Patents by Inventor Rafik Naccache

Rafik Naccache has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and system for determination of photothermal properties of particles
    Patent number: 11360022
    Abstract: A method and a system for determining material-, size-, and morphology-dependent photothermal properties of particles dispersed in solutions, the method comprising using coherently detected pulsed THz radiation, tracking a temperature-dependent refractive index change of the particles dispersion in time and space, and correlating the temperature-dependent refractive index change of the particles dispersion in time and space to temperature values. A system comprises a source of electromagnetic radiation; a THz emitter; a THz detector; and a vessel containing a dispersion of particles, wherein the source of electromagnetic radiation is configured to emit electromagnetic radiation to excite the particles in the dispersion; the THz emitter is configured to send THz radiation to the vessel and the THz detector is configured to receives THz radiation returned by from the vessel.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: June 14, 2022
    Inventors: Holger Breitenborn, Junliang Dong, Riccardo Piccoli, Roberto Morandotti, Luca Razzari, Rafik Naccache, Fiorenzo Vetrone
  • METHOD AND SYSTEM FOR DETERMINATION OF PHOTOTHERMAL PROPERTIES OF PARTICLES
    Publication number: 20210025816
    Abstract: A method and a system for determining material-, size-, and morphology-dependent photothermal properties of particles dispersed in solutions, the method comprising using coherently detected pulsed THz radiation, tracking a temperature-dependent refractive index change of the particles dispersion in time and space, and correlating the temperature-dependent refractive index change of the particles dispersion in time and space to temperature values. A system comprises a source of electromagnetic radiation; a THz emitter; a THz detector; and a vessel containing a dispersion of particles, wherein the source of electromagnetic radiation is configured to emit electromagnetic radiation to excite the particles in the dispersion; the THz emitter is configured to send THz radiation to the vessel and the THz detector is configured to receives THz radiation returned by from the vessel.
    Type: Application
    Filed: July 24, 2020
    Publication date: January 28, 2021
    Inventors: Holger Breitenborn, Junliang Dong, Riccardo Piccoli, Roberto Morandotti, Luca Razzari, Rafik Naccache, Fiorenzo Vetrone
  • Alternative forms of the phosphodiesterase-4 inhibitor N-cyclopropyl-1-{3-[(1-oxidopryidin-3-yl)ethynyl]phenyl}-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxyamide
    Patent number: 8552193
    Abstract: The present invention is directed to alternative forms of the title phosphodiesterase 4 inhibitor which has the structural formula shown immediately below:
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: October 8, 2013
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Sophie-Dorothee Clas, Rafik Naccache, Hongshi Yu, Jerry Murry, Narayan Vanankaval
  • ALTERNATIVE FORMS OF THE PHOSPHODIESTERASE-4 INHIBITOR N-CYCLOPROPYL-1--4-OXO-1,4-DIHYDRO-1,8-NAPHTHYRIDINE-3-CARBOXYAMIDE
    Publication number: 20130231363
    Abstract: The present invention is directed to alternative forms of the title phosphodiesterase 4 inhibitor which has the structural formula shown immediately below:
    Type: Application
    Filed: March 31, 2010
    Publication date: September 5, 2013
    Inventors: Sophie-Dorothee Clas, Rafik Naccache, Hongshi Yu, Jerry Murry, Narayan Variankaval
  • Alternative Forms of the Phosphodiesterase-4 Inhibitor N-Cyclopropyl-1--4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-Carboxyamide
    Publication number: 20110245290
    Abstract: The present invention is directed to alternative forms of the title phosphodiesterase 4 inhibitor which has the structural formula shown immediately below:
    Type: Application
    Filed: March 31, 2010
    Publication date: October 6, 2011
    Inventors: Sophie-Dorothee Clas, Rafik Naccache, Hongshi Yu, Jerry Murry, Narayan Variankaval
  • PROCESS FOR MAKING GLUCOCORTICOID RECEPTOR LIGANDS
    Publication number: 20100228036
    Abstract: The invention encompasses a process for making 2-[1-phenyl-5-hydroxy-4alpha-methyl-hexahydrocyclopenta[f]indazol-5-yl]ethyl phenyl derivatives, which are glucocorticoid receptor ligands, useful for the treatment of inflammatory and immunological diseases.
    Type: Application
    Filed: October 20, 2008
    Publication date: September 9, 2010
    Inventors: Qinghao Chen, Shinji Fujimori, Jacob M. Janey, John Limanto, Rafik Naccache, Andrew F. Nolting, Zhigou J. Song, Neil Strotman, Lushi Tan, Mark Weisel
  • Altenrative Forms Of The Phosphodeisterase -4 Inhibitor N-Cyclopropyl-1- -3{3-[(1-Oxidopyryidin-3-Yl) Phenyl]-4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-Carboxyamide
    Publication number: 20080119509
    Abstract: The present invention is directed to alternative forms of the title phosphodiesterase 4 inhibitor which has the structural formula shown immediately below: Compound IX
    Type: Application
    Filed: April 22, 2005
    Publication date: May 22, 2008
    Inventors: Sophie-Dorothee Clas, Rafik Naccache, Hongshi Yu, Jerry Murry, Narayan Variankaval