Patents by Inventor Rafael Jaimes

Rafael Jaimes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enzyme-dependent fluorescence recovery of NADH after photobleaching to assess dehydrogenase activity of living tissues
    Patent number: 11445950
    Abstract: The invention provides for a system for in vivo real time measurement of NADH recovery kinetics, comprising: 1) a specific pulse sequence to non-destructively, yet effectively, photobleach NADH for measurement of NADH recovery kinetics; 2) illumination light parameters to acquire NADH fluorescence before and after photobleaching, without causing fluorescence bleaching artifacts, for measurement of NADH recovery kinetics; and 3) configurations for devices capable of photobleaching NADH by at least 10% within tissues for effective measurement of NADH recovery kinetics in tissues within a living subject or excised tissues and organs.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: September 20, 2022
    Assignee: The George Washington University
    Inventors: Matthew Kay, Angel Moreno, Rafael Jaimes
  • ENZYME-DEPENDENT FLUORESCENCE RECOVERY OF NADH AFTER PHOTOBLEACHING TO ASSESS DEHYDROGENASE ACTIVITY OF LIVING TISSUES
    Publication number: 20190183395
    Abstract: The invention provides for a system for in vivo real time measurement of NADH recovery kinetics, comprising: 1) a specific pulse sequence to non-destructively, yet effectively, photobleach NADH for measurement of NADH recovery kinetics; 2) illumination light parameters to acquire NADH fluorescence before and after photobleaching, without causing fluorescence bleaching artifacts, for measurement of NADH recovery kinetics; and 3) configurations for devices capable of photobleaching NADH by at least 10% within tissues for effective measurement of NADH recovery kinetics in tissues within a living subject or excised tissues and organs.
    Type: Application
    Filed: February 26, 2019
    Publication date: June 20, 2019
    Inventors: Matthew Kay, Angel Moreno, Rafael Jaimes