Abstract: Systems and methods are provided for synchronizing a bistatic inverse synthetic aperture radar (ISAR) imaging radar system using only the signal that travels directly between the transmitter and receiver. In an embodiment, an extracted direct path signal is used as a matched filter reference function. In an embodiment, full pulse compression is used for a matched filter implementation. Embodiments of the present disclosure provide systems and methods for detecting and extracting the direct path signal and using this direct path signal to synchronize the received signal stream in a bistatic ISAR system.

Abstract: The invention provides an ocular composition comprising: 99 to 60% (w/w) of a photopolymerizable composition selected from the group of fragments or monomers consisting of polyalkylene glycol diacrylate and polyalkylene glycol dimethacrylate, wherein the photopolymerizable composition has a molecular weight in the range of 100 to 20,000 Dalton; a biodegradable polymer selected from the group consisting of aliphatic polyester-based polyurethanes, polylactides, polycaprolactones, polyorthoesters and mixtures, copolymers, and block copolymers thereof; a photoinitiator; and a therapeutic agent. The composition can be used to form an ocular implant and an in situ ocular implant.

Abstract: The present invention relates to an ocular composition comprising a) at least 0.1% w/w of a therapeutic agent; b) 5 to 95% w/w of a photopolymerizable composition comprising 3 to 70% w/w of one or more compounds of formula I: (I) wherein R1 is hydrogen or a linear or branched C1-C3 alkyl; R2 is an acrylate or methacrylate group; n is 2 or 3 and m is equal or greater than 1, the weight percentage of the one or more compounds of formula I being based on the total weight of the photopolymerizable composition; c) 0.

Abstract: A composite implant for sustained release of a therapeutic agent in an ocular area of a subject. The composite implant comprises a matrix of photopolymerized polymer formed from a photopolymerizable composition, a biodegradable polymer contained within the matrix, and a therapeutic agent dispersed or dissolved between the matrix and/or biodegradable polymer, wherein the implant is formed from an ocular composition comprising 99 to 60% (w/w) of the photopolymerizable composition. The composite implant can be used in methods of delivering a therapeutic agent to an ocular area in a subject in need thereof, particularly by injecting the implant into the ocular area. Methods of preparing the composite implant are also disclosed.

Abstract: The invention provides methods of making microparticle and nanoparticle ocular implants from a compositions comprising: 99 to 60% (w/w) of a photopolymerizable composition selected from the group of fragments or monomers consisting of polyalkylene glycol diacrylate and polyalkylene glycol dimethacrylate, wherein the photopolymerizable composition has a molecular weight in the range of 100 to 20,000 Dalton; a biodegradable polymer selected from the group consisting of aliphatic polyester-based polyurethanes, polylactides, polycaprolactones, polyorthoesters and mixtures, copolymers, and block copolymers thereof; a photoinitiator; and a therapeutic agent.

Abstract: The present invention relates to ocular compositions for the controlled release of a therapeutic agent. The ocular composition comprises at least 20% w/w of a therapeutic agent; 5 to 75% w/w of a photopolymerizable composition selected from the group consisting of fragments or monomers of polyalkylene glycol mono-acrylate, polyalkylene glycol diacrylate, polyalkylene glycol methacrylate and polyalkylene glycol dimethacrylate, and mixtures, copolymers, and block copolymers thereof; 0.1 to 40% w/w of a biodegradable polymer selected from the group consisting of lactide/glycolide copolymer (including poly(lactide-co-glycolide) (PLGA)), poly (L-lactide) (PLA), polyhydroxyalkanoates, including polyhydroxybutyrate, polyglycolic acid (PGA), polycaprolactone (PCL), poly (DL-lactide) (PDL), poly (D-lactide), lactide/caprolactone copolymer, poly-L-lactide-co-caprolactone (PLC) and mixtures, copolymers, and block copolymers thereof; and a photoinitiator.

Abstract: The present invention relates to an ocular implant for the controlled release of a therapeutic agent or drug comprising: a) at least 0.1% w/w of a therapeutic agent; b) 5 to 95% w/w of a crosslinked polymer matrix; c) and 0.

Abstract: The invention provides methods of making microparticle and nanoparticle ocular implants from a compositions comprising: 99 to 60% (w/w) of a photopolymerizable composition selected from the group of fragments or monomers consisting of polyalkylene glycol diacrylate and polyalkylene glycol dimethacrylate, wherein the photopolymerizable composition has a molecular weight in the range of 100 to 20,000 Dalton; a biodegradable polymer selected from the group consisting of aliphatic polyester-based polyurethanes, polylactides, polycaprolactones, polyorthoesters and mixtures, copolymers, and block copolymers thereof; a photoinitiator; and a therapeutic agent.

Abstract: The invention provides an ocular composition comprising: 99 to 60% (w/w) of a photopolymerizable composition selected from the group of fragments or monomers consisting of polyalkylene glycol diacrylate and polyalkylene glycol dimethacrylate, wherein the photopolymerizable composition has a molecular weight in the range of 100 to 20,000 Dalton; a biodegradable polymer selected from the group consisting of aliphatic polyester-based polyurethanes, polylactides, polycaprolactones, polyorthoesters and mixtures, copolymers, and block copolymers thereof; a photoinitiator; and a therapeutic agent. The composition can be used to form an ocular implant and an in situ ocular implant.

Abstract: One embodiment of the present invention relates to noise control of one or more signals. In one embodiment, impulsive-type noise events, such as multipath noise events or pops, may be detected and suppressed to reduce signal distortion. For example, in one embodiment related to a radio receiver (100), a predictor (436) having an adaptive filter (402) is used in combination with a fast attack slow decay mechanism (434) to provide noise control signals (352, 358) which may then be used to suppress noise events. In one embodiment, the fast attack slow decay mechanism includes applying a wide bandwidth filter at the onset of a noise event to quickly track variations in an error signal and applying a narrow wide bandwidth filter a peak of the noise event is detected in order to smooth variations in the error signal (410). This allows for improved psycho-acoustic perception. In one embodiment, the radio receiver is a mobile radio receiver.

Abstract: Embodiments of the present invention relate generally to receivers. A frequency modulated (FM) receiver includes an equalizer control unit coupled to receive at least one FM signal quality indicator and provide a control signal based on the FM signal quality indicator. An adaptive equalizer coupled to receive the control signal from the equalizer control unit and an FM signal and provide a filtered FM signal corresponding to the received FM signal. Coefficients of the adaptive equalizer are reset in response to the control signal. Another embodiment relates to a method for processing a frequency modulated (FM) signal. An FM signal is received. At least one FM signal quality indicator is used to provide a control signal. Based on the control signal, the received FM signal is filtered using one of an adaptive filter and a static filter to provide a filtered FM signal.

Abstract: One embodiment of the present invention relates to noise control of one or more signals. In one embodiment, impulsive-type noise events, such as multipath noise events or pops, may be detected and suppressed to reduce signal distortion. For example, in one embodiment related to a radio receiver (100), a predictor (436) having an adaptive filter (402) is used in combination with a fast attack slow decay mechanism (434) to provide noise control signals (352, 358) which may then be used to suppress noise events. In one embodiment, the fast attack slow decay mechanism includes applying a wide bandwidth filter at the onset of a noise event to quickly track variations in an error signal and applying a narrow wide bandwidth filter a peak of the noise event is detected in order to smooth variations in the error signal (410). This allows for improved psycho-acoustic perception. In one embodiment, the radio receiver is a mobile radio receiver.