Patents by Inventor Rafael Labriola

Rafael Labriola has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRYSTALLINE FORM OF THE ZOLEDRONIC ACID, A PROCESS TO OBTAIN IT AND THE PHARMACEUTICAL COMPOSITION COMPRISING IT
    Publication number: 20100197935
    Abstract: A method to obtain a new crystalline form of the Zoledronic acid, characterized by its X-rays diffractogram as well as by its spatial atomic distribution in the red crystalline and its curves of thermal analysis. There is also included a method to obtain this crystalline form, which includes the synthesis of the corresponding acid and the pharmaceutical composition this crystalline form comprises.
    Type: Application
    Filed: February 4, 2010
    Publication date: August 5, 2010
    Applicant: GADOR S.A.
    Inventors: Rafael A. Labriola, Dora G. Tombari, Adriana Vecchioli
  • CRYSTALLINE FORM OF THE ZOLEDRONIC ACID, A PROCESS TO OBTAIN IT AND THE PHARMACEUTICAL COMPOSITION COMPRISING IT
    Publication number: 20080090784
    Abstract: A new crystalline form of the Zoledronic acid, characterized by its X-rays diffractogram as well as by its spatial atomic distribution in the red crystalline and its curves of thermal analysis. There is also included a method to obtain this crystalline form, which includes the synthesis of the corresponding acid and the pharmaceutical composition this crystalline form comprises.
    Type: Application
    Filed: August 10, 2007
    Publication date: April 17, 2008
    Applicant: Gador S.A.
    Inventors: Rafael Labriola, Dora Tombari, Adriana Vecchioli
  • Process for preparing N,N,6- trimethyl-2-(4-methylphenyl)-imidazo- [1,2-a]-pyridine- 3-acetamide and salts thereof
    Patent number: 6407240
    Abstract: It comprises reducing the hydroxy ester of formula (X) by reacting it in DMF and then with an iminium salt of formula (XIII) formed in situ with thionyl chloride and dimethylformamide, and subsequent reduction with an appropriate reducing agent to form the ester of formula (XII), which is then reacted with dimethylamine in a polyhydroxylated solvent medium at an appropriate
    Type: Grant
    Filed: April 13, 2001
    Date of Patent: June 18, 2002
    Assignee: Quimica Sintetica, S.A.
    Inventor: Rafael Labriola
  • Therapeutic use of 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid and its salts
    Patent number: 5990098
    Abstract: Use of 1-amino-3-N,N-dimethylamino)-propyliden-1,1-bisphosphonic acid of the structural formula: ##STR1## or of its monosodium or other pharmaceutically acceptable salt, as a biological carrier for bone active substances or for the preparation of a medicament for the diagnosis, prophylaxis and/or treatment of bone and/or mineral metabolism disorders.
    Type: Grant
    Filed: September 1, 1998
    Date of Patent: November 23, 1999
    Assignees: Gador, S.A., University of Leiden
    Inventors: Ermond R. Van Beek, Clemens W. G. M. Lowik, Socrates Papapoulos, Rafael Labriola, Adriana Vecchioli
  • Bone mass anabolic composition comprising olpadronate
    Patent number: 5885973
    Abstract: The present invention provides methods for bone mass anabolic preservation or augmentation in human or other animal subjects affected by osteoporosis or other metabolic bone disorder characterized by systemic or regional bone loss, using bisphosphonates formulations, wherein the bone mass anabolic composition contains effective non-toxic doses of ?3-(N,N-dimethylamine)-1-hydroxypropylidene!-bisphosphonic acid or olpadronate or the monosodium or other pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 10, 1997
    Date of Patent: March 23, 1999
    Assignees: Gador, S.A., University of Leiden
    Inventors: Socrates Papapoulos, Jose Luis Ferretti, Rafael A. Labriola, Nelida Mondelo, Emilio J.A. Roldan