Patents by Inventor Radwan Kiwan

Radwan Kiwan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ALKYL CHAIN MODIFIED IMIDAZOQUINOLINE TLR7/8 AGONIST COMPOUNDS AND USES THEREOF
    Publication number: 20240368155
    Abstract: Disclosed are alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, as Toll-like receptor-7 and -8 agonists for enhancing immune responses. Also provided are methods of making pharmaceutical compositions containing these compounds. The present disclosure also describes methods of use for the alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, and pharmaceutical compositions containing these compounds for the treatment of disease in a subject.
    Type: Application
    Filed: April 8, 2024
    Publication date: November 7, 2024
    Applicant: Dynavax Technologies Corporation
    Inventors: Stewart D. CHIPMAN, Radwan KIWAN, Melissa A. KACHURA, Robert COFFMAN
  • Alkyl chain modified imidazoquinoline TLR7/8 agonist compounds and uses thereof
    Patent number: 11981670
    Abstract: Disclosed are alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, as Toll-like receptor-7 and -8 agonists for enhancing immune responses. Also provided are methods of making pharmaceutical compositions containing these compounds. The present disclosure also describes methods of use for the alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, and pharmaceutical compositions containing these compounds for the treatment of disease in a subject.
    Type: Grant
    Filed: August 16, 2021
    Date of Patent: May 14, 2024
    Assignee: Dynavax Technologies Corporation
    Inventors: Stewart D. Chipman, Radwan Kiwan, Melissa A. Kachura, Robert Coffman
  • ALKYL CHAIN MODIFIED IMIDAZOQUINOLINE TLR7/8 AGONIST COMPOUNDS AND USES THEREOF
    Publication number: 20220033400
    Abstract: Disclosed are alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, as Toll-like receptor-7 and -8 agonists for enhancing immune responses. Also provided are methods of making pharmaceutical compositions containing these compounds. The present disclosure also describes methods of use for the alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, and pharmaceutical compositions containing these compounds for the treatment of disease in a subject.
    Type: Application
    Filed: August 16, 2021
    Publication date: February 3, 2022
    Applicant: Dynavax Technologies Corporation
    Inventors: Stewart D. CHIPMAN, Radwan KIWAN, Melissa A. KACHURA, Robert COFFMAN
  • Alkyl chain modified imidazoquinoline TLR7/8 agonist compounds and uses thereof
    Patent number: 11124510
    Abstract: Disclosed are alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, as Toll-like receptor-7 and -8 agonists for enhancing immune responses. Also provided are methods of making pharmaceutical compositions containing these compounds. The present disclosure also describes methods of use for the alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, and pharmaceutical compositions containing these compounds for the treatment of disease in a subject.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: September 21, 2021
    Assignee: DYNAVAX TECHNOLOGIES CORPORATION
    Inventors: Stewart D. Chipman, Radwan Kiwan, Melissa A. Kachura, Robert Coffman
  • Cleavable conjugates of TLR7/8 agonist compounds, methods for preparation, and uses thereof
    Patent number: 10722591
    Abstract: The present disclosure relates to cleavable conjugates (for example, particle-based or antibody-based conjugates) of TLR7/8 agonists (for example, 1H-imidazo[4,5-c]quinoline derivatives) containing a conjugation linker, a cleavable linker, and a self-eliminating linker. The present disclosure also related to methods for preparation of the cleavable conjugates, uses thereof for stimulating an effective immune response, and uses thereof for the treatment of cancer.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: July 28, 2020
    Assignee: Dynavax Technologies Corporation
    Inventors: Robert L. Coffman, Stewart D. Chipman, Radwan Kiwan, Samuel Zalipsky, Gary S. Ott
  • ALKYL CHAIN MODIFIED IMIDAZOQUINOLINE TLR7/8 AGONIST COMPOUNDS AND USES THEREOF
    Publication number: 20200199124
    Abstract: Disclosed are alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, as Toll-like receptor-7 and -8 agonists for enhancing immune responses. Also provided are methods of making pharmaceutical compositions containing these compounds. The present disclosure also describes methods of use for the alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, and pharmaceutical compositions containing these compounds for the treatment of disease in a subject.
    Type: Application
    Filed: March 2, 2020
    Publication date: June 25, 2020
    Applicant: Dynavax Technologies Corporation
    Inventors: Stewart D. CHIPMAN, John DEMATTEI, Radwan KIWAN, Melissa A. KACHURA
  • Alkyl chain modified imidazoquinoline TLR7/8 agonist compounds and uses thereof
    Patent number: 10618896
    Abstract: Disclosed are alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, as Toll-like receptor-7 and -8 agonists for enhancing immune responses. Also provided are methods of making pharmaceutical compositions containing these compounds. The present disclosure also describes methods of use for the alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, and pharmaceutical compositions containing these compounds for the treatment of disease in a subject.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: April 14, 2020
    Assignee: Dynavax Technologies Corporation
    Inventors: Stewart D. Chipman, John Demattei, Radwan Kiwan, Melissa A. Kachura
  • Branched chimeric compounds, and methods of use thereof
    Patent number: 10548975
    Abstract: The present disclosure relates to branched and linear chimeric compounds containing both nucleic acid and non-nucleic acid moieties, as well as to polynucleotides. The present disclosure also relates to uses thereof for stimulating an immune response, and to methods for preparation of the branched chimeric compounds.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: February 4, 2020
    Assignee: DYNAVAX TECHNOLOGIES CORPORATION
    Inventors: Gary S. Ott, Robert J. Milley, Robert L. Coffman, Radwan Kiwan, Holger Kanzler
  • BRANCHED CHIMERIC COMPOUNDS, AND METHODS OF USE THEREOF
    Publication number: 20190240323
    Abstract: The present disclosure relates to branched and linear chimeric compounds containing both nucleic acid and non-nucleic acid moieties, as well as to polynucleotides. The present disclosure also relates to uses thereof for stimulating an immune response, and to methods for preparation of the branched chimeric compounds.
    Type: Application
    Filed: April 20, 2018
    Publication date: August 8, 2019
    Inventors: Gary S. OTT, Robert J. MILLEY, Robert L. COFFMAN, Radwan KIWAN, Holger KANZLER
  • Linear chimeric compounds and methods of use thereof
    Patent number: 10350290
    Abstract: The present disclosure relates to branched and linear chimeric compounds containing both nucleic acid and non-nucleic acid moieties, as well as to polynucleotides. The present disclosure also relates to uses thereof for stimulating an immune response, and to methods for preparation of the branched chimeric compounds.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: July 16, 2019
    Assignee: DYNAVAX TECHNOLOGIES CORPORATION
    Inventors: Gary S. Ott, Robert J. Milley, Robert L. Coffman, Radwan Kiwan, Holger Kanzler
  • CLEAVABLE CONJUGATES OF TLR7/8 AGONIST COMPOUNDS, METHODS FOR PREPARATION, AND USES THEREOF
    Publication number: 20190151462
    Abstract: The present disclosure relates to cleavable conjugates (for example, particle-based or antibody-based conjugates) of TLR7/8 agonists (for example, 1H-imidazo[4,5-c]quinoline derivatives) containing a conjugation linker, a cleavable linker, and a self-eliminating linker. The present disclosure also related to methods for preparation of the cleavable conjugates, uses thereof for stimulating an effective immune response, and uses thereof for the treatment of cancer.
    Type: Application
    Filed: November 13, 2018
    Publication date: May 23, 2019
    Applicant: Dynavax Technologies Corporation
    Inventors: Robert L. COFFMAN, Stewart D. CHIPMAN, Radwan KIWAN, Samuel ZALIPSKY, Gary S. OTT
  • ALKYL CHAIN MODIFIED IMIDAZOQUINOLINE TLR7/8 AGONIST COMPOUNDS AND USES THEREOF
    Publication number: 20190062329
    Abstract: Disclosed are alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, as Toll-like receptor-7 and -8 agonists for enhancing immune responses. Also provided are methods of making pharmaceutical compositions containing these compounds. The present disclosure also describes methods of use for the alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, and pharmaceutical compositions containing these compounds for the treatment of disease in a subject.
    Type: Application
    Filed: August 21, 2018
    Publication date: February 28, 2019
    Applicant: Dynavax Technologies Corporation
    Inventors: Stewart D. CHIPMAN, John DEMATTEI, Radwan KIWAN, Melissa A. KACHURA
  • BRANCHED AND LINEAR CHIMERIC COMPOUNDS, POLYNUCLEOTIDES, USES AND METHODS FOR PREPARATION THEREOF
    Publication number: 20180360954
    Abstract: The present disclosure relates to branched and linear chimeric compounds containing both nucleic acid and non-nucleic acid moieties, as well as to polynucleotides. The present disclosure also relates to uses thereof for stimulating an immune response, and to methods for preparation of the branched chimeric compounds.
    Type: Application
    Filed: April 20, 2018
    Publication date: December 20, 2018
    Inventors: Gary S. OTT, Robert J. MILLEY, Robert L. COFFMAN, Radwan KIWAN, Holger KANZLER
  • BRANCHED AND LINEAR CHIMERIC COMPOUNDS, POLYNUCLEOTIDES, USES AND METHODS FOR PREPARATION THEREOF
    Publication number: 20160213774
    Abstract: The present disclosure relates to branched and linear chimeric compounds containing both nucleic acid and non-nucleic acid moieties, as well as to polynucleotides. The present disclosure also relates to uses thereof for stimulating an immune response, and to methods for preparation of the branched chimeric compounds.
    Type: Application
    Filed: January 22, 2016
    Publication date: July 28, 2016
    Inventors: Gary S. Ott, Robert J. Milley, Robert L. Coffman, Radwan Kiwan, Holger Kanzler
  • Releasable linkage and compositions containing same
    Patent number: 7592307
    Abstract: A conjugate comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-, hydroxy- or carboxyl-containing ligand is described. The resulting conjugate is capable of releasing the parent amine, hydroxy, or carboxyl-containing compound via thiol-mediated cleavage. The system allows for delivery of various amino-, hydroxy-, or carboxy-containing drugs in the form of their thiolytically cleavable macromolecular conjugates.
    Type: Grant
    Filed: June 6, 2007
    Date of Patent: September 22, 2009
    Assignee: Alza Corporation
    Inventors: Samuel Zalipsky, Radwan Kiwan
  • Releasable linkage and compositions containing same
    Publication number: 20080279922
    Abstract: A conjugate comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-, hydroxy- or carboxyl-containing ligand is described. The resulting conjugate is capable of releasing the parent amine, hydroxy, or carboxyl-containing compound via thiol-mediated cleavage. The system allows for delivery of various amino-, hydroxy-, or carboxy-containing drugs in the form of their thiolytically cleavable macromolecular conjugates.
    Type: Application
    Filed: June 6, 2007
    Publication date: November 13, 2008
    Inventors: Samuel Zalipsky, Radwan Kiwan
  • Releasable linkage and compositions containing same
    Patent number: 7238368
    Abstract: A conjugate comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-, hydroxy- or carboxyl-containing ligand is described. The resulting conjugate is capable of releasing the parent amine, hydroxy, or carboxyl-containing compound via thiol-mediated cleavage. The system allows for delivery of various amino-, hydroxy-, or carboxy-containing drugs in the form of their thiolytically cleavable macromolecular conjugates.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: July 3, 2007
    Assignee: ALZA Corporation
    Inventors: Samuel Zalipsky, Radwan Kiwan
  • Macromolecular conjugates of bone morphogenetic protein-7
    Publication number: 20070015701
    Abstract: A modified bone morphogenetic protein (BMP, also referred to as bone morphogenic protein) composition is described. The bone morphogenetic protein, in one embodiment, is BMP-7 which is chemically modified with a hydrophilic polymer, such as poly(ethylene glycol).
    Type: Application
    Filed: May 31, 2006
    Publication date: January 18, 2007
    Inventors: Samuel Zalipsky, Francis Farrell, Beth Hill, Radwan Kiwan
  • Novel bioconjugation reactions for acylating polyethylene glycol reagents
    Publication number: 20060286657
    Abstract: A method for conjugation of PEG to a protein in an aqueous solution at a pH less than or equal to about 7.0 or neutral pH comprising combining an activated PEG reagent and a protein in the presence of an activating agent at a pH of less than about 7.0 or neutral pH. In one embodiment, the method produces mixed populations of moderately PEGylated proteins, including 1:1, 2:1, and 3:1 PEGylated proteins.
    Type: Application
    Filed: June 1, 2006
    Publication date: December 21, 2006
    Inventors: Samuel Zalipsky, Radwan Kiwan
  • Endogenously-formed conjugate of albumin
    Publication number: 20060058236
    Abstract: A conjugate formed in vivo and comprised of endogenous albumin and an amine-containing compound, such as a protein or a drug, is described. The conjugate is formed by in vivo cleavage of a polymer-dithiobenzyl-therapeutic agent conjugate to form an albumin-dithiobenzyl-therapeutic agent conjugate. The dithiol moiety of the albumin-therapeutic agent conjugate is cleaved in vivo to yield the free therapeutic agent in native form.
    Type: Application
    Filed: August 31, 2005
    Publication date: March 16, 2006
    Inventors: Maria Hutchins, Radwan Kiwan, Samuel Zalipsky