Patents by Inventor Rafi De Picciotto
Rafi De Picciotto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240131362Abstract: Various approaches for computationally generating a protocol for treatment of one or more target BBB regions within a tissue region of interest using a source of focused ultrasound include specifying (i) settings of sonication parameters for applying one or more sequence of sonications to the target BBB region using the source of focused ultrasound and (ii) a characteristic of microbubbles selected to be administered into the target BBB region; electronically simulating treatment in accordance with the protocol at least in part by computationally executing the sequence(s) of sonications and computationally administering the microbubbles having the characteristic; and computationally predicting a tissue disruption effect of the target BBB region resulting from the treatment.Type: ApplicationFiled: January 2, 2024Publication date: April 25, 2024Inventors: Yoav Levy, Rafi De Picciotto, Javier Grinfeld, Eyal Zadicario
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Patent number: 11918832Abstract: Systems and methods for applying ultrasound sonication to temporarily disrupt a patient's blood-brain barrier (BBB) include storing threshold values of an acoustic response level, an acoustic response dose and a tissue response dose associated with a target BBB region and its surrounding regions based on anatomical characteristics thereof; causing the ultrasound transducer to transmit one or more pulses/waves; measuring the acoustic response level, the acoustic response dose, and/or the tissue response dose associated with the target BBB region and/or its surrounding regions; comparing the measurement with a corresponding stored threshold value; and operating the transducer based at least in part on the comparison.Type: GrantFiled: May 22, 2018Date of Patent: March 5, 2024Assignee: Insightec Ltd.Inventors: Yoav Levy, Eyal Zadicario, Javier Grinfeld, Rafi De Picciotto
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Patent number: 11872085Abstract: Various approaches for generating an ultrasound focus at a target region and receiving signals therefrom using an ultrasound transducer having multiple transducer elements include acquiring multiple images of the target region and one or more path zones located on beam paths between the transducer elements and the target region; determining one or more tissue characteristics associated with the target region based on the acquired images; determining multiple profile parameters associated with each of the transducer elements based at least in part on the determined tissue characteristic; based at least in part on the profile parameters, operating at least first ones of the transducer elements to collectively transmit an ultrasound beam to the target region so as to create a focus thereon with desired properties; and based at least in part on the profile parameters, operating at least second ones of the transducer elements to receive acoustic signals from the target region and, in response thereto, adjusting opType: GrantFiled: June 4, 2019Date of Patent: January 16, 2024Assignee: INSIGHTEC, LTD.Inventors: Kobi Vortman, Rafi De Picciotto
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Patent number: 11857807Abstract: Various approaches for computationally generating a protocol for treatment of one or more target BBB regions within a tissue region of interest using a source of focused ultrasound include specifying (i) settings of sonication parameters for applying one or more sequence of sonications to the target BBB region using the source of focused ultrasound and (ii) a characteristic of microbubbles selected to be administered into the target BBB region; electronically simulating treatment in accordance with the protocol at least in part by computationally executing the sequence(s) of sonications and computationally administering the microbubbles having the characteristic; and computationally predicting a tissue disruption effect of the target BBB region resulting from the treatment.Type: GrantFiled: June 29, 2018Date of Patent: January 2, 2024Assignee: INSIGHTEC, LTD.Inventors: Yoav Levy, Rafi De Picciotto, Javier Grinfeld, Eyal Zadicario
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Publication number: 20230201553Abstract: Systems and methods for temporarily altering a tissue characteristic at a target region, such as the blood-brain barrier, include causing an ultrasound transducer to transmit acoustic energy to the target region at a transmission frequency; acquiring a cumulative harmonic response from at least the target region; and operating the transducer based at least in part on the acquired cumulative harmonic response.Type: ApplicationFiled: March 1, 2023Publication date: June 29, 2023Inventors: Yoav Levy, Eyal Zadicario, Javier Grinfeld, Rafi De Picciotto, Michael Plaksin, Avinoam Bar-Zion
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Patent number: 11358007Abstract: Various approaches for enhancing treatment of target tissue using a source of focused ultrasound while limiting damage to non-target tissue include selecting a frequency of ultrasound waves transmitted from the source of focused ultrasound for generating a focus in the target tissue; providing microbubbles having the first size distribution such that at least 50% of the microbubbles have a radius smaller than a critical radius corresponding to a resonance frequency matching the selected frequency of ultrasound waves; and applying the ultrasound waves at the selected frequency to treat the target tissue.Type: GrantFiled: June 29, 2018Date of Patent: June 14, 2022Assignee: INSIGHTEN, LTD.Inventors: Rafi De Picciotto, Javier Grinfeld, Yoav Levy
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Publication number: 20210204915Abstract: Various approaches for generating an ultrasound focus at a target region and receiving signals therefrom using an ultrasound transducer having multiple transducer elements include acquiring multiple images of the target region and one or more path zones located on beam paths between the transducer elements and the target region; determining one or more tissue characteristics associated with the target region based on the acquired images; determining multiple profile parameters associated with each of the transducer elements based at least in part on the determined tissue characteristic; based at least in part on the profile parameters, operating at least first ones of the transducer elements to collectively transmit an ultrasound beam to the target region so as to create a focus thereon with desired properties; and based at least in part on the profile parameters, operating at least second ones of the transducer elements to receive acoustic signals from the target region and, in response thereto, adjusting opType: ApplicationFiled: June 4, 2019Publication date: July 8, 2021Inventors: Kobi VORTMAN, Rafi DE PICCIOTTO
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Publication number: 20210146156Abstract: Various approaches for enhancing treatment of target tissue using a source of focused ultrasound while limiting damage to non-target tissue include selecting a frequency of ultrasound waves transmitted from the source of focused ultrasound for generating a focus in the target tissue; providing microbubbles having the first size distribution such that at least 50% of the microbubbles have a radius smaller than a critical radius corresponding to a resonance frequency matching the selected frequency of ultrasound waves; and applying the ultrasound waves at the selected frequency to treat the target tissue.Type: ApplicationFiled: June 29, 2018Publication date: May 20, 2021Inventors: Rafi DE PICCIOTTO, Javier GRINFELD, Yoav LEVY
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Publication number: 20200171327Abstract: Various approaches for computationally generating a protocol for treatment of one or more target BBB regions within a tissue region of interest using a source of focused ultrasound include specifying (i) settings of sonication parameters for applying one or more sequence of sonications to the target BBB region using the source of focused ultrasound and (ii) a characteristic of microbubbles selected to be administered into the target BBB region; electronically simulating treatment in accordance with the protocol at least in part by computationally executing the sequence(s) of sonications and computationally administering the microbubbles having the characteristic; and computationally predicting a tissue disruption effect of the target BBB region resulting from the treatment.Type: ApplicationFiled: June 29, 2018Publication date: June 4, 2020Inventors: Yoav LEVY, Rafi DE PICCIOTTO, Javier GRINFELD, Eyal ZADICARIO
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Publication number: 20200139158Abstract: Systems and methods for applying ultrasound sonication to temporarily disrupt a patient's blood-brain barrier (BBB) include storing threshold values of an acoustic response level, an acoustic response dose and a tissue response dose associated with a target BBB region and its surrounding regions based on anatomical characteristics thereof; causing the ultrasound transducer to transmit one or more pulses/waves; measuring the acoustic response level, the acoustic response dose, and/or the tissue response dose associated with the target BBB region and/or its surrounding regions; comparing the measurement with a corresponding stored threshold value; and operating the transducer based at least in part on the comparison.Type: ApplicationFiled: May 22, 2018Publication date: May 7, 2020Inventors: Yoav LEVY, Eyal ZADICARIO, Javier GRINFELD, Rafi DE PICCIOTTO
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Patent number: 9466458Abstract: A scanning electron microscope suitable for imaging samples in a non-vacuum environment, the scanning electron microscope including an electron source located within an enclosure maintained under vacuum, an electron permeable membrane disposed at an opening of the enclosure separating an environment within the enclosure which is maintained under vacuum and an environment outside the enclosure which is not maintained under vacuum, the electron permeable membrane not being electrically grounded and at least one non-grounded electrode operative as an electron detector.Type: GrantFiled: February 18, 2014Date of Patent: October 11, 2016Assignee: B-NANO LTD.Inventors: Dov Shachal, Rafi De Picciotto
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Patent number: 9431213Abstract: An interface, a scanning electron microscope and a method for observing an object that is positioned in a non-vacuum environment. The method includes: generating an electron beam in the vacuum environment; scanning a region of the object with the electron beam while the object is located below an object holder; wherein the scanning comprises allowing the electron beam to pass through an aperture of an aperture array, pass through an ultra thin membrane that seals the aperture, and pass through the object holder; wherein the ultra thin membrane withstands a pressure difference between the vacuum environment and the non-vacuum environment; and detecting particles generated in response to an interaction between the electron beam and the object.Type: GrantFiled: February 5, 2015Date of Patent: August 30, 2016Assignee: B-NANO LTD.Inventors: Dov Shachal, Rafi De Picciotto
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Publication number: 20150380207Abstract: A scanning electron microscope suitable for imaging samples in a non-vacuum environment, the scanning electron microscope including an electron source located within an enclosure maintained under vacuum, an electron permeable membrane disposed at an opening of the enclosure separating an environment within the enclosure which is maintained under vacuum and an environment outside the enclosure which is not maintained under vacuum, the electron permeable membrane not being electrically grounded and at least one non-grounded electrode operative as an electron detector.Type: ApplicationFiled: February 18, 2014Publication date: December 31, 2015Applicant: B-NANO LTD.Inventors: Dov SHACHAL, Rafi DE PICCIOTTO
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Publication number: 20150243475Abstract: An interface, a scanning electron microscope and a method for observing an object that is positioned in a non-vacuum environment. The method includes: generating an electron beam in the vacuum environment; scanning a region of the object with the electron beam while the object is located below an object holder; wherein the scanning comprises allowing the electron beam to pass through an aperture of an aperture array, pass through an ultra thin membrane that seals the aperture, and pass through the object holder; wherein the ultra thin membrane withstands a pressure difference between the vacuum environment and the non-vacuum environment; and detecting particles generated in response to an interaction between the electron beam and the object.Type: ApplicationFiled: February 5, 2015Publication date: August 27, 2015Applicant: B-NANO LTD.Inventors: Dov SHACHAL, Rafi DE PICCIOTTO
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Patent number: 8981294Abstract: An interface, a scanning electron microscope and a method for observing an object that is positioned in a non-vacuum environment. The method includes: generating an electron beam in the vacuum environment; scanning a region of the object with the electron beam while the object is located below an object holder; wherein the scanning comprises allowing the electron beam to pass through an aperture of an aperture array, pass through an ultra thin membrane that seals the aperture, and pass through the object holder; wherein the ultra thin membrane withstands a pressure difference between the vacuum environment and the non-vacuum environment; and detecting particles generated in response to an interaction between the electron beam and the object.Type: GrantFiled: October 30, 2012Date of Patent: March 17, 2015Assignee: B-Nano Ltd.Inventors: Dov Shachal, Rafi De Picciotto
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Publication number: 20140117232Abstract: An interface, a scanning electron microscope and a method for observing an object that is positioned in a non-vacuum environment. The method includes: generating an electron beam in the vacuum environment; scanning a region of the object with the electron beam while the object is located below an object holder; wherein the scanning comprises allowing the electron beam to pass through an aperture of an aperture array, pass through an ultra thin membrane that seals the aperture, and pass through the object holder; wherein the ultra thin membrane withstands a pressure difference between the vacuum environment and the non-vacuum environment; and detecting particles generated in response to an interaction between the electron beam and the object.Type: ApplicationFiled: October 30, 2012Publication date: May 1, 2014Applicant: B-NANO LTD.Inventors: Dov SHACHAL, Rafi DE PICCIOTTO
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Patent number: 8492716Abstract: A vacuumed device that includes: a sealed housing, an electron beam source, an electron optic component, a thin membrane, and a detector. The thin membrane seals an aperture of the sealed housing. The sealed housing defines a vacuumed space in which vacuum is maintained. The electron beam source is configured to generate an electron beam that propagates within the vacuumed space, interacts with the electron optic component and passes through the thin membrane. A first portion of the sealed housing is shaped to fit a space defined by non-vacuumed scanning electron microscope components that are maintained in a non-vacuum environment.Type: GrantFiled: September 24, 2009Date of Patent: July 23, 2013Assignee: B-Nano Ltd.Inventors: Dov Shachal, Rafi De Picciotto
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Patent number: 8334510Abstract: An interface, a scanning electron microscope and a method for observing an object that is positioned in a non-vacuum environment. The method includes: generating an electron beam in the vacuum environment; scanning a region of the object with the electron beam while the object is located below an object holder; wherein the scanning comprises allowing the electron beam to pass through an aperture of an aperture array, pass through an ultra thin membrane that seals the aperture, and pass through the object holder; wherein the ultra thin membrane withstands a pressure difference between the vacuum environment and the non-vacuum environment; and detecting particles generated in response to an interaction between the electron beam and the object.Type: GrantFiled: July 2, 2009Date of Patent: December 18, 2012Assignee: B-Nano Ltd.Inventors: Dov Shachal, Rafi De Picciotto
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Publication number: 20110210247Abstract: A vacuumed device that includes: a sealed housing, an electron beam source, an electron optic component, a thin membrane, and a detector. The thin membrane seals an aperture of the sealed housing. The sealed housing defines a vacuumed space in which vacuum is maintained. The electron beam source is configured to generate an electron beam that propagates within the vacuumed space, interacts with the electron optic component and passes through the thin membrane. A first portion of the sealed housing is shaped to fit a space defined by non-vacuumed scanning electron microscope components that are maintained in a non-vacuum environment.Type: ApplicationFiled: September 24, 2009Publication date: September 1, 2011Applicant: B-NANO LTD.Inventors: Dov Shachal, Rafi De picciotto
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Publication number: 20110168889Abstract: An interface, a scanning electron microscope and a method for observing an object that is positioned in a non-vacuum environment. The method includes: generating an electron beam in the vacuum environment; scanning a region of the object with the electron beam while the object is located below an object holder; wherein the scanning comprises allowing the electron beam to pass through an aperture of an aperture array, pass through an ultra thin membrane that seals the aperture, and pass through the object holder; wherein the ultra thin membrane withstands a pressure difference between the vacuum environment and the non-vacuum environment; and detecting particles generated in response to an interaction between the electron beam and the object.Type: ApplicationFiled: July 2, 2009Publication date: July 14, 2011Inventors: Dov Shachal, Rafi De Picciotto