Patents by Inventor Raghuram Tangirala

Raghuram Tangirala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5-membered and bicyclic heterocyclic amides as inhibitors of ROCK
    Patent number: 11673886
    Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
    Type: Grant
    Filed: June 17, 2021
    Date of Patent: June 13, 2023
    Assignee: Bristol-Myers Squibb Company
    Inventors: Peter W. Glunz, Vladimir Ladziata, Indawati De Lucca, George O. Tora, Tarun Kumar Maishal, Raghuram Tangirala, Kamalraj Thiyagarajan
  • HETEROCYCLIC COMPOUNDS AS MODULATORS OF STIMULATOR OF INTERFERON GENES (STING)
    Publication number: 20230076506
    Abstract: The present invention relates to compounds of formula (I) and salts, stereoisomers, tautomers or N-oxides thereof that are useful as modulators of STING (Stimulator of Interferon Genes). The present invention further relates to the compounds of formula (I) for use as a medicament and to a pharmaceutical composition comprising said compounds.
    Type: Application
    Filed: December 11, 2020
    Publication date: March 9, 2023
    Applicant: RYVU THERAPEUTICS S.A.
    Inventors: Magdalena Izabela ZAWADZKA, Luigi Piero STASI, Maciej Krzysztof ROGACKI, Grzegorz Wojciech CWIERTNIA, Lukasz Piotr DUDEK, Agnieszka Justyna GIBAS, Anna RAJDA, Charles-Henry FABRITIUS, Adam RADZIMIERSKI, Tushar Ravindra MAHAJAN, Marcin Wojciech LES, Karol ZUCHOWICZ, Marek WRONOWSKI, David Jörg SYNAK, Sundara Raghuram TANGIRALA
  • FUNCTIONALIZED HETEROCYCLIC COMPOUNDS AS MODULATORS OF STIMULATOR OF INTERFERON GENES (STING)
    Publication number: 20230055741
    Abstract: The present invention relates to compound-linker constructs and antibody-drug-conjugates of compounds of formula (I) that are useful as modulators of STING (Stimulator of Interferon Genes).
    Type: Application
    Filed: December 11, 2020
    Publication date: February 23, 2023
    Applicant: RYVU THERAPEUTICS S.A.
    Inventors: Magdalena Izabela ZAWADZKA, Luigi Piero STASI, Maciej Krzysztof ROGACKI, Grzegorz Wojciech CWIERTNIA, Lukasz Piotr DUDEK, Agnieszka Justyna GIBAS, Anna RAJDA, Charles-Henry FABRITIUS, Adam RADZIMIERSKI, Tushar Ravindra MAHAJAN, Marcin Wojciech LES, Karol ZUCHOWICZ, Marek WRONOWSKI, David Jörg SYNAK, Sundara Raghuram TANGIRALA
  • 5-MEMBERED AND BICYCLIC HETEROCYCLIC AMIDES AS INHIBITORS OF ROCK
    Publication number: 20220356179
    Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
    Type: Application
    Filed: June 17, 2021
    Publication date: November 10, 2022
    Inventors: Peter W. Glunz, Vladimir Ladziata, Indawati De Lucca, George O. Tora, Tarun Kumar Maishal, Raghuram Tangirala, Kamalraj Thiyagarajan
  • 5-membered and bicyclic heterocyclic amides as inhibitors of rock
    Patent number: 11078197
    Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: August 3, 2021
    Assignee: Bristol-Myers Squibb Company
    Inventors: Peter W. Glunz, Vladimir Ladziata, Indawati De Lucca, George O. Tora, Tarun Kumar Maishal, Raghuram Tangirala, Kamalraj Thiyagarajan
  • 5-MEMBERED AND BICYCLIC HETEROCYCLIC AMIDES AS INHIBITORS OF ROCK
    Publication number: 20210147406
    Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
    Type: Application
    Filed: July 11, 2018
    Publication date: May 20, 2021
    Inventors: Peter W. Glunz, Vladimir Ladziata, Indawati De Lucca, George O. Tora, Tarun Kumar Maishal, Raghuram Tangirala, Kamalraj Thiyagarajan
  • Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
    Patent number: 10681908
    Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing such molecules, and processes of using such molecules and compositions against such pests. These molecules and compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: June 16, 2020
    Assignee: DOW AGROSCIENCES LLC
    Inventors: Thomas Barton, Xin Gao, Jim Hunter, Paul R. LePlae, Jr., William C. Lo, Joshodeep Boruwa, Raghuram Tangirala, Gerald B. Watson, John Herbert
  • Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
    Patent number: 10638756
    Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: May 5, 2020
    Assignee: DOW AGROSCIENCES LLC
    Inventors: Paul R. LePlae, Jr., Thomas Barton, Xin Gao, James E. Hunter, William C. Lo, Joshodeep Boruwa, Raghuram Tangirala, Gerald B. Watson, John Herbert, David A. Demeter, Hemant Joshi
  • Compounds as diacylglycerol acyltransferase inhibitors
    Patent number: 10385066
    Abstract: This invention relates to methods for the preparation of a compound which is an inhibitor of acyl coenzyme A: diacylglycerol acyltransferase 1 (DGAT-1).
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: August 20, 2019
    Assignee: GlaxoSmithKline LLC
    Inventors: Mui Cheung, Raghuram Tangirala
  • NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS
    Publication number: 20190135829
    Abstract: This invention relates to methods for the preparation of a compound which is an inhibitor of acyl coenzyme A: diacylglycerol acyltransferase 1 (DGAT-1).
    Type: Application
    Filed: January 4, 2019
    Publication date: May 9, 2019
    Applicant: GlaxoSmithKline LLC
    Inventors: Mui Cheung, Raghuram Tangirala
  • Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
    Patent number: 10251394
    Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing such molecules, and processes of using such molecules and compositions against such pests. These molecules and compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: April 9, 2019
    Assignee: Dow AgroSciences LLC
    Inventors: Thomas Barton, Xin Gao, Jim Hunter, Paul R. LePlae, Jr., William C. Lo, Joshodeep Boruwa, Raghuram Tangirala, Gerald B. Watson, John Herbert
  • Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
    Publication number: 20180279612
    Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
    Type: Application
    Filed: March 29, 2018
    Publication date: October 4, 2018
    Applicant: Dow AgroSciences LLC
    Inventors: Paul R. LePlae, JR., Thomas Barton, Xin Gao, James E. Hunter, William C. Lo, Joshodeep Boruwa, Raghuram Tangirala, Gerald B. Watson, John Herbert, David A. Demeter, Hemant Joshi
  • Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
    Patent number: 9930892
    Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing such molecules, and processes of using such molecules and compositions against such pests. These molecules and compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: April 3, 2018
    Assignee: Dow AgroSciences LLC
    Inventors: Thomas Barton, Xin Gao, Jim Hunter, Paul R. LePlae, Jr., William C. Lo, Joshodeep Boruwa, Raghuram Tangirala, Gerald B. Watson, John Herbert
  • Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
    Patent number: 9924717
    Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing such molecules, and processes of using such molecules and compositions against such pests. These molecules and compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: March 27, 2018
    Assignee: Dow AgroSciences LLC
    Inventors: Thomas Barton, Xin Gao, Jim Hunter, Paul R. LePlae, Jr., Lori K. Lawler, William C. Lo, Jeff Petkus, Joshodeep Boruwa, Raghuram Tangirala, Gerald B. Watson, John Herbert
  • Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
    Patent number: 9924716
    Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing such molecules, and processes of using such molecules and compositions against such pests. These molecules and compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: March 27, 2018
    Assignee: Dow AgroSciences LLC
    Inventors: Thomas Barton, Xin Gao, Jim Hunter, Paul R. LePlae, Jr., William C. Lo, Joshodeep Boruwa, Raghuram Tangirala, Gerald B. Watson, John Herbert
  • MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO
    Publication number: 20170208810
    Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing such molecules, and processes of using such molecules and compositions against such pests. These molecules and compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
    Type: Application
    Filed: January 18, 2017
    Publication date: July 27, 2017
    Applicant: Dow AgroSciences LLC
    Inventors: Thomas Barton, Xin Gao, Jim Hunter, Paul R. LePlae, JR., William C. Lo, Joshodeep Boruwa, Raghuram Tangirala, Gerald B. Watson, John Herbert
  • MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO
    Publication number: 20170208806
    Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing such molecules, and processes of using such molecules and compositions against such pests. These molecules and compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
    Type: Application
    Filed: January 18, 2017
    Publication date: July 27, 2017
    Applicant: Dow AgroSciences LLC
    Inventors: Thomas Barton, Xin Gao, Jim Hunter, Paul R. LePlae, William C. Lo, Joshodeep Boruwa, Raghuram Tangirala, Gerald B. Watson, John Herbert
  • MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO
    Publication number: 20170208803
    Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing such molecules, and processes of using such molecules and compositions against such pests. These molecules and compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
    Type: Application
    Filed: January 18, 2017
    Publication date: July 27, 2017
    Applicant: Dow AgroSciences LLC
    Inventors: Thomas Barton, Xin Gao, Jim Hunter, Paul R. LePlae, JR., William C. Lo, Joshodeep Boruwa, Raghuram Tangirala, Gerald B. Watson, John Herbert
  • MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO
    Publication number: 20170208805
    Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing such molecules, and processes of using such molecules and compositions against such pests. These molecules and compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
    Type: Application
    Filed: January 18, 2017
    Publication date: July 27, 2017
    Applicant: Dow AgroSciences LLC
    Inventors: Thomas Barton, Xin Gao, Jim Hunter, Paul R. LePlae, JR., Lori K. Lawler, William C. Lo, Jeff Petkus, Joshodeep Boruwa, Raghuram Tangirala, Gerald B. Watson, John Herbert
  • MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO
    Publication number: 20170208804
    Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing such molecules, and processes of using such molecules and compositions against such pests. These molecules and compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
    Type: Application
    Filed: January 18, 2017
    Publication date: July 27, 2017
    Applicant: Dow AgroSciences LLC
    Inventors: Thomas Barton, Xin Gao, Jim Hunter, Paul R. LePlae, JR., William C. Lo, Joshodeep Boruwa, Raghuram Tangirala, Gerald B. Watson, John Herbert