Patents by Inventor Rafael Kramann

Rafael Kramann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Uses of GLI1 in detecting tissue fibrosis
    Patent number: 9970935
    Abstract: Methods are provided herein for the use of Gli-1 as a specific marker for myofibroblast progenitor cells, thereby permitting the diagnosis of early stages of fibrosis prior to the onset of organ failure. Also provided herein are methods of isolating Gli-1+ cells for e.g., use in high-throughput screening of compounds for the treatment or prevention of fibrosis. In another aspect, provided herein are methods of treating or preventing fibrosis (e.g., kidney fibrosis) in a subject by administering a Gli inhibitor, particularly a Gli-2 inhibitor or a Gli-1/Gli-2 inhibitor.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: May 15, 2018
    Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Benjamin D. Humphreys, Rafael Kramann, Derek Dirocco
  • USES OF GLI1 IN DETECTING TISSUE FIBROSIS
    Publication number: 20160341726
    Abstract: Methods are provided herein for the use of Gli-1 as a specific marker for myofibroblast progenitor cells, thereby permitting the diagnosis of early stages of fibrosis prior to the onset of organ failure. Also provided herein are methods of isolating Gli-1+ cells for e.g., use in high-throughput screening of compounds for the treatment or prevention of fibrosis. In another aspect, provided herein are methods of treating or preventing fibrosis (e.g., kidney fibrosis) in a subject by administering a Gli inhibitor, particularly a Gli-2 inhibitor or a Gli-1/Gli-2 inhibitor.
    Type: Application
    Filed: February 6, 2015
    Publication date: November 24, 2016
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Benjamin D. Humphreys, Rafael Kramann, Derek Dirocco