Patents by Inventor Rafal Fudala

Rafal Fudala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HDL MIMICKING TARGETED DRUG DELIVERY SYSTEM FOR THE TREATMENT OF SOLID TUMORS
    Publication number: 20240173256
    Abstract: The present disclosure is directed to an SR-B1-targeting nanomicelle and compositions, methods of synthesis and methods of use thereof. The nanomicelle may be an HDL-mimetic drug delivery system and may be cross-linked with DSS. The composition may contain a therapeutic agent with the ability to treat cancers, especially sarcomas.
    Type: Application
    Filed: November 28, 2023
    Publication date: May 30, 2024
    Applicant: University of North Texas Health Science Center
    Inventors: Nirupama SABNIS, Andras LACKO, Rafal FUDALA
  • FRET based multiplex probes
    Patent number: 9388450
    Abstract: The present invention includes compositions and methods for fluorescence-based multiplex probe to simultaneously detect one or more enzymatic activities comprising: a first enzymatic target having a first end and a second end, wherein the first end of the first enzymatic target is attached to a central body and the second end of the first enzymatic target is attached to a first fluorophore; a second enzymatic target having a first end and a second end, wherein the first end of the second enzymatic target is attached to the central body and the second end of the second enzymatic target is attached to a third fluorophore; wherein the central body comprises at least one second fluorophore; wherein the first enzymatic target comprises a specific cleavage site of a first enzyme that cleaves the first enzymatic target; and wherein the second enzymatic target comprises a specific cleavage site of a second enzyme.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: July 12, 2016
    Assignees: UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER, TEXAS CHRISTIAN UNIVERSITY
    Inventors: Zygmunt Gryczynski, Ignacy Gryczynski, Rafal Fudala, Badri P. Maliwal
  • FRET BASED MULTIPLEX PROBES
    Publication number: 20140274797
    Abstract: The present invention includes compositions and methods for fluorescence-based multiplex probe to simultaneously detect one or more enzymatic activities comprising: a first enzymatic target having a first end and a second end, wherein the first end of the first enzymatic target is attached to a central body and the second end of the first enzymatic target is attached to a first fluorophore; a second enzymatic target having a first end and a second end, wherein the first end of the second enzymatic target is attached to the central body and the second end of the second enzymatic target is attached to a third fluorophore; wherein the central body comprises at least one second fluorophore; wherein the first enzymatic target comprises a specific cleavage site of a first enzyme that cleaves the first enzymatic target; and wherein the second enzymatic target comprises a specific cleavage site of a second enzyme.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Inventors: Zygmunt Gryczynski, Ignacy Gryczynski, Rafal Fudala, Badri P. Maliwal