Patents by Inventor Ragnhild Lothe
Ragnhild Lothe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11555222Abstract: The present invention provides a method of quantification of a target nucleic acid, using at least any two of the genes SYT10, EPHA3, PLEKHF1 and KBTBD4 as control genes. In particular, the combination of the genes SYT10, EPHA3, PLEKHF1 and KBTBD4, known as the 4Plex, is provided as a control for nucleic acid quantification. The 4Plex has particular utility as a control for nucleic acid quantification by methylation-specific droplet digital PCR.Type: GrantFiled: November 30, 2018Date of Patent: January 17, 2023Assignee: OSLO UNIVERSITETSSYKEHUS HFInventors: Guro E. Lind, Marine Jeanmougin, Heidi D. Pharo, Kim Andresen, Ragnhild Lothe
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Publication number: 20220017966Abstract: Provided herein are compositions and methods for characterizing bladder cancer. In particular, provided herein are methylation markers for bladder cancer and bladder cancer recurrence.Type: ApplicationFiled: November 15, 2019Publication date: January 20, 2022Inventors: Guro E. Lind, Rolf Wahlqvist, Ragnhild A. Lothe, Carmen Jeronimo, Heidi D. Pharo
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Patent number: 10598663Abstract: The present invention relates to methods and biomarkers (e.g., protein biomarkers) for detection of colorectal cancer in biological samples (e.g., tissue samples, biopsy samples, stool samples, blood samples, plasma samples, serum samples). In some embodiments, methods and biomarkers of the present invention find use in detection of colon cancer, providing a prognosis to colorectal cancer patients, and in companion diagnostics.Type: GrantFiled: April 10, 2015Date of Patent: March 24, 2020Assignee: Oslo Universitetssykehus HFInventors: Ragnhild A. Lothe, Jarle Bruun, Matthias Kolberg, Rolf Inge Skotheim, Guro Elisabeth Lind, Arild Nesbakken
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Publication number: 20190221286Abstract: A method of estimating thresholds for droplet digital polymerase chain reaction (ddPCR) experiments is described. The method comprises receiving amplitude values for multiple ddPCR experiments and, for each experiment, determining if the distribution of amplitude values is multimodal or unimodal. In the case of unimodality where the amplitude values have a single component then a threshold for the experiment is defined as the maximum amplitude value. In the case of multimodality where the amplitude values hence include multiple components then a threshold for the experiment is defined as the mean between the medians of the first two components. The method thereby obtains individual thresholds for each of the multiple ddPCR experiments.Type: ApplicationFiled: January 11, 2019Publication date: July 18, 2019Inventors: Guro E. Lind, Marine Jeanmougin, Heidi D. Pharo, Kim Andresen, Ragnhild Lothe
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Patent number: 10308980Abstract: The present invention relates to methods and biomarkers (e.g., gene expression biomarkers) for detection of colorectal cancer in biological samples (e.g., tissue samples, biopsy samples, stool samples, blood samples, plasma samples, serum samples). In some embodiments, methods and biomarkers of the present invention find use in detection of colon cancer and in providing a prognosis to colorectal cancer patients.Type: GrantFiled: November 5, 2012Date of Patent: June 4, 2019Assignee: OSLO UNIVERSITETSSYKEHUS HFInventors: Ragnhild A. Lothe, Trude Holmeide Agesen, Anita Sveen, Guro Elisabeth Lind, Arild Nesbakken, Rolf Inge Skotheim
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Publication number: 20180023147Abstract: The invention relates to methods and biomarkers (e.g., epigenetic biomarkers) for detection of bladder cancer in biological samples (e.g., tissue samples, urine samples, urine sediments). In some embodiments, methods and biomarkers of the present invention find use in discriminating between bladder cancer, prostate cancer and renal epithelial tumors.Type: ApplicationFiled: October 9, 2017Publication date: January 25, 2018Inventors: Guro Elisabeth Lind, Ragnhild A. Lothe, Rolf Inge Skotheim, Carmen Jeronimo, Vera L. Costa, Rui Henrique, Manuel R. Teixeira
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Patent number: 9822417Abstract: The present invention relates to methods and biomarkers (e.g., gene expression biomarkers) for detection of colorectal cancer in biological samples (e.g., tissue samples, biopsy samples, stool samples, blood samples, plasma samples, serum samples). In some embodiments, methods and biomarkers of the present invention find use in detection of colon cancer, providing a prognosis to colorectal cancer patients, and in companion diagnostics.Type: GrantFiled: January 9, 2013Date of Patent: November 21, 2017Assignee: OSLO UNIVERSITETSSYKEHUS HFInventors: Ragnhild A. Lothe, Anita Sveen, Trude Holmeide Agesen, Guro Elisabeth Lind, Arild Nesbakken, Rolf Inge Skotheim
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Patent number: 9797016Abstract: The invention relates to methods and biomarkers (e.g., epigenetic biomarkers) for detection of bladder cancer in biological samples (e.g., tissue samples, urine samples, urine sediments). In some embodiments, methods and biomarkers of the present invention find use in discriminating between bladder cancer, prostate cancer and renal epithelial tumors.Type: GrantFiled: October 19, 2011Date of Patent: October 24, 2017Assignee: OSLO UNIVERSITETSSYKEHUS HFInventors: Guro Elisabeth Lind, Ragnhild A. Lothe, Rolf Inge Skotheim, Carmen Jeronimo, Vera L. Costa, Rui Henrique, Manuel R. Teixeira
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Publication number: 20170038386Abstract: The present invention relates to methods and biomarkers (e.g., protein biomarkers) for detection of colorectal cancer in biological samples (e.g., tissue samples, biopsy samples, stool samples, blood samples, plasma samples, serum samples). In some embodiments, methods and biomarkers of the present invention find use in detection of colon cancer, providing a prognosis to colorectal cancer patients, and in companion diagnostics.Type: ApplicationFiled: April 10, 2015Publication date: February 9, 2017Inventors: Ragnhild A. Lothe, Jarle Bruun, Matthias Kolberg, Rolf Inge Skotheim, Guro Elisabeth Lind, Arild Nesbakken
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Publication number: 20150176079Abstract: The present invention relates to novel markers for hypermethylation of gene promoters in cancers. In particular the present invention relates to a method of determining whether a tumour is developing in the aero-digestive system, or whether a subject is relapsing after treatment of such a tumour. The method comprises determining the methylation level, the number of methylated CpG sites or the methylation state of CpG sites in a nucleic acid sequence in the promoter region, first exon or intron, of one or more genes selected from the group consisting of CNRIP1, MAL, FBN1, SPG20, SNCA, and INA. The method further relates to a diagnostic kit for detecting tumours in the aero-digestive tract.Type: ApplicationFiled: December 10, 2014Publication date: June 25, 2015Inventors: Rolf I. Skotheim, Ragnhild A. Lothe, Guro E. Lind, Terje C. Ahlquist
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Publication number: 20140342361Abstract: The present invention relates to methods and biomarkers (e.g., gene expression biomarkers) for detection of colorectal cancer in biological samples (e.g., tissue samples, biopsy samples, stool samples, blood samples, plasma samples, serum samples). In some embodiments, methods and biomarkers of the present invention find use in detection of colon cancer, providing a prognosis to colorectal cancer patients, and in companion diagnostics.Type: ApplicationFiled: January 9, 2013Publication date: November 20, 2014Inventors: Ragnhild A. Lothe, Anita Sveen, Trude Holmeide Agesen, Guro Elisabeth Lind, Arild Nesbakken, Rolf Inge Skotheim
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Publication number: 20140302100Abstract: The present invention relates to methods and biomarkers (e.g., gene expression biomarkers) for detection of colorectal cancer in biological samples (e.g., tissue samples, biopsy samples, stool samples, blood samples, plasma samples, serum samples). In some embodiments, methods and biomarkers of the present invention find use in detection of colon cancer and in providing a prognosis to colorectal cancer patients.Type: ApplicationFiled: November 5, 2012Publication date: October 9, 2014Inventors: Ragnhild A. Lothe, Trude Holmeide Agesen, Anita Sveen, Guro Elisabeth Lind, Arild Nesbakken, Rolf Inge Skotheim
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Publication number: 20140031257Abstract: The present invention relates to methods and biomarkers (e.g., epigenetic biomarkers) for detection of gastrointestinal cancers (e.g., colorectal cancer, gastric cancer, pancreatic cancer, liver cancer, cancer of the gall bladder and/or bile ducts (e.g., cholangiocarcinoma)) in biological samples (e.g., tissue samples, stool samples, blood samples, plasma samples, cell samples, gall samples, bile samples, serum samples).Type: ApplicationFiled: March 8, 2012Publication date: January 30, 2014Applicant: OSLO UNIVERSITETSSYKEHUS HFInventors: Ragnhild A. Lothe, Guro E. Lind, Deeqa Ahmed, Kim Andresen, Rolf I. Skotheim
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Publication number: 20130210011Abstract: The invention relates to methods and biomarkers (e.g., epigenetic biomarkers) for detection of bladder cancer in biological samples (e.g., tissue samples, urine samples, urine sediments). In some embodiments, methods and biomarkers of the present invention find use in discriminating between bladder cancer, prostate cancer and renal epithelial tumors.Type: ApplicationFiled: October 19, 2011Publication date: August 15, 2013Applicant: OSLO UNIVERSITETSSYKEHUS HFInventors: Guro Elisabeth Lind, Ragnhild A. Lothe, Rolf Inge Skotheim, Carmen Jeronimo, Vera L. Costa, Rui Henrique, Manuel R. Teixeira
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Publication number: 20120172242Abstract: The present inventors here present a novel strategy for identification of RNA transcript variants and demonstrate that these can be correlated to disease states in mammals such as cancer. In particular, the transcript variants show prevalence and specificity to cancer, and thus also show clinical applicability in e.g. cancer diagnostics and prognostics, treatment and therapeutics. The present inventors have identified RNA transcript variants of VNN1 that can be used as biomarkers. The RNA transcript variant may also be used as biomarkers for diagnosing, prognosing, and/or monitoring a cancer.Type: ApplicationFiled: December 17, 2009Publication date: July 5, 2012Applicant: OSLO UNIVERSITETSSYKEHUS HFInventors: Rolf I. Skotheim, Guro E. Lind, Ragnhild A. Lothe, Marthe Eken, Gard O.S. Thomassen
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Publication number: 20100279890Abstract: The present invention relates to a microarray comprising a chimeric probe for an intergenic exon-to-exon junction of a fusion gene and at least two intragenic probes for a fusion gene partner of the fusion gene. The invention further relates to a method of detecting a fusion gene and a kit suitable for detecting fusion genes.Type: ApplicationFiled: June 27, 2008Publication date: November 4, 2010Applicant: OSLO UNIVERSITETSSYKEHUS HFInventors: Ragnhild A. Lothe, Guro E. Lind, Rolf I. Skotheim, Gard O.S. Thomassen, Torbjørn Rognes
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Publication number: 20100062440Abstract: The present invention relates to novel markers for hypermethylation of gene promoters in cancers. In particular the present invention relates to a method of determining whether a tumour is developing in the aero-digestive system, or whether a subject is relapsing after treatment of such a tumour. The method comprises determining the methylation level, the number of methylated CpG sites or the methylation state of CpG sites in a nucleic acid sequence in the promoter region, first exon or intron, of one or more genes selected from the group consisting of CNRIP1, MAL, FBN1, SPG20, SNCA, and INA. The method further relates to a diagnostic kit for detecting tumours in the aero-digestive tract.Type: ApplicationFiled: February 21, 2008Publication date: March 11, 2010Applicant: OSLO UNIVERSITETSSYKEHUS HFInventors: Rolf I. Skotheim, Ragnhild A. Lothe, Guro E. Lind, Terje C. Ahlquist