Abstract: The invention discloses a LSPR based label free immunosensing technique using a fiber optic system (100) for detecting an analyte molecule in a sample. The invention further discloses a U-shaped plasmonic optic fiber probe biosensor (200) to detect ochratoxin-A (OTA) in a sample and a method (300) of fabrication thereof. The optic fiber probe (101) biosensor (200) includes a sensing layer (205), a light source (102) to send light through the probe (101) and an optical detector (103) to detect a change in optical intensity due to a change in the localized surface plasmon resonance (LSPR) caused by binding of the analyte molecule to the antibody encapsulated in a metal organic framework. The antibody (204) in the sensing layer (205) is specific to the analyte molecule and configured to form an immunocomplex therewith.

Abstract: The disclosure provides methods of detecting a cannabinoid or metabolite thereof in a sample and test kits for the same. For example, the cannabinoid such as tetrahydrocannabinol (THC) bound to bovine serum albumin (BSA) may induce changes in optical properties of an optical biosensor employed for the said detection wherein the optical biosensor is immobilized with a suitable bioreceptor or through interactions with a bioreceptor-nanoparticle conjugate.

Abstract: The disclosure proposes a portable fiber optic measurement device (100) for physical, chemical, and biological sensing applications that facilitates real-time monitoring. The device (100) includes a fiber optic probe cartridge (120) that is removably attached to a measuring device (110). The device (110) includes a light source, a detector, and the associated electronic measurement and control unit along with a display. The device (100) is configured to measure the real-time changes in the light intensity on the fiber probe cartridge side (130). With a U-bent fiber optic probe cartridge (138) as an example, the device (100) is configured to measure the bulk solution refractive index changes, effective refractive index change, or characteristic optical property of analytes including ions, chemical and bio molecules, polymers, compounds, microorganisms present on the fiber core surface (138).

Abstract: The invention discloses an apparatus (100) to fabricate U-bent fiber optic sensors, transducers and waveguides, using laser assisted technologies as heat source. The apparatus includes a heating source (110) and a robotic articulate arm (130) that may modify the geometry of an optical fiber (150) with either silica or polymer cladding and fabricate sensor probes by decladding the polymeric cladding in addition to twisting and bending of the optical fiber in an automated manner. The geometry of the optical fiber sensor probe is controlled by the heating source (110), beam (112) thickness, exposure time of fiber and the positioning of a motorized stage. The advantage of the apparatus includes reduction in fabrication time, repeatable and controllable bend diameter for any size of optic fiber probes.

Abstract: A biosensor having an optical fiber having at least one curved portion configured to enhance penetration of evanescent waves; and one or more nanoparticles associated with the optical fiber, and configured to enhance localized surface plasmon resonance.

Abstract: A biosensor having an optical fiber having at least one curved portion configured to enhance penetration of evanescent waves; and one or more nanoparticles associated with the optical fiber, and configured to enhance localized surface plasmon resonance.

Abstract: A biosensor having an optical fiber having at least one curved portion configured to enhance penetration of evanescent waves; and one or more nanoparticles associated with the optical fiber, and configured to enhance localized surface plasmon resonance.