Patents by Inventor Raf Van De Plas

Raf Van De Plas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10540536
    Abstract: Imaging mass spectrometry (IMS) has become a prime tool for studying the distribution of biomolecules in tissue. Although IMS data sets can become very large, computational methods have made it practically feasible to search these experiments for relevant findings. However, these methods lack access to an important source of information that many human interpretations rely upon: anatomical insight. In this work, this need is addressed by (1) integrating a curated anatomical data source with an empirically acquired IMS data source, establishing an algorithm-accessible link between them; and (2) demonstrating the potential of such an IMS-anatomical atlas link by applying it toward automated anatomical interpretation of ion distributions in tissue.
    Type: Grant
    Filed: August 3, 2015
    Date of Patent: January 21, 2020
    Assignees: Katholieke Universiteit Leuven, K.U.Leuven R&D, Vanderbilt University
    Inventors: Richard M. Caprioli, Bart De Moor, Raf Van De Plas, Nico Verbeeck, Etienne Waelkens
  • Publication number: 20190236397
    Abstract: The present invention relates generally to a species (analyte) separation and analysis system, for instance a spectrometry system, comprising a processor for receiving and processing signals from said its detector to remove undesirable variation or noise before further processing into a spectrum, whereby the processor is programmed by a novel program for a normalization preprocessing of the signals of said separation and analysis system.
    Type: Application
    Filed: April 10, 2019
    Publication date: August 1, 2019
    Inventors: Bart DE MOOR, Raf VAN DE PLAS, Etienne WAELKENS
  • Patent number: 10268916
    Abstract: The present invention relates generally to a species (analyte) separation and analysis system, for instance a spectrometry system, comprising a processor for receiving and processing signals from said its detector to remove undesirable variation or noise before further processing into a spectrum, whereby the processor is programmed by a novel program for a normalization preprocessing of the signals of said separation and analysis system.
    Type: Grant
    Filed: April 12, 2011
    Date of Patent: April 23, 2019
    Assignee: KATHOLIEKE UNIVERSITEIT LEUVEN
    Inventors: Bart De Moor, Raf Van De Plas, Etienne Waelkens
  • Publication number: 20170220850
    Abstract: Imaging mass spectrometry (IMS) has become a prime tool for studying the distribution of biomolecules in tissue. Although IMS data sets can become very large, computational methods have made it practically feasible to search these experiments for relevant findings. However, these methods lack access to an important source of information that many human interpretations rely upon: anatomical insight. In this work, this need is addressed by (1) integrating a curated anatomical data source with an empirically acquired IMS data source, establishing an algorithm-accessible link between them; and (2) demonstrating the potential of such an IMS-anatomical atlas link by applying it toward automated anatomical interpretation of ion distributions in tissue.
    Type: Application
    Filed: August 3, 2015
    Publication date: August 3, 2017
    Inventors: Richard M. Caprioli, Bart De Moor, Raf Van De Plas, Nico Verbeeck, Etienne Waelkens
  • Patent number: 9501687
    Abstract: Systems and methods are provided for generating a model relating parameters generated via a first molecular imaging modality to parameters generated via a second molecular imaging modality. First and second feature extractors extract, from images of a region of interest obtained via respective first and second molecular imaging modalities, respective sets of parameters for respective first and second sets of locations. A mapping component associates respective locations of the first and second sets of locations according to their spatial relationship within the region of interest to produce a training set. Each example in the training set comprises a set of parameters associated with a location in the first set of locations and a set of parameters associated with a location in the second set. A modeling component generates a predictive model relating the parameters associated with the first modality with at least one parameter associated with the second modality.
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: November 22, 2016
    Assignee: Vanderbilt University
    Inventors: Richard Caprioli, Raf Van de Plas
  • Publication number: 20150131888
    Abstract: Systems and methods are provided for generating a model relating parameters generated via a first molecular imaging modality to parameters generated via a second molecular imaging modality. First and second feature extractors extract, from images of a region of interest obtained via respective first and second molecular imaging modalities, respective sets of parameters for respective first and second sets of locations. A mapping component associates respective locations of the first and second sets of locations according to their spatial relationship within the region of interest to produce a training set. Each example in the training set comprises a set of parameters associated with a location in the first set of locations and a set of parameters associated with a location in the second set. A modeling component generates a predictive model relating the parameters associated with the first modality with at least one parameter associated with the second modality.
    Type: Application
    Filed: May 21, 2013
    Publication date: May 14, 2015
    Inventors: Richard Caprioli, Raf Van de Plas
  • Publication number: 20130035867
    Abstract: The present invention relates generally to a species (analyte) separation and analysis system, for instance a spectrometry system, comprising a processor for receiving and processing signals from said its detector to remove undesirable variation or noise before further processing into a spectrum, whereby the processor is programmed by a novel program, for a normalization preprocessing of the signals of said separation and analysis system.
    Type: Application
    Filed: April 12, 2011
    Publication date: February 7, 2013
    Applicant: Katholieke Universiteit Leuven K.U. Leuven R & D,
    Inventors: Bart De Moor, Raf Van De Plas, Etienne Waelkens