Patents by Inventor Rafick-Pierre Sekaly

Rafick-Pierre Sekaly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20030228586
    Abstract: The present invention relates to a method for measuring de novo T-cell production in humans, and more particularly to the assessement recent thymic emigrant (RTE) diversity in a T-cell sub-population of a patient by the detection of T-cell receptor &bgr; chain DNA deletion circles (TCR&bgr;DC) generated during TCR gene rearrangement of thymocytes in the thymus. The method comprises isolating a T-cell sub-population from a patient, extracting genomic DNA from the T-cell sub-population, amplifying the genomic DNA with a primer specific for a T-cell receptor &bgr; chain DNA rearrangement deletion circle (TCR&bgr;DC) family and detecting the TCR&bgr;DC, the TRC&bgr;DC being indicative of the presence of a RTE. The method assesses the quantitative and qualitative (diversity) intrathymic T-cell production by quantitating the relative frequency and diversity of RTEs within various sub-populations of circulating human T-cells.
    Type: Application
    Filed: January 13, 2003
    Publication date: December 11, 2003
    Inventors: Rafick-Pierre Sekaly, Jean-Francois Poulin, Morgan Jenkins, Jeffrey M. Harris, Krishna V. Komanduri, Joseph M. McCune