Patents by Inventor Ragina Naidu

Ragina Naidu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cabazitaxel, related compounds and methods of synthesis
    Patent number: 9567312
    Abstract: The invention provides new cabazitaxel isoserine ester intermediates and new synthetic methods, and a preparation method for the anti-tumour drugs cabazitaxel, docetaxel and paclitaxel from the new cabazitaxel isoserine intermediates.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: February 14, 2017
    Inventors: Yunman Zheng, Tianhui Xu, Ragina Naidu
  • CABAZITAXEL, RELATED COMPOUNDS AND METHODS OF SYNTHESIS
    Publication number: 20140371474
    Abstract: The invention provides new cabazitaxel isoserine ester intermediates and new synthetic methods, and a preparation method for the anti-tumour drugs cabazitaxel, docetaxel and paclitaxel from the new cabazitaxel isoserine intermediates.
    Type: Application
    Filed: October 19, 2012
    Publication date: December 18, 2014
    Applicant: Shanghai Bioman Phama Limited
    Inventors: Yunman Zheng, Tianhui Xu, Ragina Naidu
  • Process to prepare camptothecin derivatives
    Patent number: 8592588
    Abstract: A process is provided for the preparation of camptothecin derivatives, such as irinotecan, in a one-pot operation.
    Type: Grant
    Filed: May 27, 2005
    Date of Patent: November 26, 2013
    Assignee: Chatham Biotec, Limited
    Inventor: Ragina Naidu
  • Semi-synthetic process for the preparation of taxane derivatives
    Patent number: 8299279
    Abstract: This invention relates to an improved semi-synthetic process for the preparation of taxane derivatives like paclitaxel, docetaxel, canadensol and its derivatives, the process, which has shorten reaction route, simple procedure, high yield and low materials cost, therefore facilitates the commercial manufacture of these derivatives.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: October 30, 2012
    Assignee: Chatham Biotec Ltd.
    Inventor: Ragina Naidu
  • One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
    Patent number: 8293930
    Abstract: A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediate in a one pot reaction of protecting the C-7 and C-10 positions and attaching a side chain at the C-13 position and subsequently deprotecting the group to form paclitaxel or docetaxel, and taxane intermediates.
    Type: Grant
    Filed: June 23, 2005
    Date of Patent: October 23, 2012
    Assignee: Chatham Biotec, Limited
    Inventor: Ragina Naidu
  • Semi-synthetic conversion of paclitaxel to docetaxel
    Patent number: 7906661
    Abstract: A process is provided for the semi-synthesis of taxane derivatives useful in the preparation of docetaxel, in particular, the semi-synthesis of protected taxane derivatives in a one pot reaction of protecting the C-2?, C-7 and C-10 positions and introducing a t-Boc group at the nitrogen of the amide group at the C-3? position in paclitaxel and subsequently conversion to docetaxel, and derivatives used therein.
    Type: Grant
    Filed: June 29, 2005
    Date of Patent: March 15, 2011
    Assignee: Chatham Biotec, Limited
    Inventors: Ragina Naidu, Samuel Siang Kiang Foo, BaoYu Xue, Bo Fan
  • Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
    Patent number: 7893283
    Abstract: A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediates.
    Type: Grant
    Filed: June 3, 2005
    Date of Patent: February 22, 2011
    Assignee: Chatham Biotec, Limited
    Inventor: Ragina Naidu
  • Semi-synthesis and isolation of taxane intermediates from a mixture of taxanes
    Patent number: 7838694
    Abstract: A process is provided for the semi-synthesis and isolation of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis and isolation of 10-deacetylbaccatin III, the semi-synthesis of a mixture of 10-deacetylbaccatin III and baccatin III, and protected derivatives thereof, from a mixture of taxanes.
    Type: Grant
    Filed: April 22, 2005
    Date of Patent: November 23, 2010
    Assignee: Chatham Biotec, Limited
    Inventors: Ragina Naidu, Samuel Siang Kiang Foo
  • Semi-Synthetic Process for the Preparation of Taxane Derivatives
    Publication number: 20100029957
    Abstract: This invention relates to an improved semi-synthetic process for the preparation of taxane derivatives like paclitaxel, docetaxel, canadensol and its derivatives, the process, which has shorten reaction route, simple procedure, high yield and low materials cost, therefore facilitates the commercial manufacture of these derivatives.
    Type: Application
    Filed: January 25, 2008
    Publication date: February 4, 2010
    Applicant: CHATHAM BRUNSWICK BIOTEC LTD
    Inventor: Ragina Naidu
  • Semi-synthesis of taxane intermediates and aziridine analogues and their conversion to paclitaxel and docetaxel
    Patent number: 7585986
    Abstract: A process is provided for the semi-synthesis of taxane intermediates and aziridine analogues of cephalomannine and baccatin III intermediates, and the conversion of such intermediates and analogues to paclitaxel and docetaxel.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: September 8, 2009
    Assignee: Chatham Biotec, Limited
    Inventor: Ragina Naidu
  • Process to Prepare Camptothecin Derivatives
    Publication number: 20080280935
    Abstract: A process is provided for the preparation of camptothecin derivatives, such as irinotecan, in a one-pot operation.
    Type: Application
    Filed: May 27, 2005
    Publication date: November 13, 2008
    Inventor: Ragina Naidu
  • Semi-Synthesis of Taxane Intermediates and Their Conversion to Paclitaxel and Docetaxel
    Publication number: 20080262250
    Abstract: A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediates.
    Type: Application
    Filed: June 3, 2005
    Publication date: October 23, 2008
    Inventor: Ragina Naidu
  • Semi-Synthesis and Isolation of Taxane Intermediates from a Mixture of Taxanes
    Publication number: 20080146824
    Abstract: A process is provided for the semi-synthesis and isolation of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis and isolation of 10-deacetylbaccatin III, the semi-synthesis of a mixture of 10-deacetylbaccatin III and baccatin III, and protected derivatives thereof, from a mixture of taxanes.
    Type: Application
    Filed: April 22, 2005
    Publication date: June 19, 2008
    Applicant: Chatham Biotec, Limited
    Inventors: Ragina Naidu, Samuel Siang Kiang Foo
  • Process to Prepare Camptothecin Derivatives and Novel Intermediate and Compounds Thereof
    Publication number: 20080051580
    Abstract: New processes are disclosed for the preparation of camptothecin derivatives, such as, irinotecan and topotecan, as well as new intermediates and compositions thereof.
    Type: Application
    Filed: June 3, 2005
    Publication date: February 28, 2008
    Inventor: Ragina Naidu
  • Semi-Synthetic Conversion of Paclitaxel to Docetaxel
    Publication number: 20080051590
    Abstract: A process is provided for the semi-synthesis of taxane derivatives useful in the preparation of docetaxel, in particular, the semi-synthesis of protected taxane derivatives in a one pot reaction of protecting the C-2?, C-7 and C-10 positions and introducing a t-Boc group at the nitrogen of the amide group at the C-3? position in paclitaxel and subsequently conversion to docetaxel, and derivatives used therein.
    Type: Application
    Filed: June 29, 2005
    Publication date: February 28, 2008
    Inventors: Ragina Naidu, Samuel Foo, Bao Xue, Bo Fan
  • Semi-Synthesis Of Taxane Intermediates And Aziridine Analogues And Their Conversion To Paclitaxel And Docetaxel
    Publication number: 20080033189
    Abstract: A process is provided for the semi-synthesis of taxane intermediates and aziridine analogues of cephalomannine and baccatin III intermediates, and the conversion of such intermediates and analogues to paclitaxel and docetaxel.
    Type: Application
    Filed: February 24, 2005
    Publication date: February 7, 2008
    Inventor: Ragina Naidu
  • Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
    Patent number: 7202370
    Abstract: A method is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel from 9-dihydro-13-acetylbaccatin III. The preparation of a suitably protected baccatin III backbone from 9-dihydro-13-acetylbaccatin III, and the insertion of the phenylisoserine side chain onto the protected baccatin III from 9-dihydro-13-acetylbaccatin III to form the taxane derivatives, paclitaxel and docetaxel is disclosed.
    Type: Grant
    Filed: October 27, 2003
    Date of Patent: April 10, 2007
    Assignee: Conor Medsystems, Inc.
    Inventor: Ragina Naidu
  • Semi-synthesis and isolation of taxane intermediates from a mixture of taxanes
    Publication number: 20070073069
    Abstract: A process is provided for the semi-synthesis and isolation of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis and isolation of 10-deacetylbaccatin III, and protected derivatives thereof, from a mixture of taxanes.
    Type: Application
    Filed: July 7, 2006
    Publication date: March 29, 2007
    Inventors: Ragina Naidu, Samuel Foo
  • Novel taxanes and methods related to use and preparation thereof
    Publication number: 20070032646
    Abstract: Disclosed are taxanes having utility as intermediates in the preparation of paclitaxel, taxotere and analogs thereof, and methods related to the preparation of the same.
    Type: Application
    Filed: March 23, 2006
    Publication date: February 8, 2007
    Inventor: Ragina Naidu
  • Semi-synthesis of taxane intermediates from a mixture of taxanes
    Publication number: 20070032668
    Abstract: A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of 10-deacetylbaccatin III and baccatin III, and derivatives thereof, from a mixture of taxanes.
    Type: Application
    Filed: June 12, 2006
    Publication date: February 8, 2007
    Inventors: Ragina Naidu, Samuel Foo