Patents by Inventor Rafael Fridman

Rafael Fridman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Galectin-3 cleavage as a marker for matrix metalloproteinase activity in cancer
    Patent number: 8349579
    Abstract: Provided are differential antibodies recognizing the cleaved and non-cleaved forms of matrix metalloproteinases (MMPs), and methods of using the antibodies as surrogate diagnostic markers for the presence of active MMPs in cancer, such as growing breast cancers.
    Type: Grant
    Filed: December 11, 2008
    Date of Patent: January 8, 2013
    Assignee: Wayne State University
    Inventors: Avraham Raz, Pratima Nangia-Makker, Rafael Fridman
  • Inhibitors of matrix metalloproteinases
    Patent number: 8093287
    Abstract: The present invention provides novel compounds of formulas I-IX, as described herein. Also provided are compositions of compounds of formulas I-IX, methods of making compounds of formulas I-IX, and methods of using compounds of formulas I-IX. The compounds of the invention can be used to inhibit matrix metalloproteinases, and are useful to treat conditions and diseases associated therewith.
    Type: Grant
    Filed: March 14, 2011
    Date of Patent: January 10, 2012
    Assignees: University of Notre Dame du Lac, Wayne State University
    Inventors: Mijoon Lee, Masahiro Ikejiri, Mayland Chang, Rafael Fridman, Shahriar Mobashery
  • INHIBITORS OF MATRIX METALLOPROTEINASES
    Publication number: 20110224275
    Abstract: The present invention provides novel compounds of formulas I-IX, as described herein. Also provided are compositions of compounds of formulas I-IX, methods of making compounds of formulas I-IX, and methods of using compounds of formulas I-IX. The compounds of the invention can be used to inhibit matrix metalloproteinases, and are useful to treat conditions and diseases associated therewith.
    Type: Application
    Filed: March 14, 2011
    Publication date: September 15, 2011
    Applicants: NOTRE DAME UNIVERSITY, WAYNE STATE UNIVERSITY
    Inventors: Mijoon Lee, Masahiro Ikejiri, Mayland Chang, Rafael Fridman, Shahriar Mobashery
  • Inhibitors of matrix metallaproteinases
    Patent number: 7928127
    Abstract: The present invention provides novel compounds of formulas I-IX, as described herein. Also provided are compositions of compounds of formulas I-IX, methods of making compounds of formulas I-IX, and methods of using compounds of formulas I-IX. The compounds of the invention can be used to inhibit matrix metalloproteinases, and are useful to treat conditions and diseases associated therewith.
    Type: Grant
    Filed: May 19, 2006
    Date of Patent: April 19, 2011
    Assignees: Notre Dame University, Wayne State University
    Inventors: Mijoon Lee, Masahiro Ikejiri, Mayland Chang, Rafael Fridman, Shahriar Mobashery
  • Galectin-3 cleavage as a marker for matrix metalloproteinase activity in cancer
    Publication number: 20090269779
    Abstract: Provided are differential antibodies recognizing the cleaved and non-cleaved forms of matrix metalloproteinases (MMPs), and methods of using the antibodies as surrogate diagnostic markers for the presence of active MMPs in cancer, such as growing breast cancers.
    Type: Application
    Filed: December 11, 2008
    Publication date: October 29, 2009
    Applicant: Wayne State University
    Inventors: Avraham Raz, Pratima Nangia-Makker, Rafael Fridman
  • Inhibitors of Matrix Metallaproteinases
    Publication number: 20090005420
    Abstract: The present invention provides novel compounds of formulas I-IX, as described herein. Also provided are compositions of compounds of formulas I-IX, methods of making compounds of formulas I-IX, and methods of using compounds of formulas I-IX. The compounds of the invention can be used to inhibit matrix metalloproteinases, and are useful to treat conditions and diseases associated therewith.
    Type: Application
    Filed: May 19, 2006
    Publication date: January 1, 2009
    Inventors: Mijoon Lee, Masahiro Ikejiri, Mayland Chang, Rafael Fridman, Shahriar Mobashery
  • Inhibitors of matrix metalloproteinases
    Patent number: 7144917
    Abstract: The invention provides compounds that inhibit MMPs; methods for treating or preventing cancer, angiogenesis, arthritis, connective tissue disease, cardiovascular disease, inflammation or autoimmune disease in a mammal; a method for inhibiting a matrix metalloproteinase in vivo or in vitro; and a method for imaging a tumor in vivo or in vitro.
    Type: Grant
    Filed: December 24, 2003
    Date of Patent: December 5, 2006
    Assignee: Wayne State University
    Inventors: Shahriar Mobashery, Rafael Fridman
  • Inhibitors of matrix metalloproteinases
    Publication number: 20040127478
    Abstract: The invention provides compounds that inhibit MMPs; methods for treating or preventing cancer, angiogenesis, arthritis, connective tissue disease, cardiovascular disease, inflammation or autoimmune disease in a mammal; a method for inhibiting a matrix metalloproteinase in vivo or in vitro; and a method for imaging a tumor in vivo or in vitro.
    Type: Application
    Filed: December 24, 2003
    Publication date: July 1, 2004
    Applicant: Wayne State University
    Inventors: Shahriar Mobashery, Rafael Fridman
  • Inhibitors of matrix metallaproteinases
    Patent number: 6703415
    Abstract: The invention provides compounds that inhibit MMPs; methods for treating or preventing cancer, angiogenesis, arthritis, connective tissue disease, cardiovascular disease, inflammation or autoimmune disease in a mammal; a method for inhibiting a matrix metalloproteinase in vivo or in vitro; and a method for imaging a tumor in vivo or in vitro.
    Type: Grant
    Filed: May 3, 2001
    Date of Patent: March 9, 2004
    Assignee: Wayne State University
    Inventors: Shahriar Mobashery, Rafael Fridman
  • Inhibitors of matrix metallaproteinases
    Publication number: 20020037916
    Abstract: The invention provides compounds that inhibit MMPs; methods for treating or preventing cancer, angiogenesis, arthritis, connective tissue disease, cardiovascular disease, inflammation or autoimmune disease in a mammal; a method for inhibiting a matrix metalloproteinase in vivo or in vitro; and a method for imaging a tumor in vivo or in vitro.
    Type: Application
    Filed: October 3, 2001
    Publication date: March 28, 2002
    Inventors: Shahriar Mobashery, Rafael Fridman