Patents by Inventor Rafael Pieretti-Vanmarcke

Rafael Pieretti-Vanmarcke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Collecting ovarian cancer stem cells from ovarian cancer cells
    Patent number: 9289492
    Abstract: The present invention relates to compositions and methods for treating, characterizing and diagnosing ovarian cancer. In particular, the present invention provides methods for treating and/or preventing ovarian cancer in a subject by administering to the subject an effective amount of Mullerian Inhibiting substance and/or an effective amount of an agent that inhibits BCRP1. The present invention further provides methods to identify and/or enrich for populations of ovarian cancer stem cells and populations of somatic ovarian stem cells, in particular, enrichment for populations of coelomic somatic ovarian stem cells, subcoelomic/stromal somatic ovarian stem cells and periphilar medullary somatic ovarian stem cells. The present invention also provides somatic ovarian stem cell markers and ovarian cancer stem cell markers, as well as methods to identify agents which selectively inhibit the proliferation of ovarian cancer stem cells as compared to somatic ovarian stem cells.
    Type: Grant
    Filed: July 17, 2008
    Date of Patent: March 22, 2016
    Assignee: The General Hospital Corporation
    Inventors: Patricia K Donahoe, Paul P Szotek, David T MacLaughlin, Frederic Preffer, Rafael Pieretti-Vanmarcke, David Michael Dombkowski
  • METHODS TO IDENTIFY AND ENRICH FOR POPULATIONS OF OVARIAN CANCER STEM CELLS AND SOMATIC OVARIAN STEM CELLS AND USES THEREOF
    Publication number: 20100273160
    Abstract: The present invention relates to compositions and methods for treating, characterizing and diagnosing ovarian cancer. In particular, the present invention provides methods for treating and/or preventing ovarian cancer in a subject by administering to the subject an effective amount of Mullerian Inhibiting substance and/or an effective amount of an agent that inhibits BCRP1. The present invention further provides methods to identify and/or enrich for populations of ovarian cancer stem cells and populations of somatic ovarian stem cells, in particular, enrichment for populations of coelomic somatic ovarian stem cells, subcoelomic/stromal somatic ovarian stem cells and periphilar medullary somatic ovarian stem cells. The present invention also provides somatic ovarian stem cell markers and ovarian cancer stem cell markers, as well as methods to identify agents which selectively inhibit the proliferation of ovarian cancer stem cells as compared to somatic ovarian stem cells.
    Type: Application
    Filed: July 17, 2008
    Publication date: October 28, 2010
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Patricia K. Donahoe, Paul P. Szotek, David T. MacLaughlin, Frederic Preffer, Rafael Pieretti-Vanmarcke, David Michael Dombkowski