Abstract: By adopting nature's biopolymer-phase-separation process, a highly scalable biomimetic bottom-up nanofabrication method is developed to create low-aspect-ratio bioinspired nanostructures (BINS) on freestanding silicon-nitride (Si3N4) membranes. Unlike previous high-aspect-ratio nonstructures that focused on replicating optical antireflection and bactericidal properties, the IOP sensor with BINS (or BINS-IOP sensor) of the present disclosure has a pseudo-periodic arrangement and dimensions that control short-range scattering to enhance omnidirectional optical transmission and angle independence while also exhibiting anti-biofouling properties of high-aspect-ratio nanostructures, which typically rely on physical cell lysis. In some embodiments, the BINS-IOP sensor can have a low-aspect-ratio, which displays strong hydrophilicity to form an aqueous anti-adhesion barrier for proteins and cellular fouling without cell lysis.