Patents by Inventor Rafael CUBAS

Rafael CUBAS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230416680
    Abstract: Provided herein are methods of producing TILs via (i) pre-REP stimulation with a combination of interferon gamma (IFN?) and an anti-PD-1 antibody, with or without a CD40 agonist, and with or without an anti-CTLA-4 antibody (ii) various concentrations of IL-15 and IL-21, with or without low-concentration IL-2, with or without an AKT inhibitor (AKTi) during REP expansion and/or pre-REP expansion, (iii) low-concentration IL-2 and an AKTi during REP expansion and/or pre-REP expansion, (iv) the combination of (i) and (ii), or (v) the combination of (i) and (iii).
    Type: Application
    Filed: June 20, 2023
    Publication date: December 28, 2023
    Inventors: Tim ERICKSON, Andrew YUHAS, Rafael CUBAS
  • Publication number: 20230151103
    Abstract: The invention provides methods for identifying an individuals with a disease or disorder who is less likely to respond to immunotherapy alone, the method comprising determining the presence of a stromal gene signature in a sample from the individual, said signature comprising one or more of FAP, FN1, MMP2, PDGFRB, or THY, wherein an increase in the level of expression of the one or more genes in the stroma gene signature relative to a median level identifies an individual for treatment with an immunotherapy and with a suppressive stromal antagonist. In some aspects, the invention provides methods for treating an individual displaying the stromal gene signature. In other aspects, the invention provides kits for determining the presence of a stroma gene signature in a sample from an individual.
    Type: Application
    Filed: August 12, 2022
    Publication date: May 18, 2023
    Applicant: Genentech, Inc.
    Inventors: Priti HEGDE, Luciana MOLINERO, Sanjeev MARIATHASAN, Shannon TURLEY, Jillian ASTARITA, Rafael CUBAS, Yagai YANG
  • Publication number: 20190085087
    Abstract: The invention provides methods for identifying an individuals with a disease or disorder who is less likely to respond to immunotherapy alone, the method comprising determining the presence of a stromal gene signature in a sample from the individual, said signature comprising one or more of FAP, FN1, MMP2, PDGFRB, or THY, wherein an increase in the level of expression of the one or more genes in the stroma gene signature relative to a median level identifies an individual for treatment with an immunotherapy and with a suppressive stromal antagonist. In some aspects, the invention provides methods for treating an individual displaying the stromal gene signature. In other aspects, the invention provides kits for determining the presence of a stroma gene signature in a sample from an individual.
    Type: Application
    Filed: November 15, 2018
    Publication date: March 21, 2019
    Inventors: Priti HEGDE, Luciana MOLINERO, Sanjeev MARIATHASAN, Shannon TURLEY, Jillian ASTARITA, Rafael CUBAS, Yagai YANG