Patents by Inventor Rafael Gonzalez

Rafael Gonzalez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230118424
    Abstract: A valve including a valve seat, a valve shuttle movable among positions wherein the shuttle is sealed against the seat and wherein the shuttle is spaced from the seat, a first magnet associated with the shuttle, and a second magnet positioned to magnetically interact with the first magnet in one of attractively or repulsively in at least one of the positions of the shuttle.
    Type: Application
    Filed: October 20, 2021
    Publication date: April 20, 2023
    Applicant: Baker Hughes Oilfield Operations LLC
    Inventors: Jose Rafael Gonzalez, Oscar Becerra Moreno
  • Publication number: 20230018682
    Abstract: Disclosed are methods and compositions useful for treating patients with inflammatory, auto-immune and age related conditions. The disclosure relates to using Natural Killer cells and derivatives thereof in order to induce therapeutic benefit to patients affected by disease and conditions such as cancer, multiple sclerosis, rheumatoid arthritis, type I diabetes mellitus, thyroid autoimmune disease, psoriasis and inflammatory bowel diseases.
    Type: Application
    Filed: July 27, 2022
    Publication date: January 19, 2023
    Inventors: Nickolas Chelyapov, Rafael Gonzalez
  • Publication number: 20220378196
    Abstract: A weighing plate supporting a dismantlable rack, comprising a deformable portion in proximity to the load-bearing rear edge of the weighing plate; the deformable portion comprises at least one deformable cut-out and at least one strain gauge unit mechanically coupled to the deformable portion that is adapted to measure deformation when at least one load is arranged on the shelf of the rack; and the at least one strain gauge unit is arranged in shear mode for measuring the deformation of the deformable portion.
    Type: Application
    Filed: May 11, 2020
    Publication date: December 1, 2022
    Applicant: DINACELL ELECTRÓNICA S.L.
    Inventor: Rafael GONZÁLEZ GALLEGOS
  • Patent number: 11480029
    Abstract: A production system and method of operating the production system. A fluid flows through a flow control device. The flow control device having an element that generates an acoustic signal indicative of a value of a parameter of the fluid in response to the fluid flowing through the flow control device. The processor receives the acoustic signal from the element, determines the value of the parameter of the fluid from the parameter of the acoustic signal, and changes an operation of the production system based on the value of the parameter of the fluid.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: October 25, 2022
    Assignee: BAKER HUGHES OILFIELD OPERATIONS LLC
    Inventors: Tarik Abdelfattah, Joshua Raymond Snitkoff, Ian Mitchell, Jose Rafael Gonzalez, David Lerohl, Roberto Failla
  • Patent number: 11446329
    Abstract: Disclosed are methods and compositions useful for treating patients with inflammatory, auto-immune and age related conditions. The disclosure relates to using Natural Killer cells and derivatives thereof in order to induce therapeutic benefit to patients affected by disease and conditions such as cancer, multiple sclerosis, rheumatoid arthritis, type I diabetes mellitus, thyroid autoimmune disease, psoriasis and inflammatory bowel diseases. In some embodiments the disclosure permits physiological compensation for disease conditions by reduction of inflammatory cytokine levels in plasma and of senescent peripheral blood mononuclear cells thereby prolonging the time until medical intervention may be required. In alternate embodiments the disclosure permits physiological compensation for disease conditions by reduction of inflammatory cytokine levels in plasma and reduction of senescent peripheral blood mononuclear cells following medical intervention.
    Type: Grant
    Filed: November 1, 2018
    Date of Patent: September 20, 2022
    Inventors: Nickolas Chelyapov, Rafael Gonzalez
  • Patent number: 11319216
    Abstract: Procedure for the thermal hydrolysis of organic matter in steady state, with a double steam explosion and total energy recovery, which consists, as a minimum, of the 1) feeding stage, stepped pressurization and sequential injection of low, medium and high pressure level steam; 2) first stage of hydrolysis by consecutive steam explosion operations with the production of medium pressure level steam and thermal reaction; 3) second stage of hydrolysis consisting of steam explosion and production of low pressure steam. An installation for the implementation of the process, which consists of comprising pumps for stepped pressurization, fluid-steam mixers, valves, mixers, decompression elements, tanks, piping and instrumentation and control systems.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: May 3, 2022
    Assignee: TE Consulting House 4 Plus, SL
    Inventor: Rafael Gonzalez Calvo
  • Patent number: 11292084
    Abstract: A method of assembling a substrate with a part is provided. The method includes a step of structuring the substrate by a pulsed laser. In one example, the substrate is metallic and the part is polymer-based. The structuring step engraves grooves into the substrate in a pattern determined by the relative motion of the beam and the substrate. The pattern is configured to provide improved adhesion between the structured substrate and a part after assembling the substrate and the part by laser welding. The method of assembling may further include a pre-treatment step of the structured surface to allow improve laser absorption during the welding assembling.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: April 5, 2022
    Assignee: LASER ENGINEERING APPLICATIONS S.A.
    Inventors: Anne Henrottin, Jose Antonio Ramos de Campos, Axel Kupisiewicz, Gabriel Morales Cid, Rafael González Higueras, Francisco Javier Navas Martos
  • Publication number: 20220033772
    Abstract: Factor rich compositions produced from umbilical cord (UC) mesenchymal stem cells (MSCs) are described. Secretory UC MSCs in serum free culture conditions produce a factor rich conditioned medium which may be concentrated and filtered to obtain clinical grade products.
    Type: Application
    Filed: October 14, 2021
    Publication date: February 3, 2022
    Inventors: Rafael Gonzalez, Toai Nguyen
  • Publication number: 20220018190
    Abstract: The smart safety ladder is an electronic safety device installed to standard construction ladders to prevent misuse of the ladder and ultimately keep workers safe. The top two rungs of the ladder are equipped with motion sensors that once triggered, turn on a red light and a beeping warning. Another safety feature is a motion sensor and level sensor on the bottom rung that will trigger a green light and an audible sound that will notify the person that he or she is on the bottom step. The smart safety ladder has an on and off switch which will activate and deactivate the ladder's electronic sensors, lights, and alarm system when you open and close the A frame ladder. A safety lock switch may be used to keep the ladder locked in place in fully open position. The smart electrical safety system can be installed on all standard construction ladders.
    Type: Application
    Filed: July 17, 2020
    Publication date: January 20, 2022
    Inventor: Rafael Gonzalez
  • Patent number: 11225237
    Abstract: A control apparatus for an electromechanical-brake-booster of a vehicle, having: an electronic-device to control an electric-motor of the electromechanical-brake-booster so that an output piston, connected indirectly to the electric-motor, of the electromechanical-brake-booster is displaceable out of its initial-position by the controlled electric-motor, such that only after a displacement of the output-piston out of its initial-position by at least a predefined limit displacement travel does a frictional engagement exist between the output-piston and an input-piston that is indirectly connected to the brake-pedal and is displaced by the actuation of the brake-pedal, and such that a speed of the output-piston displaced out of its initial-position by less than the limit displacement travel is at first increased from a reference-speed to a maximum-speed and is then reduced from the maximum-speed to the reference-speed.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: January 18, 2022
    Assignee: Robert Bosch GmbH
    Inventors: Dominic Zipprich, Benno Schmieg, Rafael Gonzalez Romero
  • Publication number: 20220001702
    Abstract: A pneumatic tire assembly includes: a tread portion including one or more traction features; a first sidewall portion coupled to the tread portion; and a first bead portion coupled to the first sidewall portion; wherein the first sidewall portion includes first bead traction features positioned proximate the first bead portion.
    Type: Application
    Filed: July 1, 2021
    Publication date: January 6, 2022
    Inventor: Antonio Rafael Gonzalez
  • Publication number: 20220001703
    Abstract: A pneumatic tire assembly includes: a tread portion including one or more traction features; a first sidewall portion coupled to the tread portion; and a first bead portion coupled to the first sidewall portion; wherein the first sidewall portion includes multiangle first tread traction features positioned proximate the tread portion.
    Type: Application
    Filed: July 1, 2021
    Publication date: January 6, 2022
    Inventor: Antonio Rafael Gonzalez
  • Publication number: 20210363180
    Abstract: Methods of producing an aqueous formulation of an antigen-binding protein or enhancing re-oxidation of an antigen-binding protein are disclosed. The methods comprise (a) contacting an aqueous solution comprising antigen-binding protein molecules with a charged depth filter under conditions sufficient to enhance re-oxidation of the antigen-binding protein molecules and achieve a decrease in the percentage of reduced antigen-binding protein molecules, compared to the percentage of reduced anti-gen-binding protein molecules observed prior to step (a); and (b) optionally, measuring the amount or relative amount of reduced an¬tigen-binding protein molecules. Formulations comprising a re-oxidized antigen-binding protein are also described.
    Type: Application
    Filed: July 28, 2021
    Publication date: November 25, 2021
    Inventors: Hai Hoang, Rafael Gonzalez, Junfen Ma
  • Publication number: 20210355437
    Abstract: Factor rich compositions produced from umbilical cord mesenchymal stem cells and processes for making and using same are described. The manufacturing process includes utilizing secretory UC MSCs, providing serum and growth factor free growth conditions, and performing filtration of the collected conditioned medium to obtain a clinical grade product.
    Type: Application
    Filed: July 30, 2021
    Publication date: November 18, 2021
    Applicant: RESTEM LLC
    Inventors: Rafael Gonzalez, Toai Nguyen
  • Patent number: 11098079
    Abstract: Methods of producing an aqueous formulation of an antigen-binding protein or enhancing re-oxidation of an antigen-binding protein are disclosed. The methods comprise (a) contacting an aqueous solution comprising antigen-binding protein molecules with a charged depth filter under conditions sufficient to enhance re-oxidation of the antigen-binding protein molecules and achieve a decrease in the percentage of reduced antigen-binding protein molecules, compared to the percentage of reduced antigen-binding protein molecules observed prior to step (a); and (b) optionally, measuring the amount or relative amount of reduced antigen-binding protein molecules. Formulations comprising a re-oxidized antigen-binding protein are also described.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: August 24, 2021
    Assignee: AMGEN INC.
    Inventors: Hai Hoang, Rafael Gonzalez, Junfen Ma
  • Patent number: 11078008
    Abstract: An insulating insert for a packaging system includes six pockets and multiple sealed dividers. The six pockets are rectangular in shape and are each filled with an insulating material. The six pockets include a bottom pocket configured to contact a bottom inside surface of a box, four side pockets each configured to contact a respective side inside surface of the box, and a top pocket configured to contact a top inside surface of the box when the insulating insert is placed into the box. Each sealed divider is located between two adjacent pockets. The sealed dividers provide fold locations to permit the insulating insert to be folded and installed within the box so that each of the six pockets contacts a respective inside surface of the box.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: August 3, 2021
    Assignee: Smurfit Kappa North America LLC
    Inventors: Jeroen Joop Dankbaar, Renuka Deshpande, Gregory Vorce Hall, Rafael Gonzalez Rosas
  • Publication number: 20210230540
    Abstract: The present disclosure relates to compositions of ULSCs and/or conditioned media thereof. In particular, the disclosure relates to conditioned media containing therapeutic factors including growth factors, cytokines, chemokines and extra cellular matrix components.
    Type: Application
    Filed: March 18, 2021
    Publication date: July 29, 2021
    Inventor: Rafael Gonzalez
  • Patent number: 11066643
    Abstract: The present disclosure generally relates to compositions of NK cells for adoptive transfer. In particular, the disclosure relates to enhancing viability, proliferation and cytotoxicity of feeder-free NK cells following cryopreservation.
    Type: Grant
    Filed: May 13, 2020
    Date of Patent: July 20, 2021
    Inventors: Nickolas Chelyapov, Rafael Gonzalez
  • Patent number: 10975675
    Abstract: A supersonic vacuum generator device for oil wells including: a cylindrical chamber; a suction device; a central accelerator core inside the cylindrical chamber; a tubular chamber connected to the cylindrical chamber, the tubular chamber including an internal fluid feed space; a concentric accelerator core inside the tubular chamber and connected to the central accelerator core, the concentric accelerator core includes a central vacuum tube having a cylindrical shape with a fluid accumulation chamber; a conical section connected to the fluid accumulation chamber and to a reduced diameter fluid passage that diverges with an angle range between 3.5 to 9 degrees with respect to a center line of the fluid passage; a one-way valve located on each one of the inlets of the central accelerator core; and a one-way valve located on the central vacuum tube.
    Type: Grant
    Filed: August 12, 2019
    Date of Patent: April 13, 2021
    Inventor: Jose Rafael Gonzalez Castillo
  • Patent number: D998791
    Type: Grant
    Filed: January 22, 2020
    Date of Patent: September 12, 2023
    Assignee: Becton, Dickinson and Company
    Inventors: Rafael Gonzalez Macias, Jude Cancellieri