Patents by Inventor Rafiuddin

Rafiuddin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline bortezomib process
    Patent number: 9217001
    Abstract: The present invention provides process for preparation of crystalline Bortezomib (Ia) as its monohydrate which is designated as crystalline Form-SB and characterized by having water content ranging between 3.5-6.0% w/w; X-ray powder diffraction pattern comprising characteristic 2?° peaks selected from the XRPD peak set of 5.6, 7.5, 9.8, 10.2, 11.3, 15.1, 18.0, 20.5, 21.5 and 23.6±0.20 2?°, wherein peaks at 9.8 and 11.39±0.20 2?° are un-split and 100% intensity peak is present at 5.6±0.20 2?°, DSC isotherm comprising the endothermic peaks ranging between 45 to 60° C. (Peak-1) and 175 to 185° C. (Peak-2) and IR absorption characteristic peaks approximately at 3387 cm?1, 3304 cm?1, 2953 cm?1, 2927 cm?1, 2868 cm?1, 1627 cm?1, 1455 cm?1, 1400 cm?1, 1201 cm?1, 1150 cm?1, 1020 cm?1, 747 cm?1 and 702 cm?1 and Raman absorption spectra having characteristic peaks approximately at 3066 cm?1, 1583 cm?1, 1528 cm?1, 1281 cm?1, 1213 cm?1, 1035 cm?1, 1022 cm?1 and 1004 cm?1.
    Type: Grant
    Filed: November 12, 2013
    Date of Patent: December 22, 2015
    Assignee: SHILPA MEDICARE LIMITED
    Inventors: Vimal Kumar Shrawat, Rafiuddin, Vinod Kumar Singh, Akshay Kant Chaturvedi
  • Process for preparing bicalutamide
    Patent number: 8895772
    Abstract: The present invention provide processes for the preparation of N-[4-Cyano-3-(trifluoro methyl)phenyl]-3-[(4-fluorophenyl)sulphonyl]-2-hydroxy-2-methyl propanamide (I). The present application also provides a method of purification of N-[4-Cyano-3-(trifluoro methyl)phenyl]-3-[(4-fluorophenyl)sulphonyl]-2-hydroxy-2-methyl propanamide (I) using ethyl acetate solvent resulting in the product, substantially free from process related impurities A, B, C and D. The crystalline product of the process according to the present invention having an XRDP pattern as per FIG. 1, is useful as an active pharmaceutical and has anti-androgenic activity.
    Type: Grant
    Filed: August 29, 2011
    Date of Patent: November 25, 2014
    Assignee: Shilpa Medicare Limited
    Inventors: Vimal Kumar Shrawat, Karri Papa Rao, Rafiuddin, Prashant Purohit
  • Process for preparing docetaxel and its hydrate
    Patent number: 8829210
    Abstract: The present invention provide process of preparation of (2R,3S)—N-carboxy-3-phenylisoserine, N-tert-butyl ester, 13-ester with 5(?)-20-epoxy-1,2(?),4,7(?),10(?),13(?)-hexa hydroxy tax-11-en-9-one 4-acetate 2-benzoate or docetaxel and its trihydrate (I)
    Type: Grant
    Filed: August 29, 2011
    Date of Patent: September 9, 2014
    Assignee: Shilpa Medicare Limited
    Inventors: Vimal Kumar Shrawat, Rafiuddin, Veereshappa, Prashant Purohit
  • PROCESS FOR PREPARING DOCETAXEL AND ITS HYDRATE
    Publication number: 20140039209
    Abstract: The present invention provide process of preparation of (2R,3S)—N-carboxy-3-phenylisoserine, N-tert-butyl ester, 13-ester with 5(?)-20-epoxy-1,2(?),4,7(?),10(?),13(?)-hexa hydroxy tax-11-en-9-one 4-acetate 2-benzoate or docetaxel and its trihydrate (I)
    Type: Application
    Filed: August 29, 2011
    Publication date: February 6, 2014
    Inventors: Vimal Kumar Shrawat, Rafiuddin, Prashant Purohit