Patents by Inventor Rafael Vazquez-Martinez

Rafael Vazquez-Martinez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ISOFORMS OF THE HUMAN SST5 RECEPTOR ORIGINATED BY ALTERNATIVE SPLICING AND OLIGONUCLEOTIDE PAIRS TO DETECT THEM BY PCR
    Publication number: 20140248628
    Abstract: The present invention is referred to two human nucleic 5 acids that comprise sequences encoding two new isoforms of the human somatostatin receptor type 5 originated by alternative splicing, named sst5B and sst5C, with possible involvement in tumor processes. In addition, the invention is referred to oligonucleotide pairs allowing 10 their differential detection in several tissues using the PCR technique.
    Type: Application
    Filed: April 2, 2014
    Publication date: September 4, 2014
    Applicant: UNIVERSIDAD DE CORDOBA
    Inventors: Mario Durán Prado, Antonio Jesús Martinez Fuentes, Rafael Vazquez Martinez, Socorro Garcia Navarro, Maria del Mar Malagón Poyato, Justo Pastor Castaño Fuentes, Francisco Gracia-Navarro
  • Isoforms of human somatostatin receptor type 5
    Patent number: 8354273
    Abstract: The present invention concerns two human nucleic acids comprising sequences which code two novel isoforms of human somatostatin receptor type 5 produced by alternative adjustment, called sst5B and sst5C and with possible uses in tumoral processes. Additionally, the invention concerns oligonucleotide pairs used for the differential detection of said isoforms by means of the PCR technique in different tissues.
    Type: Grant
    Filed: October 17, 2007
    Date of Patent: January 15, 2013
    Assignee: Universidad de Cordoba
    Inventors: Mario Durán Prado, Antonio Jesús Martínez Fuentes, Rafael Vazquez Martínez, Socorro García Navarro, María del Mar Malagón Poyato, Justo Pastor Castaño Fuentes, Francisco Garcia-Navarro
  • ISOFORMS OF HUMAN SOMATOSTATIN RECEPTOR TYPE 5 PRODUCED BY ALTERNATIVE PROCESSING AND OLIGO-NUCLEOTIDE PAIRS FOR DETECTION THEREOF BY PCR
    Publication number: 20120003252
    Abstract: The present invention concerns two human nucleic acids comprising sequences which code two novel isoforms of human somatostatin receptor type 5 produced by alternative adjustment, called sst5B and sst5C and with possible uses in tumoral processes. Additionally, the invention concerns oligonucleotide pairs used for the differential detection of said isoforms by means of the PCR technique in different tissues.
    Type: Application
    Filed: October 17, 2007
    Publication date: January 5, 2012
    Inventors: Mario Durán Prado, Antonio Jesús Martínez Fuentes, Rafael Vazquez Martínez, Socorro García Navarro, María del Mar Malagón Poyato, Justo Pastor Castaño Fuentes, Francisco Garcia-Navarro
  • Methods for direct visualization of active synapses
    Patent number: 7923015
    Abstract: A method for visualizing an active synapse wherein said method comprises: (a) exposing cells forming the active synapse to a biomarker comprising at least fragment C of tetanus toxin and a reporter protein; and (b) visualizing the biomarker; wherein the accumulation of the biomarker into dendritic spines of the cells allows visualization of an active synapse. Also, a method for screening molecules capable of modulating synapse activity is provided. A kit useful for the early diagnosis of neurodegenerative disease comprises a biomarker comprising at least fragment C of tetanus toxin and a reporter protein.
    Type: Grant
    Filed: April 6, 2004
    Date of Patent: April 12, 2011
    Assignees: Institut Pasteur, Centre Nationale de la Recherche Scientifique
    Inventors: Rafael Vazquez-Martinez, Philippe Brulet
  • Methods for direct visualization of active synapses
    Publication number: 20070092449
    Abstract: A method for visualizing an active synapse wherein said method comprises: (a) exposing cells forming the active synapse to a biomarker comprising at least fragment C of tetanus toxin and a reporter protein; and (b) visualizing the biomarker; wherein the accumulation of the biomarker into dendritic spines of the cells allows visualization of an active synapse. Also, a method for screening molecules capable of modulating synapse activity is provided. A kit useful for the early diagnosis of neurodegenerative disease comprises a biomarker comprising at least fragment C of tetanus toxin and a reporter protein.
    Type: Application
    Filed: October 5, 2006
    Publication date: April 26, 2007
    Inventors: Rafael Vazquez-Martinez, Philippe Brulet
  • Methods for direct visualization of active synapses
    Publication number: 20050060761
    Abstract: A method for visualizing an active synapse wherein said method comprises: (a) exposing cells forming the active synapse to a biomarker comprising at least fragment C of tetanus toxin and a reporter protein; and (b) visualizing the biomarker; wherein the accumulation of the biomarker into dendritic spines of the cells allows visualization of an active synapse. Also, a method for screening molecules capable of modulating synapse activity is provided. A kit useful for the early diagnosis of neurodegenerative disease comprises a biomarker comprising at least fragment C of tetanus toxin and a reporter protein.
    Type: Application
    Filed: April 6, 2004
    Publication date: March 17, 2005
    Inventors: Rafael Vazquez-Martinez, Philippe Brulet