Abstract: Methods of producing an aqueous formulation of an antigen-binding protein or enhancing re-oxidation of an antigen-binding protein are disclosed. The methods comprise (a) contacting an aqueous solution comprising antigen-binding protein molecules with a charged depth filter under conditions sufficient to enhance re-oxidation of the antigen-binding protein molecules and achieve a decrease in the percentage of reduced antigen-binding protein molecules, compared to the percentage of reduced anti-gen-binding protein molecules observed prior to step (a); and (b) optionally, measuring the amount or relative amount of reduced antigen-binding protein molecules. Formulations comprising a re-oxidized antigen-binding protein are also described.

Abstract: A method of using factor rich product from umbilical cord mesenchymal stem cells to increase collagen and elastin in adult human skin.

Abstract: The instant disclosure is directed to a vaginal care composition that restores pH balance, and thereby reduces vaginal dryness, irritation, dyspareunia, post-coital bleeding, infections, vaginal and pelvic pain and increases vaginal lubrication. In some embodiments, the vaginal care s composition comprises stem cell-derived exosomes (e.g., mesenchymal stem cell (MSC)-derived exosomes), an antioxidant and a pH buffer. Another aspect of the disclosure is directed to methods for improving vaginal health by administering the vaginal care composition of the instant disclosure.

Abstract: An injection system including a housing having a first end and a second end opposite the first end, the housing defining an interior space, a needle having an unshielded state and a shielded state, the needle having a first end and a second end positioned opposite the first end, the second end having a piercing tip, at least a portion of the needle is positioned within the housing, and a syringe adapter connection interface configured to mate with a corresponding connection interface of a syringe adapter, with the syringe adapter connection interface having a membrane and defining a passageway.

Abstract: A syringe adapter includes an outer housing having a sidewall defining an interior space, a membrane housing positioned within the interior space of the outer housing and moveable from a first position within the outer housing to a second position within the outer housing spaced from the first position, with the membrane housing receiving a membrane, a needle hub connected to the outer housing and configured to be connected to a syringe, with the needle hub rotatable relative to the outer housing, and a needle connected to the needle hub. The needle having a first end and a second end positioned opposite the first end, with the second end of the needle received within the membrane when membrane housing is in the first position. The needle is rotatable relative to the needle hub.

Abstract: A valve including a valve seat, a valve shuttle movable among positions wherein the shuttle is sealed against the seat and wherein the shuttle is spaced from the seat, a first magnet associated with the shuttle, and a second magnet positioned to magnetically interact with the first magnet in one of attractively or repulsively in at least one of the positions of the shuttle.

Abstract: Disclosed are methods and compositions useful for treating patients with inflammatory, auto-immune and age related conditions. The disclosure relates to using Natural Killer cells and derivatives thereof in order to induce therapeutic benefit to patients affected by disease and conditions such as cancer, multiple sclerosis, rheumatoid arthritis, type I diabetes mellitus, thyroid autoimmune disease, psoriasis and inflammatory bowel diseases.

Abstract: A weighing plate supporting a dismantlable rack, comprising a deformable portion in proximity to the load-bearing rear edge of the weighing plate; the deformable portion comprises at least one deformable cut-out and at least one strain gauge unit mechanically coupled to the deformable portion that is adapted to measure deformation when at least one load is arranged on the shelf of the rack; and the at least one strain gauge unit is arranged in shear mode for measuring the deformation of the deformable portion.

Abstract: A production system and method of operating the production system. A fluid flows through a flow control device. The flow control device having an element that generates an acoustic signal indicative of a value of a parameter of the fluid in response to the fluid flowing through the flow control device. The processor receives the acoustic signal from the element, determines the value of the parameter of the fluid from the parameter of the acoustic signal, and changes an operation of the production system based on the value of the parameter of the fluid.

Abstract: Disclosed are methods and compositions useful for treating patients with inflammatory, auto-immune and age related conditions. The disclosure relates to using Natural Killer cells and derivatives thereof in order to induce therapeutic benefit to patients affected by disease and conditions such as cancer, multiple sclerosis, rheumatoid arthritis, type I diabetes mellitus, thyroid autoimmune disease, psoriasis and inflammatory bowel diseases. In some embodiments the disclosure permits physiological compensation for disease conditions by reduction of inflammatory cytokine levels in plasma and of senescent peripheral blood mononuclear cells thereby prolonging the time until medical intervention may be required. In alternate embodiments the disclosure permits physiological compensation for disease conditions by reduction of inflammatory cytokine levels in plasma and reduction of senescent peripheral blood mononuclear cells following medical intervention.

Abstract: Procedure for the thermal hydrolysis of organic matter in steady state, with a double steam explosion and total energy recovery, which consists, as a minimum, of the 1) feeding stage, stepped pressurization and sequential injection of low, medium and high pressure level steam; 2) first stage of hydrolysis by consecutive steam explosion operations with the production of medium pressure level steam and thermal reaction; 3) second stage of hydrolysis consisting of steam explosion and production of low pressure steam. An installation for the implementation of the process, which consists of comprising pumps for stepped pressurization, fluid-steam mixers, valves, mixers, decompression elements, tanks, piping and instrumentation and control systems.

Abstract: A method of assembling a substrate with a part is provided. The method includes a step of structuring the substrate by a pulsed laser. In one example, the substrate is metallic and the part is polymer-based. The structuring step engraves grooves into the substrate in a pattern determined by the relative motion of the beam and the substrate. The pattern is configured to provide improved adhesion between the structured substrate and a part after assembling the substrate and the part by laser welding. The method of assembling may further include a pre-treatment step of the structured surface to allow improve laser absorption during the welding assembling.

Abstract: Factor rich compositions produced from umbilical cord (UC) mesenchymal stem cells (MSCs) are described. Secretory UC MSCs in serum free culture conditions produce a factor rich conditioned medium which may be concentrated and filtered to obtain clinical grade products.

Abstract: The smart safety ladder is an electronic safety device installed to standard construction ladders to prevent misuse of the ladder and ultimately keep workers safe. The top two rungs of the ladder are equipped with motion sensors that once triggered, turn on a red light and a beeping warning. Another safety feature is a motion sensor and level sensor on the bottom rung that will trigger a green light and an audible sound that will notify the person that he or she is on the bottom step. The smart safety ladder has an on and off switch which will activate and deactivate the ladder's electronic sensors, lights, and alarm system when you open and close the A frame ladder. A safety lock switch may be used to keep the ladder locked in place in fully open position. The smart electrical safety system can be installed on all standard construction ladders.

Abstract: A control apparatus for an electromechanical-brake-booster of a vehicle, having: an electronic-device to control an electric-motor of the electromechanical-brake-booster so that an output piston, connected indirectly to the electric-motor, of the electromechanical-brake-booster is displaceable out of its initial-position by the controlled electric-motor, such that only after a displacement of the output-piston out of its initial-position by at least a predefined limit displacement travel does a frictional engagement exist between the output-piston and an input-piston that is indirectly connected to the brake-pedal and is displaced by the actuation of the brake-pedal, and such that a speed of the output-piston displaced out of its initial-position by less than the limit displacement travel is at first increased from a reference-speed to a maximum-speed and is then reduced from the maximum-speed to the reference-speed.

Abstract: A pneumatic tire assembly includes: a tread portion including one or more traction features; a first sidewall portion coupled to the tread portion; and a first bead portion coupled to the first sidewall portion; wherein the first sidewall portion includes multiangle first tread traction features positioned proximate the tread portion.

Abstract: A pneumatic tire assembly includes: a tread portion including one or more traction features; a first sidewall portion coupled to the tread portion; and a first bead portion coupled to the first sidewall portion; wherein the first sidewall portion includes first bead traction features positioned proximate the first bead portion.

Abstract: Methods of producing an aqueous formulation of an antigen-binding protein or enhancing re-oxidation of an antigen-binding protein are disclosed. The methods comprise (a) contacting an aqueous solution comprising antigen-binding protein molecules with a charged depth filter under conditions sufficient to enhance re-oxidation of the antigen-binding protein molecules and achieve a decrease in the percentage of reduced antigen-binding protein molecules, compared to the percentage of reduced anti-gen-binding protein molecules observed prior to step (a); and (b) optionally, measuring the amount or relative amount of reduced an¬tigen-binding protein molecules. Formulations comprising a re-oxidized antigen-binding protein are also described.

Abstract: Factor rich compositions produced from umbilical cord mesenchymal stem cells and processes for making and using same are described. The manufacturing process includes utilizing secretory UC MSCs, providing serum and growth factor free growth conditions, and performing filtration of the collected conditioned medium to obtain a clinical grade product.