Patents by Inventor Rafael Jimenez-Flores
Rafael Jimenez-Flores has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12225916Abstract: Disclosed herein is a process for isolating phospholipids from milk by-products, such as acid whey, the process comprising: a) exposing milk by-products to filtration, thereby enriching for phospholipids; and b) solubilizing and removing whey proteins and caseins; thereby isolating phospholipids from the milk by-product. Also disclosed are products produced by this method.Type: GrantFiled: March 25, 2020Date of Patent: February 18, 2025Assignee: Ohio State Innovation FoundationInventors: Rafael Jimenez-Flores, Joana Ortega-Anaya
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Publication number: 20230329259Abstract: Disclosed herein is a process for preparing a stable suspension of a globular protein material in a dairy product. Also disclosed are products produced by this method.Type: ApplicationFiled: April 13, 2023Publication date: October 19, 2023Inventors: Rafael Jimenez-Flores, Joana Ortega-Anaya, Alba Mayta Apaza, Stiphany Tieu
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Patent number: 11653661Abstract: Disclosed herein is a process for preparing a stable suspension of a globular protein material in a dairy product. Also disclosed are products produced by this method.Type: GrantFiled: August 14, 2020Date of Patent: May 23, 2023Assignee: Ohio State Innovation FoundationInventors: Rafael Jimenez-Flores, Joana Ortega-Anaya, Alba Mayta Apaza, Stiphany Tieu
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Publication number: 20220195449Abstract: Increased antigenicity of a membrane-bound polypeptide produced from a plant is provided in a process in which extraction of the polypeptide or other compounds from the plant is such that phospholipids are associated with the polypeptide. Reducing fat by supercritical fluid extraction increases antigenicity of such plant-produced membrane-bound polypeptides. Methods and means of producing such membrane-bound polypeptides are provided. Methods to produce a protective response in animals are provided by administering to the animal the membrane-bound polypeptide. Binding of antibody specific to the membrane-bound polypeptide is increased. The process provides for increased preferred formation of the membrane-bound polypeptide. Stability of the membrane-bound polypeptide is increased when the plant material is defatted.Type: ApplicationFiled: November 19, 2021Publication date: June 23, 2022Inventors: John Howard, Celine Hayden, Rafael Jimenez-Flores
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Publication number: 20210045398Abstract: Disclosed herein is a process for preparing a stable suspension of a globular protein material in a dairy product. Also disclosed are products produced by this method.Type: ApplicationFiled: August 14, 2020Publication date: February 18, 2021Inventors: Rafael Jimenez-Flores, Joana Ortega-Anaya, Alba Mayta Apaza, Stiphany Tieu
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Publication number: 20190024105Abstract: Increased antigenicity of a membrane-bound polypeptide produced from a plant is provided in a process in which extraction of the polypeptide or other compounds from the plant is such that phospholipids are associated with the polypeptide. Reducing fat by supercritical fluid extraction increases antigenicity of such plant-produced membrane-bound polypeptides. Methods and means of producing such membrane-bound polypeptides are provided. Methods to produce a protective response in animals are provided by administering to the animal the membrane-bound polypeptide. Binding of antibody specific to the membrane-bound polypeptide is increased. The process provides for increased preferred formation of the membrane-bound polypeptide. Stability of the membrane-bound polypeptide is increased when the plant material is defatted.Type: ApplicationFiled: October 10, 2018Publication date: January 24, 2019Inventors: John Howard, Celine Hayden, Rafael Jimenez-Flores
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Patent number: 10150970Abstract: Increased antigenicity of a membrane-bound polypeptide produced from a plant is provided in a process in which extraction of the polypeptide or other compounds from the plant is such that phospholipids are associated with the polypeptide. Reducing fat by supercritical fluid extraction increases antigenicity of such plant-produced membrane-bound polypeptides. Methods and means of producing such membrane-bound polypeptides are provided. Methods to produce a protective response in animals are provided by administering to the animal the membrane-bound polypeptide. Binding of antibody specific to the membrane-bound polypeptide is increased. The process provides for increased preferred formation of the membrane-bound polypeptide. Stability of the membrane-bound polypeptide is increased when the plant material is defatted.Type: GrantFiled: March 6, 2014Date of Patent: December 11, 2018Assignee: Applied Biotechnology Institute, Inc.Inventors: John Howard, Celine Hayden, Rafael Jimenez-Flores
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Publication number: 20180132518Abstract: A food product and process of making the same is provided which results in a high milk protein product having 10% to 25% milk protein content, higher phospholipids compared to unadulterated cow milk, a casein to whey ration of at least 50:50 and is shelf stable for at least six months. In the process whole milk and at least one milk protein source is mixed, heated and contacted with an acid or acidulating substance and co-precipitated to produce a semi-solid precipitate. The precipitate is mixed with starch and cooked.Type: ApplicationFiled: January 11, 2018Publication date: May 17, 2018Inventors: Rafael Jimenez- Flores, Andrea M. Laubscher
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Patent number: 9907330Abstract: A food product and process of making the same is provided which results in a high milk protein product having 10% to 25% milk protein content, higher phospholipids compared to unadulterated cow milk, a casein to whey ration of at least 50:50 and is shelf stable for at least six months. In the process whole milk and at least one milk protein source is mixed, heated and contacted with an acid or acidulating substance and co-precipitated to produce a semi-solid precipitate. The precipitate is mixed with starch and cooked.Type: GrantFiled: July 31, 2015Date of Patent: March 6, 2018Assignee: Cal Poly CorporationInventors: Rafael Jimenez-Flores, Andrea M Laubscher
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Publication number: 20160029645Abstract: A food product and process of making the same is provided which results in a high milk protein product having 10% to 25% milk protein content, higher phospholipids compared to unadulterated cow milk, a casein to whey ration of at least 50:50 and is shelf stable for at least six months. In the process whole milk and at least one milk protein source is mixed, heated and contacted with an acid or acidulating substance and co-precipitated to produce a semi-solid precipitate. The precipitate is mixed with starch and cooked.Type: ApplicationFiled: July 31, 2015Publication date: February 4, 2016Applicant: CAL POLY CORPORATIONInventors: Rafael Jimenez-Flores, Andrea M. Laubscher
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Publication number: 20140205625Abstract: Increased antigenicity of a membrane-bound polypeptide produced from a plant is provided in a process in which extraction of the polypeptide or other compounds from the plant is such that phospholipids are associated with the polypeptide. Reducing fat by supercritical fluid extraction increases antigenicity of such plant-produced membrane-bound polypeptides. Methods and means of producing such membrane-bound polypeptides are provided. Methods to produce a protective response in animals are provided by administering to the animal the membrane-bound polypeptide. Binding of antibody specific to the membrane-bound polypeptide is increased. The process provides for increased preferred formation of the membrane-bound polypeptide. Stability of the membrane-bound polypeptide is increased when the plant material is defatted.Type: ApplicationFiled: March 6, 2014Publication date: July 24, 2014Applicant: APPLIED BIOTECHNOLOGY INSTITUTE, INC.Inventors: John Howard, Celine Hayden, Rafael Jimenez-Flores
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Patent number: 7547770Abstract: A method (100) and a system (200) for processing mammalian bodily fluids to isolate target peptides and proteins. The method can include the steps of passing a mammalian bodily fluid through at least one ion exchange column (204). The ion exchange column can include an anionic resin and/or a cationic resin. The ion exchange column can be selected to remove large particles at a first pH level selected to remove such large particles at a maximum fluid pressure of 30 pounds per square inch (psi), for example less than 10 psi. The large particles can be released from the ion exchange column with a rinse solution having a pH selected for releasing the large particles. The pH of the fluid then can be adjusted to be a value less than 5.0, and the fluid can be filtered with a microfilter or ultrafilter (210).Type: GrantFiled: November 3, 2004Date of Patent: June 16, 2009Assignee: Advanced Protein SystemsInventors: Andrew Keech, Rafael Jimenez-Flores
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Publication number: 20050092684Abstract: A method (100) and a system (200) for processing mammalian bodily fluids to isolate target peptides and proteins. The method can include the steps of passing a mammalian bodily fluid through at least one ion exchange column (204). The ion exchange column can include an anionic resin and/or a cationic resin. The ion exchange column can be selected to remove large particles at a first pH level selected to remove such large particles at a maximum fluid pressure of 30 pounds per square inch (psi), for example less than 10 psi. The large particles can be released from the ion exchange column with a rinse solution having a pH selected for releasing the large particles. The pH of the fluid then can be adjusted to be a value less than 5.0, and the fluid can be filtered with a microfilter or ultrafilter (210).Type: ApplicationFiled: November 3, 2004Publication date: May 5, 2005Applicant: ADVANCED PROTEIN SYSTEMSInventors: Andrew Keech, Rafael Jimenez-Flores
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Patent number: 5326579Abstract: The present invention relates to a process for the removal of cholesterol from a processed or un processed dairy product, which process comprises: (a) obtaining a processed or unprocessed dairy product containing cholesterol (b) contacting the dairy product at a temperature of between about 35.degree. and 80.degree. C. with an amount of saponin effective to bind up to about 90% of the cholesterol present in the dairy product; (c) contacting a temperature of between about 35.degree. and 80.degree. C. the cholesterol:saponin with an effective amount of diatomaceous earth; (d) separating the insoluble cholesterol: saponin/diatomaceous earth by filtration or centrifugation; and (e) recovering the dairy product having a reduced content of cholesterol. The process particularly useful wherein the dairy product is selected form raw milk, pasteurized milk, raw cream, pasteurized cream, butteroil or anhydrous fat.Type: GrantFiled: July 6, 1992Date of Patent: July 5, 1994Assignee: The Regents of the University of CaliforniaInventors: Thomas Richardson, Rafael Jimenez-Flores
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Patent number: 4689245Abstract: A coffee whitener composition made from decreamed milk ultrafiltration retentate having its protein concentrated between about 2:1 to about 4:1 compared to the protein content of the starting milk and a minor whitening power enhancing amount is added in the form of riboflavin (a vitamin) and beta carotene (a vitamin precursor) or a mixture thereof. The composition is usually in powdered form and is high in protein, low in fat and sodium and reduced in lactose and its high protein enhanced as described provided a low-fat dairy coffee whitening function approximately equal to non-dairy coffee creamers.Type: GrantFiled: May 21, 1985Date of Patent: August 25, 1987Assignee: Cornell Research FoundationInventors: Frank V. Kosikowski, Rafael Jimenez-Flores
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Patent number: 4689151Abstract: A method of removing penicillin G and/or pharmaceutical antibiotics which contaminated milk by:(a) Subjecting the contaminated milk to an ultrafiltration process which produces a permeate containing the contamining antibiotic and a retentate comprising milk proteins and fats.(b) Adding a non-antibiotic containing retentate diluting (washing) aqueous fluid including uncontaminated ultrafiltered milk permeate, uncontaminated whole milk, uncontaminated skimmilk, or uncontaminated acid or sweet whey, or a mixture thereof to the retentate to dilute the retentate.(c) Subjecting the diluted (washed) retentate to the ultrafiltration process from additional antibiotic containing permeate thereby forming a milk product comprising retentate having a reduced level of or substantially free of antibiotics.Type: GrantFiled: May 21, 1985Date of Patent: August 25, 1987Assignee: Cornell Research Foundation, Inc.Inventors: Frank V. Kosikowski, Rafael Jimenez-Flores