Patents by Inventor Raf Ponsaerts

Raf Ponsaerts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROTEIN-BASED CONJUGATION CARRIERS
    Publication number: 20240415974
    Abstract: The present technology relates to the field of drug delivery and provides molecules comprising or consisting of at least one protein-based carrier building block, wherein the protein-based carrier building block comprises at least one, preferably at least two, attachment point(s) or conjugation site(s). In particular, the technology provides a molecule comprising at least one protein-based building block, wherein the at least one protein-based building block: a) comprises at least one conjugation site or attachment point; b) has a molecular mass of 2.5 to 70 kDa; c) has a globular three-dimensional (3D) structure; d) has a solubility of 10 mg/ml or more, measured in an aqueous solution at room temperature; and does not specifically bind to any human protein or binds one or more human proteins with a KD value greater than 5×10?4 mol/litre.
    Type: Application
    Filed: December 22, 2023
    Publication date: December 19, 2024
    Applicant: Ablynx N.V.
    Inventors: Carlo Boutton, Peter Casteels, Alexandra Ferrier Berthelot, Raf Ponsaerts, John Reed
  • IMPROVED SERUM ALBUMIN BINDING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS
    Publication number: 20230050615
    Abstract: The present invention relates to amino acid sequences that can bind to serum albumin. In particular, the present invention relates to immunoglobulin single variable domains, and in particular heavy-chain immunoglobulin single variable domains, that can bind to serum albumin. The invention also relates to proteins, polypeptides and other constructs, compounds, molecules or chemical entities that comprise at least one of the immunoglobulin single variable domains binding to serum albumin that are described herein.
    Type: Application
    Filed: June 29, 2022
    Publication date: February 16, 2023
    Applicant: Ablynx N.V.
    Inventors: Stephanie Staelens, Soren Steffensen, Erika Morizzo, Raf Ponsaerts, Ingrid Ottevaere, An Cerdobbel
  • Serum albumin binding immunoglobulin single variable domains
    Patent number: 11414480
    Abstract: The present invention relates to amino acid sequences that can bind to serum albumin. In particular, the present invention relates to immunoglobulin single variable domains, and in particular heavy-chain immunoglobulin single variable domains, that can bind to serum albumin. The invention also relates to proteins, polypeptides and other constructs, compounds, molecules or chemical entities that comprise at least one of the immunoglobulin single variable domains binding to serum albumin that are described herein.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: August 16, 2022
    Assignee: Ablynx N.V.
    Inventors: Stephanie Staelens, Soren Steffensen, Erika Morizzo, Raf Ponsaerts, Ingrid Ottevaere, An Cerdobbel
  • IMPROVED SERUM ALBUMIN BINDING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS
    Publication number: 20190367596
    Abstract: The present invention relates to amino acid sequences that can bind to serum albumin. In particular, the present invention relates to immunoglobulin single variable domains, and in particular heavy-chain immunoglobulin single variable domains, that can bind to serum albumin. The invention also relates to proteins, polypeptides and other constructs, compounds, molecules or chemical entities that comprise at least one of the immunoglobulin single variable domains binding to serum albumin that are described herein.
    Type: Application
    Filed: December 7, 2017
    Publication date: December 5, 2019
    Applicant: Ablynx N.V.
    Inventors: Stephanie Staelens, Soren Steffensen, Erika Morizzo, Raf Ponsaerts, Ingrid Ottevaere, An Cerdobbel