Patents by Inventor Raffi V. Aroian

Raffi V. Aroian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small molecule compounds that control mammal-pathogenic nematodes
    Patent number: 9487551
    Abstract: The present invention relates to methods of modifying nematode behavior using certain isolated modulator compounds. Also disclosed are methods of promoting or inhibiting reproduction in a nematode population, methods of promoting or inhibiting nematode aggregation at a mammal, and methods of treating or preventing parasite infection of a mammal.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: November 8, 2016
    Assignees: California Institute of Technology, Boyce Thompson Institute for Plant Research, The Regents of the University of California
    Inventors: Andrea Choe, Paul W. Sternberg, Frank C. Schroeder, Stephan H. Von Reuss, Raffi V. Aroian
  • Compositions and Methods Related to Parasites
    Publication number: 20150329603
    Abstract: In some aspects, the invention relates to compositions and methods for preventing or treating a hookworm infection. In some aspects, the invention relates to nucleic acids, peptides, proteins, antigens, and cells that encode, comprise, and/or express one or more hookworm amino acid sequences, e.g., for use in manufacturing a vaccine.
    Type: Application
    Filed: May 13, 2015
    Publication date: November 19, 2015
    Inventors: Erich M. Schwarz, Yan Hu, Igor Antoshechkin, Paul W. Sternberg, Raffi V. Aroian
  • Small Molecule Compounds that Control Mammal-Pathogenic Nematodes
    Publication number: 20140303102
    Abstract: The present invention relates to methods of modifying nematode behavior using certain isolated modulator compounds. Also disclosed are methods of promoting or inhibiting reproduction in a nematode population, methods of promoting or inhibiting nematode aggregation at a mammal, and methods of treating or preventing parasite infection of a mammal.
    Type: Application
    Filed: August 8, 2012
    Publication date: October 9, 2014
    Applicants: California Institute of Technology, Boyce Thompson Institute for Plant Research, The Regents of the University of California
    Inventors: Andrea Choe, Paul W. Sternberg, Frank C. Schroeder, Stephan H. Von Reuss, Raffi V. Aroian
  • Combination therapy to combat helminth resistance
    Patent number: 8809268
    Abstract: Pharmaceutical compositions having at least one crystal protein and a nicotinic acetylcholine receptor agonist in amounts effective to inhibit a parasitic worm or helminth infection in a vertebrate or mammal are described. Methods for treating a parasitic worm or helminth infection in a subject are also described. The methods include administering to the subject a therapeutically effective amount of the at least one crystal protein and a nicotinic acetylcholine receptor agonist. The crystal proteins can be isolated from Bacillus thuringiensis and include Cry5B, Cry21, Cry14A, Cry6A, and Cry13A. The nicotinic acetylcholine receptor agonist can be from the levamisole family, which include levamisole, pyrantel, and tribendimidine.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: August 19, 2014
    Assignee: The Regents of The University of California
    Inventors: Raffi V. Aroian, Yan Hu
  • COMBINATION THERAPY TO COMBAT HELMINTH RESISTANCE
    Publication number: 20110263489
    Abstract: Pharmaceutical compositions having at least one crystal protein and a nicotinic acetylcholine receptor agonist in amounts effective to inhibit a parasitic worm or helminth infection in a vertebrate or mammal are described. Methods for treating a parasitic worm or helminth infection in a subject are also described. The methods include administering to the subject a therapeutically effective amount of the at least one crystal protein and a nicotinic acetylcholine receptor agonist. The crystal proteins can be isolated from Bacillus thuringiensis and include Cry5B, Cry21, Cry14A, Cry6A, and Cry13A. The nicotinic acetylcholine receptor agonist can be from the levamisole family, which include levamisole, pyrantel, and tribendimidine.
    Type: Application
    Filed: October 29, 2009
    Publication date: October 27, 2011
    Applicant: The Regents of The University of California Office of Technology Transfer
    Inventors: Raffi V. Aroian, Yan Hu
  • Method for Controlling Plant-Parasitic Nematode Infections in Plants
    Publication number: 20100024075
    Abstract: The invention provides compositions having Bacillus thuringiensis Crystal (Cry) proteins including transgenic plants expressing those proteins, and methods of using those proteins to prevent, inhibit or treat parasitic infections in plants and vertebrates.
    Type: Application
    Filed: November 22, 2006
    Publication date: January 28, 2010
    Inventors: Raffi V. Aroian, Xiang-Oian Li
  • Methods for blocking resistance to bt toxins in insects and nematodes
    Publication number: 20030131378
    Abstract: Two genes involved in the resistance of insects to Bacillus thruingiensis toxins have been cloned providing an understanding of mechanisms of resistance to the toxins. Such an understanding allows for rational methods to modify or combine toxins to prevent or overcome Bt toxin resistance to improve crop protection.
    Type: Application
    Filed: February 10, 2003
    Publication date: July 10, 2003
    Inventor: Raffi V. Aroian