Application
    Filed: April 7, 2016
    Publication date: April 26, 2018
    Inventor: Radhakrishnan P. Iyer
  • Publication number: 20170304344
    Abstract: The present invention provides compositions methods for treating susceptible viral infections, especially hepatitis C viral (HCV) infections as well as co infections of HCV with other viruses such as HBV and/or HIV. In one embodiment, the present invention provides compositions having the formula (I) and their use in treating viral infections: or a pharmaceutically acceptable salt, ester, stereoisomer, tautomers, solvate, prodrug, or combination thereof.
    Type: Application
    Filed: December 2, 2016
    Publication date: October 26, 2017
    Inventors: Radhakrishnan P. Iyer, Seetharamaiyer Padmanabhan
  • Patent number: 9539276
    Abstract: The present invention provides compositions methods for treating susceptible viral infections, especially hepatitis C viral (HCV) infections as well as co infections of HCV with other viruses such as HBV and/or HIV. In one embodiment, the present invention provides compositions having the formula (I) and their use in treating viral infections: or a pharmaceutically acceptable salt, ester, stereoisomer, tautomers, solvate, prodrug, or combination thereof.
    Type: Grant
    Filed: August 11, 2015
    Date of Patent: January 10, 2017
    Assignee: SPRING BANK PHARMACEUTICALS, INC.
    Inventors: Radhakrishnan P. Iyer, Seetharamaiyer Padmanabhan
  • Publication number: 20160060287
    Abstract: The present invention discloses compounds of formula (I): which exhibit antiviral properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of anti-HBV treatment. The invention also relates to methods of treating a HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
    Type: Application
    Filed: November 12, 2015
    Publication date: March 3, 2016
    Inventors: Radhakrishnan P. Iyer, Seetharamaiyer Padmanabhan
  • Publication number: 20160038527
    Abstract: The present invention provides compositions methods for treating susceptible viral infections, especially hepatitis C viral (HCV) infections as well as co infections of HCV with other viruses such as HBV and/or HIV. In one embodiment, the present invention provides compositions having the formula (I) and their use in treating viral infections: or a pharmaceutically acceptable salt, ester, stereoisomer, tautomers, solvate, prodrug, or combination thereof.
    Type: Application
    Filed: August 11, 2015
    Publication date: February 11, 2016
    Inventors: Radhakrishnan P. Iyer, Seetharamaiyer Padmanabhan
  • Publication number: 20150374816
    Abstract: The invention provides a method of treating a microbial infection in a subject and a method of improving an immune system response in a subject against a disease, condition, infection, or virus thereof, by administering an effective amount of a nucleoside, short oligonucleotide compound or an analog thereof, or a pharmaceutically acceptable salt, racemate, enantiomer, diastereomer, geometric isomer, or tautomer thereof. In addition, the invention provides methods for treating or preventing a viral infection, bacterial infection, parasitic infection, or fungal infection in a subject (such as, a human). The compounds of the invention include, for example, di-, and trinucleotide compounds as provided herein. The compounds of the invention are useful for different therapeutic applications including, such as, prophylactics and therapeutics. The invention also provides design and synthesis of a compound that is useful for various therapeutic applications as mentioned herein.
    Type: Application
    Filed: February 18, 2014
    Publication date: December 31, 2015
    Inventor: Radhakrishnan P. Iyer
  • Publication number: 20150329864
    Abstract: The invention relates to design of short oligonucleotides and analogs thereof (such as, di-, and trinucleotide compounds) useful for various therapeutic applications. It is believed that the compounds of the invention can be used as antiviral agents, anticancer agents and so on. In certain embodiments, the compounds of the invention can modulate immune-stimulatory pathways and non-TLR pathways. The invention also relates to design modified oligonucleotides for therapeutic applications, by excluding nucleotide segments having off-target effects from the modified oligonucleotides. In another aspect, the invention provides pharmaceutical compositions including one or more compounds of the invention. It is believed that the compounds and compositions as described herein have therapeutic utility against a variety of diseases, including viral diseases, autoimmune diseases (such as, allergy, asthma, and inflammatory disorders) and cancer.
    Type: Application
    Filed: April 20, 2015
    Publication date: November 19, 2015
    Applicant: SPRING BANK PHARMACEUTICALS, INC.
    Inventors: Radhakrishnan P. Iyer, John Edward Coughlin
  • Patent number: 9138442
    Abstract: The present invention provides compositions methods for treating susceptible viral infections, especially hepatitis C viral (HCV) infections as well as co infections of HCV with other viruses such as HBV and/or HIV. In one embodiment, the present invention provides compositions having the formula (I) and their use in treating viral infections: or a pharmaceutically acceptable salt, ester, stereoisomer, tautomers, solvate, prodrug, or combination thereof.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: September 22, 2015
    Assignee: SPRING BANK PHARMACEUTICALS, INC.
    Inventors: Radhakrishnan P. Iyer, Seetharamaiyer Padmanabhan
  • Patent number: 9040234
    Abstract: The invention relates to design of short oligonucleotides and analogs thereof (such as, di-, and trinucleotide compounds) useful for various therapeutic applications. It is believed that the compounds of the invention can be used as antiviral agents, anticancer agents and so on. In certain embodiments, the compounds of the invention can modulate immune-stimulatory pathways and non-TLR pathways. The invention also relates to design modified oligonucleotides for therapeutic applications, by excluding nucleotide segments having off-target effects from the modified oligonucleotides. In another aspect, the invention provides pharmaceutical compositions including one or more compounds of the invention. It is believed that the compounds and compositions as described herein have therapeutic utility against a variety of diseases, including viral diseases, autoimmune diseases (such as, allergy, asthma, and inflammatory disorders) and cancer.
    Type: Grant
    Filed: August 25, 2011
    Date of Patent: May 26, 2015
    Assignee: SPRING BANK PHARMACEUTICALS, INC.
    Inventors: Radhakrishnan P. Iyer, John E. Coughlin